HMGX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGX3_HUMAN
• UniProt AC: Q12766
• Protein Name: HMG domain-containing protein 3
• Gene Name: HMGXB3
• Organism: Homo sapiens (Human).
• Sequence Length: 1538
• Subcellular Localization: Nucleus .
• Protein Sequence: MQRTQPRPCYLNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLDPLQAFEQFVWVRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRSVVCRYCRCSRQTGASVTTVSLPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAGPRGRGSFSPRDARASPRLHFLVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRSLHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPNSKLSALTAVVPDIPGFRKILPRSDYIIIPKSSLQEDRSCPQLELCVAQNQMSPKGPPLVSNTAPETVPSHAGMAEQCLAVEALAEEVGALTQSGAVQEIATSEILSQDVLLEDASLEVGESHQPYQTSLVIEETLVNGSPDLPTGSLAVPHPQVGESVSVVTVMRDSSESSSSAPATQFIMLPLPAYSVVENPTSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKPPKCPTCGNFLGGKWIPKEKPAKVKVELASGVSSKGSVVKRNQQPVTTEQNSSKENASKLTLENSEAVSQLLNVAPPREVGEESEWEEVIISDAHVLVKEAPGNCGTAVTKTPVVKSGVQPEVTLGTTDNDSPGADVPTPSEGTSTSSPLPAPKKPTGADLLTPGSRAPELKGRARGKPSLLAAARPMRAILPAPVNVGRGSSMGLPRARQAFSLSDKTPSVRTCGLKPSTLKQLGQPIQQPSGPGEVKLPSGPSNRTSQVKVVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQSTLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRLQTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEELSQLQELLCNGYWAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQLCFSLLALYESVQNGARAIRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVSVSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATILASIVDSKPNGVRQRPIAFDNATHYYLYNRLMDFLTSREIVNRQIHDIVQSCQPGEVVIRDTLYRLGVAQIKTETEEEGEEEEVAAVAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MQRTQPRPCYL ----CCCCCCCCCCC	42.50	29759185
32	Phosphorylation	RPTAGSHSFLLRPGP CCCCCCCCEEECCCC	21.20	24719451
112	Phosphorylation	YCRCSRQTGASVTTV HHHCCCCCCCCEEEE	33.34	30576142
115	Phosphorylation	CSRQTGASVTTVSLP CCCCCCCCEEEEECC	22.72	30576142
157	Phosphorylation	LFLPFRTPYRDSEEG EEEECCCCCCCCHHH	20.22	27251275
195	Phosphorylation	SPRDARASPRLHFLV CHHHCCCCCCCCHHH	12.66	22210691
287	Acetylation	KYKIHGEKTKKPRSA CCCCCCCCCCCCCCE	70.95	7708253
345	Ubiquitination	LEKAKLEKEGLDPNS HHHHHHHHCCCCCCC	68.47	-
352	Phosphorylation	KEGLDPNSKLSALTA HCCCCCCCHHHHHHH	40.12	-
353	Ubiquitination	EGLDPNSKLSALTAV CCCCCCCHHHHHHHC	53.77	21906983
376	Phosphorylation	KILPRSDYIIIPKSS HHCCCCCEEEEECHH	8.68	27642862
403	Phosphorylation	CVAQNQMSPKGPPLV HHHCCCCCCCCCCCC	17.44	28985074
563	Phosphorylation	RGHGTCTSPGCSFTY CCCCEECCCCCCEEE	22.80	28555341
600	Sumoylation	KEKPAKVKVELASGV CCCCCCEEEEECCCC	29.32	-
605	Phosphorylation	KVKVELASGVSSKGS CEEEEECCCCCCCCC	52.96	-
609	Phosphorylation	ELASGVSSKGSVVKR EECCCCCCCCCEEEC	38.33	23532336
612	Phosphorylation	SGVSSKGSVVKRNQQ CCCCCCCCEEECCCC	27.72	23532336
629	Ubiquitination	TTEQNSSKENASKLT CCCCCCCHHHHHHHE	55.60	-
665	Phosphorylation	ESEWEEVIISDAHVL CCCCEEEEEECCEEE	2.56	27251275
702	Phosphorylation	QPEVTLGTTDNDSPG CCEEEECCCCCCCCC	33.80	25627689
703	Phosphorylation	PEVTLGTTDNDSPGA CEEEECCCCCCCCCC	30.89	25627689
722	Phosphorylation	PSEGTSTSSPLPAPK CCCCCCCCCCCCCCC	29.71	25627689
755	Phosphorylation	GRARGKPSLLAAARP CCCCCCHHHHHHHCC	39.23	18187866
775	Methylation	PAPVNVGRGSSMGLP CCCCCCCCCCCCCCH	37.22	80702595
783	Methylation	GSSMGLPRARQAFSL CCCCCCHHHHHHHCC	47.66	115386277
789	Phosphorylation	PRARQAFSLSDKTPS HHHHHHHCCCCCCCC	29.94	-
791	Phosphorylation	ARQAFSLSDKTPSVR HHHHHCCCCCCCCHH	35.54	-
794	Phosphorylation	AFSLSDKTPSVRTCG HHCCCCCCCCHHCCC	26.28	-
905	Ubiquitination	DRTEKTTKAIEVSSP CCCCCCCEEEEECCC	53.23	-
910	Phosphorylation	TTKAIEVSSPLPDVL CCEEEEECCCCCCCC	17.28	30624053
911	Phosphorylation	TKAIEVSSPLPDVLN CEEEEECCCCCCCCC	35.31	30624053
1028	Phosphorylation	ASRLQTVTAQVKMCL HHHHHHHHHHHHHHC	18.11	-
1082	Phosphorylation	LGEDPRVSINVVLKS CCCCCCEEEEEEEHH	15.10	28102081
1318	Phosphorylation	PHQVVCGSKYLVRGE CCCEEECCEEEECCC	17.01	29083192
1320	Phosphorylation	QVVCGSKYLVRGESA CEEECCEEEECCCCH	16.48	29083192
1500	Phosphorylation	QIHDIVQSCQPGEVV HHHHHHHHCCCCCEE	12.11	26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGX3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMGX3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HMGX3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.