| UniProt ID | ATX3_HUMAN | |
|---|---|---|
| UniProt AC | P54252 | |
| Protein Name | Ataxin-3 | |
| Gene Name | ATXN3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 361 | |
| Subcellular Localization | Nucleus matrix . Predominantly nuclear, but not exclusively, inner nuclear matrix. | |
| Protein Description | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. [PubMed: 12297501] | |
| Protein Sequence | MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | FHEKQEGSLCAQHCL CCCCCCCCHHHHHHH | 21.37 | - | |
| 27 | Phosphorylation | NNLLQGEYFSPVELS HHHHCCCCCCHHHHH | 19.04 | 28796482 | |
| 29 | Phosphorylation | LLQGEYFSPVELSSI HHCCCCCCHHHHHHH | 27.43 | 28796482 | |
| 54 | Phosphorylation | RMAEGGVTSEDYRTF HHHHCCCCHHHHHHH | 29.67 | 29978859 | |
| 55 | Phosphorylation | MAEGGVTSEDYRTFL HHHCCCCHHHHHHHH | 26.51 | 29978859 | |
| 58 | Phosphorylation | GGVTSEDYRTFLQQP CCCCHHHHHHHHCCC | 13.91 | 29978859 | |
| 60 | Phosphorylation | VTSEDYRTFLQQPSG CCHHHHHHHHCCCCC | 23.59 | - | |
| 62 (in isoform 3) | Ubiquitination | - | 4.58 | 21890473 | |
| 117 | Ubiquitination | RSFICNYKEHWFTVR CCCCCCCHHHEEEHH | 29.16 | 21890473 | |
| 117 (in isoform 1) | Ubiquitination | - | 29.16 | 21890473 | |
| 117 (in isoform 2) | Ubiquitination | - | 29.16 | 21890473 | |
| 135 (in isoform 3) | Ubiquitination | - | 28.11 | 21890473 | |
| 145 (in isoform 3) | Ubiquitination | - | 32.17 | 21890473 | |
| 151 (in isoform 3) | Ubiquitination | - | 4.40 | 21890473 | |
| 166 | Sumoylation | GYSIFVVKGDLPDCE CCEEEEEECCCCCCC | 41.21 | - | |
| 180 | Sulfoxidation | EADQLLQMIRVQQMH CHHHHHHHHHHHHHC | 1.82 | 21406390 | |
| 190 (in isoform 2) | Ubiquitination | - | 53.33 | 21890473 | |
| 190 (in isoform 1) | Ubiquitination | - | 53.33 | 21890473 | |
| 190 | Ubiquitination | VQQMHRPKLIGEELA HHHHCCCCHHHHHHH | 53.33 | 21890473 | |
| 200 | Ubiquitination | GEELAQLKEQRVHKT HHHHHHHHHHHCCCC | 39.46 | 21890473 | |
| 200 | Acetylation | GEELAQLKEQRVHKT HHHHHHHHHHHCCCC | 39.46 | 25953088 | |
| 200 (in isoform 1) | Ubiquitination | - | 39.46 | 21890473 | |
| 200 (in isoform 2) | Ubiquitination | - | 39.46 | 21890473 | |
| 206 | Ubiquitination | LKEQRVHKTDLERVL HHHHHCCCCHHHHHH | 40.66 | 21890473 | |
| 206 (in isoform 1) | Ubiquitination | - | 40.66 | 21890473 | |
| 206 (in isoform 2) | Ubiquitination | - | 40.66 | 21890473 | |
| 219 | Phosphorylation | VLEANDGSGMLDEDE HHHHCCCCCCCCCCH | 24.72 | 21815630 | |
| 236 (in isoform 3) | Ubiquitination | - | 26.72 | 21890473 | |
| 236 | Phosphorylation | LQRALALSRQEIDME HHHHHHHHHHHCCCC | 26.72 | 27251275 | |
| 242 | Sulfoxidation | LSRQEIDMEDEEADL HHHHHCCCCCHHHHH | 9.56 | 21406390 | |
