ALG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG1_HUMAN
• UniProt AC: Q9BT22
• Protein Name: Chitobiosyldiphosphodolichol beta-mannosyltransferase
• Gene Name: ALG1
• Organism: Homo sapiens (Human).
• Sequence Length: 464
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER..
• Protein Sequence: MAASCLVLLALCLLLPLLLLGGWKRWRRGRAARHVVAVVLGDVGRSPRMQYHALSLAMHGFSVTLLGFCNSKPHDELLQNNRIQIVGLTELQSLAVGPRVFQYGVKVVLQAMYLLWKLMWREPGAYIFLQNPPGLPSIAVCWFVGCLCGSKLVIDWHNYGYSIMGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDLADNWHIRAVTVYDKPASFFKETPLDLQHRLFMKLGSMHSPFRARSEPEDPVTERSAFTERDAGSGLVTRLRERPALLVSSTSWTEDEDFSILLAALEKFEQLTLDGHNLPSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLEAEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSEELAAQLQMLFSNFPDPAGKLNQFRKNLRESQQLRWDESWVQTVLPLVMDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	VLGDVGRSPRMQYHA EECCCCCCHHHHHHH	15.78	21712546
68	Ubiquitination	FSVTLLGFCNSKPHD CEEEEEHHCCCCCCH	3.44	22817900
72	Ubiquitination	LLGFCNSKPHDELLQ EEHHCCCCCCHHHHH	32.17	21890473
72	Ubiquitination	LLGFCNSKPHDELLQ EEHHCCCCCCHHHHH	32.17	21890473
106	Ubiquitination	RVFQYGVKVVLQAMY HHHHHHHHHHHHHHH	23.43	21890473
106	Ubiquitination	RVFQYGVKVVLQAMY HHHHHHHHHHHHHHH	23.43	21890473
112	Ubiquitination	VKVVLQAMYLLWKLM HHHHHHHHHHHHHHH	1.24	21890473
112	Ubiquitination	VKVVLQAMYLLWKLM HHHHHHHHHHHHHHH	1.24	21890473
113	Phosphorylation	KVVLQAMYLLWKLMW HHHHHHHHHHHHHHC	11.14	28634298
125	Ubiquitination	LMWREPGAYIFLQNP HHCCCCCEEEEECCC	12.64	-
125	Ubiquitination	LMWREPGAYIFLQNP HHCCCCCEEEEECCC	12.64	21987572
179	Ubiquitination	HPLVLLAKWYEKFFG CHHHHHHHHHHHHHH	50.72	22817900
183	Ubiquitination	LLAKWYEKFFGRLSH HHHHHHHHHHHHHHH	30.23	21890473
217	Ubiquitination	RAVTVYDKPASFFKE EEEEEECCCHHHHCC	25.46	21890473
223	Ubiquitination	DKPASFFKETPLDLQ CCCHHHHCCCCCCHH	59.68	22817900
236	Ubiquitination	LQHRLFMKLGSMHSP HHHHHHHHHCCCCCC	42.22	21987572
239	Phosphorylation	RLFMKLGSMHSPFRA HHHHHHCCCCCCCCC	24.61	18691976
242	Phosphorylation	MKLGSMHSPFRARSE HHHCCCCCCCCCCCC	19.66	26931382
284	Ubiquitination	PALLVSSTSWTEDED CEEEEECCCCCCCCC	22.30	21963094
284	Ubiquitination	PALLVSSTSWTEDED CEEEEECCCCCCCCC	22.30	-
322	Ubiquitination	LVCVITGKGPLREYY EEEEEECCCHHHHHH	49.02	-
382	Ubiquitination	LPMKVVDMFGCCLPV CCHHHHHHHCCCHHH	1.78	21963094
395	Ubiquitination	PVCAVNFKCLHELVK HHHHHCHHHHHHHHH	30.59	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ALG1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00118: Congenital disorders of glycosylation (CDG) type I
• OMIM Disease
• 608540: Congenital disorder of glycosylation 1K (CDG1K)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, AND MASSSPECTROMETRY.
PubMed: 18691976