A16L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: A16L2_HUMAN
• UniProt AC: Q8NAA4
• Protein Name: Autophagy-related protein 16-2
• Gene Name: ATG16L2
• Organism: Homo sapiens (Human).
• Sequence Length: 619
• Subcellular Localization: Cytoplasm. Localizes also to discrete punctae along the ciliary axoneme..
• Protein Description: May play a role in autophagy..
• Protein Sequence: MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	EKGAALGTLESELQQ HHCHHHCCHHHHHHH	28.36	27174698
123	Phosphorylation	AALGTLESELQQRQS HHHCCHHHHHHHHHH	46.87	27174698
130	Phosphorylation	SELQQRQSRLAALEA HHHHHHHHHHHHHHH	31.30	27174698
232	Phosphorylation	LKKAAKRTVSISEGP HHHHHHCCCCCCCCC	20.21	28450419
234	Phosphorylation	KAAKRTVSISEGPDT HHHHCCCCCCCCCCC	21.56	28450419
236	Phosphorylation	AKRTVSISEGPDTLG HHCCCCCCCCCCCCC	29.06	28450419
241	Phosphorylation	SISEGPDTLGDGMRE CCCCCCCCCCCCHHH	35.46	-
276	Phosphorylation	KWKRPFRSASATSLT HCCCCCCCCCCHHHC	27.27	28450419
278	Phosphorylation	KRPFRSASATSLTLS CCCCCCCCCHHHCHH	33.07	28450419
280	Phosphorylation	PFRSASATSLTLSHC CCCCCCCHHHCHHHH	23.05	26657352
281	Phosphorylation	FRSASATSLTLSHCV CCCCCCHHHCHHHHH	21.05	29978859
283	Phosphorylation	SASATSLTLSHCVDV CCCCHHHCHHHHHHH	26.44	26552605
285	Phosphorylation	SATSLTLSHCVDVVK CCHHHCHHHHHHHHH	15.03	26552605
304	Phosphorylation	FKKRRGHSIGGAPEQ HHHHCCCCCCCCHHH	26.25	25849741
419	Phosphorylation	AQSKETLSGHKDKVT CCCCCCCCCCCCCHH	46.39	29396449
441	Phosphorylation	RHQAVTGSRDRTVKE EHHHCCCCCCCCHHH	22.95	-
445	Phosphorylation	VTGSRDRTVKEWDLG CCCCCCCCHHHHHCC	39.97	24702127
552	Phosphorylation	FKCGSDWTKAVFSPD CCCCCCCHHEECCCC	17.70	-
557	Phosphorylation	DWTKAVFSPDRSYAL CCHHEECCCCCHHCC	21.20	-
608	Phosphorylation	YSGSHMVSVDQGRKV HHCCCEEEEECCCCE	16.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of A16L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of A16L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of A16L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKKA_HUMAN	CHUK	physical	23563314

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.