| 256 | Phosphorylation | LRRAIQLSMQGSSRN HHHHHHHHHCCCCCC | 7.84 | 17434145 | |
| 257 | Sulfoxidation | RRAIQLSMQGSSRNI HHHHHHHHCCCCCCC | 7.71 | 21406390 | |
| 260 | Phosphorylation | IQLSMQGSSRNISQD HHHHHCCCCCCCCCC | 14.83 | 28857561 | |
| 261 | Phosphorylation | QLSMQGSSRNISQDM HHHHCCCCCCCCCCC | 35.85 | 28857561 | |
| 265 | Phosphorylation | QGSSRNISQDMTQTS CCCCCCCCCCCHHCC | 24.55 | 25159151 | |
| 268 | Sulfoxidation | SRNISQDMTQTSGTN CCCCCCCCHHCCCCC | 2.01 | 21406390 | |
| 269 | Phosphorylation | RNISQDMTQTSGTNL CCCCCCCHHCCCCCC | 36.66 | 28857561 | |
| 271 | Phosphorylation | ISQDMTQTSGTNLTS CCCCCHHCCCCCCCH | 21.69 | 29888752 | |
| 272 | Phosphorylation | SQDMTQTSGTNLTSE CCCCHHCCCCCCCHH | 33.53 | 21815630 | |
| 274 | Phosphorylation | DMTQTSGTNLTSEEL CCHHCCCCCCCHHHH | 27.16 | 27486199 | |
| 278 | Phosphorylation | TSGTNLTSEELRKRR CCCCCCCHHHHHHHH | 32.04 | - | |
| 291 (in isoform 2) | Ubiquitination | - | 43.43 | 21890473 | |
| 291 (in isoform 1) | Ubiquitination | - | 43.43 | 21890473 | |
| 291 | Ubiquitination | RREAYFEKQQQKQQQ HHHHHHHHHHHHHHH | 43.43 | 21890473 | |
| 328 | Phosphorylation | TSSGALGSDLGDAMS CCCCCCCCCHHHCCC | 30.43 | - | |
| 335 | Phosphorylation | SDLGDAMSEEDMLQA CCHHHCCCHHHHHHH | 27.92 | - | |
| 347 | Phosphorylation | LQAAVTMSLETVRND HHHHHHHCHHHHHHH | 4.65 | - | |
| 360 | Acetylation | NDLKTEGKK------ HHHHHCCCC------ | 18.11 | 36760807 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 236 | S | Phosphorylation | Kinase | CSNK2A1 | P68400 | GPS |
| 236 | S | Phosphorylation | Kinase | CK2-FAMILY | - | GPS |
| 256 | S | Phosphorylation | Kinase | GSK3B | P49841 | PSP |
| 335 | S | Phosphorylation | Kinase | CSNK2A1 | P68400 | GPS |
| 335 | S | Phosphorylation | Kinase | CK2-FAMILY | - | GPS |
| 347 | S | Phosphorylation | Kinase | CSNK2A1 | P68400 | GPS |
| 347 | S | Phosphorylation | Kinase | CK2-FAMILY | - | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:24106274 |
| - | K | Ubiquitination | E3 ubiquitin ligase | SMURF1 | Q9HCE7 | PMID:20804422 |
| - | K | Ubiquitination | E3 ubiquitin ligase | UBE4B | O95155 | PMID:14749733 |
| - | K | Ubiquitination | E3 ubiquitin ligase | MARCHF8 | Q5T0T0 | PMID:22199232 |
| - | K | Ubiquitination | E3 ubiquitin ligase | PRKN | O60260 | PMID:22199232 |
| - | K | Ubiquitination | E3 ubiquitin ligase | MARCHF5 | Q9NX47 | PMID:20851218 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATX3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 109150 | Spinocerebellar ataxia 3 (SCA3) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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