DHB11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHB11_HUMAN
• UniProt AC: Q8NBQ5
• Protein Name: Estradiol 17-beta-dehydrogenase 11
• Gene Name: HSD17B11
• Organism: Homo sapiens (Human).
• Sequence Length: 300
• Subcellular Localization: Secreted .
• Protein Description: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma..
• Protein Sequence: MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKFLLDILL ------CHHHHHHHH	44.73	20167786
33	Phosphorylation	FIPKRRKSVTGEIVL HCCCCCCCCCCCEEE	24.09	26657352
35	Phosphorylation	PKRRKSVTGEIVLIT CCCCCCCCCCEEEEC	35.87	28450419
42	Phosphorylation	TGEIVLITGAGHGIG CCCEEEECCCCCCHH	19.47	28102081
58	Ubiquitination	LTAYEFAKLKSKLVL HHHHHHHHHHCEEEE	62.86	33845483
60	Trimethylation	AYEFAKLKSKLVLWD HHHHHHHHCEEEEEE	44.85	-
60	Methylation	AYEFAKLKSKLVLWD HHHHHHHHCEEEEEE	44.85	-
60	Ubiquitination	AYEFAKLKSKLVLWD HHHHHHHHCEEEEEE	44.85	22817900
62	Trimethylation	EFAKLKSKLVLWDIN HHHHHHCEEEEEECH	40.82	-
62	Ubiquitination	EFAKLKSKLVLWDIN HHHHHHCEEEEEECH	40.82	21890473
62	Methylation	EFAKLKSKLVLWDIN HHHHHHCEEEEEECH	40.82	-
62	Acetylation	EFAKLKSKLVLWDIN HHHHHHCEEEEEECH	40.82	25953088
62	Malonylation	EFAKLKSKLVLWDIN HHHHHHCEEEEEECH	40.82	26320211
70	Methylation	LVLWDINKHGLEETA EEEEECHHCCHHHHH	39.11	-
70	Malonylation	LVLWDINKHGLEETA EEEEECHHCCHHHHH	39.11	26320211
70	Acetylation	LVLWDINKHGLEETA EEEEECHHCCHHHHH	39.11	23236377
70	Trimethylation	LVLWDINKHGLEETA EEEEECHHCCHHHHH	39.11	-
70	Ubiquitination	LVLWDINKHGLEETA EEEEECHHCCHHHHH	39.11	21906983
79	Ubiquitination	GLEETAAKCKGLGAK CHHHHHHHCCCCCCE	33.73	29967540
86	Malonylation	KCKGLGAKVHTFVVD HCCCCCCEEEEEEEE	32.52	26320211
86	Ubiquitination	KCKGLGAKVHTFVVD HCCCCCCEEEEEEEE	32.52	29967540
89	Phosphorylation	GLGAKVHTFVVDCSN CCCCEEEEEEEECCC	22.55	28348404
95	Phosphorylation	HTFVVDCSNREDIYS EEEEEECCCCHHHHH	34.16	28348404
101	Phosphorylation	CSNREDIYSSAKKVK CCCCHHHHHHCHHHH	14.64	28348404
102	Phosphorylation	SNREDIYSSAKKVKA CCCHHHHHHCHHHHC	24.93	28348404
103	Phosphorylation	NREDIYSSAKKVKAE CCHHHHHHCHHHHCE	27.43	28348404
105	2-Hydroxyisobutyrylation	EDIYSSAKKVKAEIG HHHHHHCHHHHCEEC	61.11	-
105	Ubiquitination	EDIYSSAKKVKAEIG HHHHHHCHHHHCEEC	61.11	27667366
106	Ubiquitination	DIYSSAKKVKAEIGD HHHHHCHHHHCEECC	49.00	22817900
108	Ubiquitination	YSSAKKVKAEIGDVS HHHCHHHHCEECCEE	49.54	22817900
188	Phosphorylation	FLLAYCSSKFAAVGF HHHHHHCCCCHHCCC	28.38	-
227	Ubiquitination	FVNTGFIKNPSTSLG CCCCCCCCCCCCCCC	61.62	29967540
230	Phosphorylation	TGFIKNPSTSLGPTL CCCCCCCCCCCCCCC	39.77	27050516
232	Phosphorylation	FIKNPSTSLGPTLEP CCCCCCCCCCCCCCH	35.35	27050516

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHB11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHB11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHB11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DHB11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.