dbPTM

RGPA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RGPA2_HUMAN
UniProt AC	Q2PPJ7
Protein Name	Ral GTPase-activating protein subunit alpha-2
Gene Name	RALGAPA2
Organism	Homo sapiens (Human).
Sequence Length	1873
Subcellular Localization	Cytoplasm .
Protein Description	Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB..
Protein Sequence	MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYENFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTGNSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPSVADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKFLFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAARVVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKSHSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEIAVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSSWGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVDACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFRTLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEMTNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAPGVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQGQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRERQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASNLTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYELWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLICAMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGDFITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHYLINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIVAQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLLLCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYILTLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMAHLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYLQTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWHRDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEIIEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGAIVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQVFSPSPSYSLSGTD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
173	Phosphorylation	RGPCTLETLINPSPS CCCEEEEHHCCCCCC	35.73	22210691
180	Phosphorylation	TLINPSPSVADVKIY HHCCCCCCCCCCEEC	33.98	22210691
256	Phosphorylation	YLPHLFPSFTKLTNI CHHHHCCCCHHHCCC	37.91	24719451
290	Phosphorylation	TRDNENIYSTKIPYM CCCCCCCCCCCCHHH	23.13	18083107
296	Phosphorylation	IYSTKIPYMAARVVF CCCCCCHHHHHHHHH	11.67	18083107
316	Phosphorylation	TFFLEKKYLTATQNT HHHHHHHCCCCCCCC	21.98	-
336	Phosphorylation	VLPKIIQTVGGGAVQ HHHHHHHHHCCCCHH	15.65	22210691
355	Phosphorylation	ELDGGGPTEQDKSHS CCCCCCCCCCCCCCC	49.94	23312004
360	Phosphorylation	GPTEQDKSHSNSSTL CCCCCCCCCCCCCCH	40.20	23312004
362	Phosphorylation	TEQDKSHSNSSTLSD CCCCCCCCCCCCHHH	45.56	23312004
364	Phosphorylation	QDKSHSNSSTLSDRR CCCCCCCCCCHHHHH	27.93	23312004
365	Phosphorylation	DKSHSNSSTLSDRRL CCCCCCCCCHHHHHC	37.30	23312004
366	Phosphorylation	KSHSNSSTLSDRRLS CCCCCCCCHHHHHCC	30.06	24719451
368	Phosphorylation	HSNSSTLSDRRLSNS CCCCCCHHHHHCCCC	29.20	23312004
373	Phosphorylation	TLSDRRLSNSSLCSI CHHHHHCCCCCCCCH	32.62	23401153
