KBRS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBRS2_HUMAN
• UniProt AC: Q9NYR9
• Protein Name: NF-kappa-B inhibitor-interacting Ras-like protein 2
• Gene Name: NKIRAS2
• Organism: Homo sapiens (Human).
• Sequence Length: 191
• Subcellular Localization: Cytoplasm.
• Protein Description: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)..
• Protein Sequence: MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFYDTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGNKCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPLSRKNKGSGSLDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	QASVGKTSILEQLLY CCCCCCHHHHHHHHH	28.76	25954137
33	Phosphorylation	YGNHVVGSEMIETQE HCCCCCCCCEEECCC	16.63	25954137
43	Phosphorylation	IETQEDIYVGSIETD EECCCCEEEEEEECC	15.87	25954137
66 (in isoform 4)	Phosphorylation	-	43.04	25159151
68 (in isoform 4)	Phosphorylation	-	17.95	25159151
77 (in isoform 4)	Phosphorylation	-	22.85	-
118	Ubiquitination	KEVTIVVLGNKCDLQ CEEEEEEECCCCCHH	4.30	21890473
121	Ubiquitination	TIVVLGNKCDLQEQR EEEEECCCCCHHHHH	27.59	-
140	Acetylation	DVAQHWAKSEKVKLW HHHHHHHHCCCCEEE	54.69	25953088
140	Ubiquitination	DVAQHWAKSEKVKLW HHHHHHHHCCCCEEE	54.69	-
150	Phosphorylation	KVKLWEVSVADRRSL CCEEEEEEHHHHHHH	10.48	28857561
156	Phosphorylation	VSVADRRSLLEPFVY EEHHHHHHHHHHHHH	37.89	28857561
167	Ubiquitination	PFVYLASKMTQPQSK HHHHHHHHCCCCCCC	40.12	-
172 (in isoform 2)	Ubiquitination	-	54.39	21890473
174	Ubiquitination	KMTQPQSKSAFPLSR HCCCCCCCCCCCCCC	40.32	2189047
174 (in isoform 1)	Ubiquitination	-	40.32	21890473
180	Phosphorylation	SKSAFPLSRKNKGSG CCCCCCCCCCCCCCC	41.25	27535140
186	Phosphorylation	LSRKNKGSGSLDG-- CCCCCCCCCCCCC--	27.15	19581576
188	Phosphorylation	RKNKGSGSLDG---- CCCCCCCCCCC----	25.61	19581576

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBRS2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBRS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBRS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX6_HUMAN	PAX6	physical	21988832
GFOD1_HUMAN	GFOD1	physical	28514442
RGPA2_HUMAN	RALGAPA2	physical	28514442
RGPA1_HUMAN	RALGAPA1	physical	28514442
RLGPB_HUMAN	RALGAPB	physical	28514442
GFOD2_HUMAN	GFOD2	physical	28514442
GDS1_HUMAN	RAP1GDS1	physical	28514442
DCA10_HUMAN	DCAF10	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.