MPPD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPPD1_HUMAN
• UniProt AC: O15442
• Protein Name: Metallophosphoesterase domain-containing protein 1
• Gene Name: MPPED1
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Protein Description: May have metallophosphoesterase activity (in vitro)..
• Protein Sequence: MWRSRWDASVLKAEALALLPCGLGMAFSQSHVMAARRHQHSRLIIEVDEYSSNPTQAFTFYNINQGRFQPPHVQMVDPVPHDAPKPPGYTRFVCVSDTHSRTDPIQMPYGDVLIHAGDFTELGLPSEVKKFNEWLGSLPYEYKIVIAGNHELTFDQEFMADLIKQDFYYFPSVSKLKPENYENVQSLLTNCIYLQDSEVTVRGFRIYGSPWQPWFYGWGFNLPRGQALLEKWNLIPEGVDILITHGPPLGFLDWVPKKMQRVGCVELLNTVQRRVQPRLHVFGHIHEGYGVMADGTTTYVNASVCTVNYQPVNPPIVIDLPTPRNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Phosphorylation	VSDTHSRTDPIQMPY EECCCCCCCCCCCCC	49.49	25072903
109	Phosphorylation	TDPIQMPYGDVLIHA CCCCCCCCCCEEEEC	22.18	25072903
120	Phosphorylation	LIHAGDFTELGLPSE EEECCCCCCCCCCHH	34.73	25072903
126	Phosphorylation	FTELGLPSEVKKFNE CCCCCCCHHHHHHHH	61.13	25072903
172	Phosphorylation	QDFYYFPSVSKLKPE CCCCCCCCHHHCCCC	29.17	26091039
174	Phosphorylation	FYYFPSVSKLKPENY CCCCCCHHHCCCCCH	36.29	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPPD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPPD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPPD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CIAO1_HUMAN	CIAO1	physical	26186194
TCPH_HUMAN	CCT7	physical	26186194
KPB1_HUMAN	PHKA1	physical	26186194
KPB2_HUMAN	PHKA2	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
MMS19_HUMAN	MMS19	physical	26186194
NR2F6_HUMAN	NR2F6	physical	26186194
COT1_HUMAN	NR2F1	physical	26186194
COT2_HUMAN	NR2F2	physical	26186194
CLU_HUMAN	CLUH	physical	26186194
KPBB_HUMAN	PHKB	physical	26186194
UCKL1_HUMAN	UCKL1	physical	26186194
NARF_HUMAN	NARF	physical	26186194
TXND9_HUMAN	TXNDC9	physical	26186194
MPPD2_HUMAN	MPPED2	physical	26186194
UCK1_HUMAN	UCK1	physical	26186194
DNPEP_HUMAN	DNPEP	physical	26186194
PHKG2_HUMAN	PHKG2	physical	26186194
UBP33_HUMAN	USP33	physical	26186194
UPP_HUMAN	UPRT	physical	26186194
ZN232_HUMAN	ZNF232	physical	26186194
KPBB_HUMAN	PHKB	physical	28514442
KPB2_HUMAN	PHKA2	physical	28514442
PHKG2_HUMAN	PHKG2	physical	28514442
KPB1_HUMAN	PHKA1	physical	28514442
NR2F6_HUMAN	NR2F6	physical	28514442
NARF_HUMAN	NARF	physical	28514442
UPP_HUMAN	UPRT	physical	28514442
CLU_HUMAN	CLUH	physical	28514442
UCK1_HUMAN	UCK1	physical	28514442
UCKL1_HUMAN	UCKL1	physical	28514442
DNPEP_HUMAN	DNPEP	physical	28514442
ZN232_HUMAN	ZNF232	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
TXND9_HUMAN	TXNDC9	physical	28514442
COT1_HUMAN	NR2F1	physical	28514442
CIAO1_HUMAN	CIAO1	physical	28514442
MMS19_HUMAN	MMS19	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.