375	Phosphorylation	SDRRLSNSSLCSIEE HHHHCCCCCCCCHHH	22.70	23401153
376	Phosphorylation	DRRLSNSSLCSIEEE HHHCCCCCCCCHHHH	37.33	30266825
379	Phosphorylation	LSNSSLCSIEEEHRM CCCCCCCCHHHHHHH	38.02	30266825
388	Phosphorylation	EEEHRMVYEMVQRIL HHHHHHHHHHHHHHH	6.75	-
425	Ubiquitination	CEIAVTRKVVQVYRK CCEEEEHHHHHHHHH	37.07	-
461	Phosphorylation	DAEKLGFSETDSKEA HHHHHCCCCCCCCCC	37.48	23312004
463	Phosphorylation	EKLGFSETDSKEASS HHHCCCCCCCCCCCC	44.36	23312004
465	Phosphorylation	LGFSETDSKEASSES HCCCCCCCCCCCCCC	39.55	23312004
469	Phosphorylation	ETDSKEASSESSGHK CCCCCCCCCCCCCCC	35.41	23312004
473	Phosphorylation	KEASSESSGHKRSSS CCCCCCCCCCCCCCC	40.65	23312004
478	Phosphorylation	ESSGHKRSSSWGRTY CCCCCCCCCCCCCCE	33.26	27251275
479	Phosphorylation	SSGHKRSSSWGRTYS CCCCCCCCCCCCCEE	33.86	27251275
480	Phosphorylation	SGHKRSSSWGRTYSF CCCCCCCCCCCCEEH	34.49	16490346
484	Phosphorylation	RSSSWGRTYSFTSAM CCCCCCCCEEHHHHH	21.41	23403867
485	Phosphorylation	SSSWGRTYSFTSAMS CCCCCCCEEHHHHHH	10.63	23403867
486	Phosphorylation	SSWGRTYSFTSAMSR CCCCCCEEHHHHHHC	22.80	23401153
488	Phosphorylation	WGRTYSFTSAMSRGC CCCCEEHHHHHHCCC	15.05	23927012
489	Phosphorylation	GRTYSFTSAMSRGCV CCCEEHHHHHHCCCC	21.69	23403867
492	Phosphorylation	YSFTSAMSRGCVTEE EEHHHHHHCCCCCCC	25.82	23403867
497	Phosphorylation	AMSRGCVTEEENTNV HHHCCCCCCCCCCCH	41.58	28985074
674	Ubiquitination	KLSEQKEKKQRGKGC HHHHHHHHHHCCCCC	62.33	-
675	Ubiquitination	LSEQKEKKQRGKGCV HHHHHHHHHCCCCCE	46.44	-
679	Ubiquitination	KEKKQRGKGCVLDPQ HHHHHCCCCCEECCC	51.86	-
679	Methylation	KEKKQRGKGCVLDPQ HHHHHCCCCCEECCC	51.86	80503683
689	Phosphorylation	VLDPQKGTTVGRSFS EECCCCCCCCCCCEE	25.91	29514088
690	Phosphorylation	LDPQKGTTVGRSFSL ECCCCCCCCCCCEEE	29.63	29514088
694	Phosphorylation	KGTTVGRSFSLSWRS CCCCCCCCEEEEECC	17.17	30266825
696	Phosphorylation	TTVGRSFSLSWRSHP CCCCCCEEEEECCCC	23.81	23401153
698	Phosphorylation	VGRSFSLSWRSHPDV CCCCEEEEECCCCCC	21.17	30266825
701	Phosphorylation	SFSLSWRSHPDVTEP CEEEEECCCCCCCCC	32.87	28348404
713	Phosphorylation	TEPMRFRSATTSGAP CCCCCCCCCCCCCCC	27.53	25884760
715	Phosphorylation	PMRFRSATTSGAPGV CCCCCCCCCCCCCCH	23.81	29255136
716	Phosphorylation	MRFRSATTSGAPGVE CCCCCCCCCCCCCHH	25.53	29255136
717	Phosphorylation	RFRSATTSGAPGVEK CCCCCCCCCCCCHHH	28.71	23403867
764	Phosphorylation	QQQQVLRSSSTSDIP HHHHHHHCCCCCCCC	25.20	23403867
765	Phosphorylation	QQQVLRSSSTSDIPE HHHHHHCCCCCCCCC	31.07	26657352
766	Phosphorylation	QQVLRSSSTSDIPEP HHHHHCCCCCCCCCC	32.93	23401153
767	Phosphorylation	QVLRSSSTSDIPEPL HHHHCCCCCCCCCCC	32.16	25159151
768	Phosphorylation	VLRSSSTSDIPEPLC HHHCCCCCCCCCCCC	35.18	23403867
776	Phosphorylation	DIPEPLCSDSSQGQK CCCCCCCCCCCCCCC	48.48	23403867
778	Phosphorylation	PEPLCSDSSQGQKAE CCCCCCCCCCCCCCC	14.31	23403867
779	Phosphorylation	EPLCSDSSQGQKAEN CCCCCCCCCCCCCCC	43.23	23403867
813	Phosphorylation	KREHEGITILVRRSS CCHHCCEEEEEECCC	21.08	-
819	Phosphorylation	ITILVRRSSSPAELD EEEEEECCCCCCCCC	25.30	23401153
820	Phosphorylation	TILVRRSSSPAELDL EEEEECCCCCCCCCC	38.23	25159151
