COBA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COBA2_HUMAN
• UniProt AC: P13942
• Protein Name: Collagen alpha-2(XI) chain
• Gene Name: COL11A2
• Organism: Homo sapiens (Human).
• Sequence Length: 1736
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils..
• Protein Sequence: MERCSRCHRLLLLLPLVLGLSAAPGWAGAPPVDVLRALRFPSLPDGVRRAKGICPADVAYRVARPAQLSAPTRQLFPGGFPKDFSLLTVVRTRPGLQAPLLTLYSAQGVRQLGLELGRPVRFLYEDQTGRPQPPSQPVFRGLSLADGKWHRVAVAVKGQSVTLIVDCKKRVTRPLPRSARPVLDTHGVIIFGARILDEEVFEGDVQELAIVPGVQAAYESCEQKELECEGGQRERPQNQQPHRAQRSPQQQPSRLHRPQNQEPQSQPTESLYYDYEPPYYDVMTTGTTPDYQDPTPGEEEEILESSLLPPLEEEQTDLQVPPTADRFQAEEYGEGGTDPPEGPYDYTYGYGDDYREETELGPALSAETAHSGAAAHGPRGLKGEKGEPAVLEPGMLVEGPPGPEGPAGLIGPPGIQGNPGPVGDPGERGPPGRAGLPGSDGAPGPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAILQQARLALRGPPGPMGYTGRPGPLGQPGSPGLKGESGDLGPQGPRGPQGLTGPPGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGAIGPHGEKGPQGKPGLPGMPGSDGPPGHPGKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPLGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGEKGESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPGLRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSLREEIEQMRRPTGTQDSPARTCQDLKLCHPELPDGEYWVDPNQGCARDAFRVFCNFTAGGETCVTPRDDVTQFSYVDSEGSPVGVVQLTFLRLLSVSAHQDVSYPCSGAARDGPLRLRGANEDELSPETSPYVKEFRDGCQTQQGRTVLEVRTPVLEQLPVLDASFSDLGAPPRRGGVLLGPVCFMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LRALRFPSLPDGVRR HHHHCCCCCCCHHHH	50.23	22985185
60	Phosphorylation	ICPADVAYRVARPAQ CCHHHHHHHHCCHHH	12.88	22817900
172	Phosphorylation	VDCKKRVTRPLPRSA EECCCCCCCCCCCCC	30.51	22985185
288 (in isoform 9)	Phosphorylation	-	18.59	24719451
288	Phosphorylation	DVMTTGTTPDYQDPT CCCCCCCCCCCCCCC	18.59	24719451
439	Phosphorylation	GRAGLPGSDGAPGPP CCCCCCCCCCCCCCC	30.82	24114839
506	Phosphorylation	GPLGQPGSPGLKGES CCCCCCCCCCCCCCC	23.60	24719451
555	Methylation	MPGDPGVKGDRGFDG CCCCCCCCCCCCCCC	62.09	-
576	Phosphorylation	EKGHRGDTGAQGLPG CCCCCCCCCCCCCCC	36.92	-
686	Phosphorylation	GLPGMPGSDGPPGHP CCCCCCCCCCCCCCC	33.26	-
701	Phosphorylation	GKEGPPGTKGNQGPS CCCCCCCCCCCCCCC	41.37	-
732	Acetylation	VDGIRGLKGHKGEKG CCCCCCCCCCCCCCC	62.89	25953088
777	Phosphorylation	PEGPKGRTGPTGDPG CCCCCCCCCCCCCCC	57.07	22817900
843	Phosphorylation	PRGERGPTGPRGQRG CCCCCCCCCCCCCCC	63.74	-
1325	Phosphorylation	GKRGPAGSPGSEGRQ CCCCCCCCCCCCCCC	28.35	24732914
1328	Phosphorylation	GPAGSPGSEGRQGGK CCCCCCCCCCCCCCC	40.02	24732914
1338	Acetylation	RQGGKGAKGDPGAIG CCCCCCCCCCCCCCC	72.94	12433391
1439	Phosphorylation	GLPGPQGSPGQKGEM CCCCCCCCCCCCCCC	22.17	-
1519	Phosphorylation	TRRSVDGSRLMQEDE CCCCCCHHHHCCCCC	20.13	-
1530	Phosphorylation	QEDEAIPTGGAPGSP CCCCCCCCCCCCCCC	41.98	22210691
1536	Phosphorylation	PTGGAPGSPGGLEEI CCCCCCCCCCHHHHH	21.22	22210691
1549	Phosphorylation	EIFGSLDSLREEIEQ HHHCCHHHHHHHHHH	34.32	22210691
1604	N-linked_Glycosylation	DAFRVFCNFTAGGET HHHHHEEECCCCCCC	26.32	UniProtKB CARBOHYD
1675	Phosphorylation	GANEDELSPETSPYV CCCCCCCCCCCCHHH	20.74	-
1678	Phosphorylation	EDELSPETSPYVKEF CCCCCCCCCHHHHHH	38.08	-
1679	Phosphorylation	DELSPETSPYVKEFR CCCCCCCCHHHHHHH	16.75	-
1681	Phosphorylation	LSPETSPYVKEFRDG CCCCCCHHHHHHHCC	24.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COBA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COBA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COBA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of COBA2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 184840: Stickler syndrome 3 (STL3)
• 215150: Otospondylomegaepiphyseal dysplasia (OSMED)
• 277610: Weissenbacher-Zweymueller syndrome (WZS)
• 601868: Deafness, autosomal dominant, 13 (DFNA13)
• 609706: Deafness, autosomal recessive, 53 (DFNB53)
• 614524: Fibrochondrogenesis 2 (FBCG2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.