UPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UPP_HUMAN
• UniProt AC: Q96BW1
• Protein Name: Uracil phosphoribosyltransferase homolog
• Gene Name: UPRT
• Organism: Homo sapiens (Human).
• Sequence Length: 309
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Sequence: MATELQCPDSMPCHNQQVNSASTPSPEQLRPGDLILDHAGGNRASRAKVILLTGYAHSSLPAELDSGACGGSSLNSEGNSGSGDSSSYDAPAGNSFLEDCELSRQIGAQLKLLPMNDQIRELQTIIRDKTASRGDFMFSADRLIRLVVEEGLNQLPYKECMVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKFPPDIYRRKVLLMYPILSTGNTVIEAVKVLIEHGVQPSVIILLSLFSTPHGAKSIIQEFPEITILTTEVHPVAPTHFGQKYFGTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	VNSASTPSPEQLRPG CCCCCCCCHHHCCCC	40.95	28348404
87	Phosphorylation	SGSGDSSSYDAPAGN CCCCCCCCCCCCCCC	30.86	-
124	Phosphorylation	DQIRELQTIIRDKTA HHHHHHHHHHHCCCC	30.88	-
130	Phosphorylation	QTIIRDKTASRGDFM HHHHHCCCCCCCCCC	33.87	-
137	Sulfoxidation	TASRGDFMFSADRLI CCCCCCCCCCHHHHH	2.85	21406390
177	Ubiquitination	YEGVKFEKGNCGVSI EECEEECCCCEEEEE	59.56	-
206	Ubiquitination	CRSIRIGKILIQSDE HHHCCEEEEEECCCH	31.78	-
238	Phosphorylation	RRKVLLMYPILSTGN HCHHHHHEEECCCCC	6.26	29978859
242	Phosphorylation	LLMYPILSTGNTVIE HHHEEECCCCCHHHH	34.68	29978859
243	Phosphorylation	LMYPILSTGNTVIEA HHEEECCCCCHHHHH	30.88	29978859
246	Phosphorylation	PILSTGNTVIEAVKV EECCCCCHHHHHHHH	24.97	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UPP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UPP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UCK1_HUMAN	UCK1	physical	26186194
UCK2_HUMAN	UCK2	physical	26186194
I2BP2_HUMAN	IRF2BP2	physical	26186194
UCKL1_HUMAN	UCKL1	physical	26186194
PYRD1_HUMAN	PYROXD1	physical	21516116
UCK2_HUMAN	UCK2	physical	28514442
UCKL1_HUMAN	UCKL1	physical	28514442
UCK1_HUMAN	UCK1	physical	28514442
I2BP2_HUMAN	IRF2BP2	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.