821	Phosphorylation	ILVRRSSSPAELDLK EEEECCCCCCCCCCH	29.40	23927012
834	Phosphorylation	LKDDLQQTQGKCRER CHHHHHHHHHHHHHH	26.74	24702127
844	Phosphorylation	KCRERQKSESTNSDT HHHHHHHHCCCCCCC	28.57	20736484
846	Phosphorylation	RERQKSESTNSDTTL HHHHHHCCCCCCCCC	39.72	20736484
847	Phosphorylation	ERQKSESTNSDTTLG HHHHHCCCCCCCCCC	34.39	20736484
849	Phosphorylation	QKSESTNSDTTLGCT HHHCCCCCCCCCCCC	36.10	20736484
902	Phosphorylation	PTDASNLTDSSECLT CCCHHHCCCCHHHCC	37.78	27251275
904	Phosphorylation	DASNLTDSSECLTDD CHHHCCCCHHHCCCC	23.85	27251275
905	Phosphorylation	ASNLTDSSECLTDDC HHHCCCCHHHCCCCC	34.83	27251275
980	Phosphorylation	AISLDNQSSPSPPVL EEECCCCCCCCCCCC	50.93	26657352
981	Phosphorylation	ISLDNQSSPSPPVLI EECCCCCCCCCCCCC	21.45	26657352
1091	Phosphorylation	AAARVLSTDILTAPR HHHHHHCCCCCCCCH	23.93	27732954
1095	Phosphorylation	VLSTDILTAPRSEAV HHCCCCCCCCHHHHH	34.64	27732954
1223	Phosphorylation	EKLQMFETSLPRKMA HHHHHHHHCCCHHHH	25.05	29449344
1224	Phosphorylation	KLQMFETSLPRKMAE HHHHHHHCCCHHHHH	29.22	22210691
1313	Phosphorylation	VCGSSTYTQQSHYIL HCCCCCCCCCCCEEE	21.88	30576142
1330	Phosphorylation	ADLSSTDYDPFLPLA HHCCCCCCCCCCCCC	26.13	30576142
1347	Phosphorylation	KSSEPVQYHSSAELG CCCCCCCCCCCCHHC	12.14	27642862
1349	Phosphorylation	SEPVQYHSSAELGNL CCCCCCCCCCHHCCC	26.72	26356563
1350	Phosphorylation	EPVQYHSSAELGNLL CCCCCCCCCHHCCCC	16.67	26356563
1457	Phosphorylation	GSPVGSLSDVRVIVR CCCCCCHHHEEEEEE	35.44	24719451
1467	Phosphorylation	RVIVRDISGKYSWDG EEEEEECCCCCCCCC	33.26	26657352
1470	Phosphorylation	VRDISGKYSWDGKVL EEECCCCCCCCCCEE	20.65	26657352
1493	Phosphorylation	APNGRNPSFLISSWH CCCCCCCCCEEEEEC	35.91	28348404
1508	Ubiquitination	RDTFGPQKDSSQVEE CCCCCCCCCHHHCCC	63.81	29967540
1574	Phosphorylation	QNAQEDEYIQSHNFD CCCCCCHHHHHCCCC	19.31	27642862
1587	Phosphorylation	FDSAMKVTSQGQPSP CCCCEEECCCCCCCC	15.15	25907765
1588	Phosphorylation	DSAMKVTSQGQPSPV CCCEEECCCCCCCCC	34.99	28450419
1593	Phosphorylation	VTSQGQPSPVEPRGP ECCCCCCCCCCCCCC	33.42	10574462
1640	Phosphorylation	RELKNLDSRQCRETH HHHCCCCHHHHHHHH	27.67	-
1646	Phosphorylation	DSRQCRETHKIAVFY CHHHHHHHHCEEEEE	14.76	-
1736	Ubiquitination	SDDSLTKKLRHLGND CCCHHHHHHHHCCCC	45.58	-
1839	Phosphorylation	FYEERALYLEAIIQN HHHHHHHHHHHHHHH	11.08	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
486	S	Phosphorylation	Kinase	AKT1	P31749	PSP
696	S	Phosphorylation	Kinase	PKB	P31749	Uniprot
715	T	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RGPA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RGPA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RGPA2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RGPA2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-820 AND SER-821, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Adipocytes contain a novel complex similar to the tuberous sclerosiscomplex."; Gridley S., Chavez J.A., Lane W.S., Lienhard G.E.; Cell. Signal. 18:1626-1632(2006). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RALGAPB,SUBCELLULAR LOCATION, AND PHOSPHORYLATION AT SER-486; SER-696 ANDTHR-715.	16490346 [Abstract]