KBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBL_HUMAN
• UniProt AC: O75600
• Protein Name: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
• Gene Name: GCAT
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Mitochondrion. Nucleus . Translocates to the nucleus upon cold and osmotic stress.
• Protein Sequence: MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIVQSMAAKTQRFRSKMEAAGFTISGASHPICPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAFVEVGRLHGALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Succinylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	-
45	Succinylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	-
45	Acetylation	IRGAGTWKSERVITS CCCCCCEECCEEEEC	42.13	-
51	Phosphorylation	WKSERVITSRQGPHI EECCEEEECCCCCCE	18.26	20068231
52	Phosphorylation	KSERVITSRQGPHIR ECCEEEECCCCCCEE	16.10	23532336
100	Phosphorylation	EEFGAGLSSVRFICG HHHCCCHHHEEEEEC	26.35	24719451
101	Phosphorylation	EFGAGLSSVRFICGT HHCCCHHHEEEEECC	23.50	24275569
113	Ubiquitination	CGTQSIHKNLEAKIA ECCHHHHHCHHHHHH	62.65	-
118	Ubiquitination	IHKNLEAKIARFHQR HHHCHHHHHHHHHHC	27.76	-
187	Succinylation	DMADLEAKLQEAQKH CHHHHHHHHHHHHHH	41.13	-
187	Succinylation	DMADLEAKLQEAQKH CHHHHHHHHHHHHHH	41.13	-
187	Acetylation	DMADLEAKLQEAQKH CHHHHHHHHHHHHHH	41.13	25953088
187	Ubiquitination	DMADLEAKLQEAQKH CHHHHHHHHHHHHHH	41.13	-
265	N6-(pyridoxal phosphate)lysine	IINSTLGKALGGASG EEECHHHHHHCCCCC	43.48	-
265	Other	IINSTLGKALGGASG EEECHHHHHHCCCCC	43.48	-
274	Phosphorylation	LGGASGGYTTGPGPL HCCCCCCCCCCCCHH	12.49	-
292	Phosphorylation	LRQRARPYLFSNSLP HHHHCCHHHHCCCCC	18.15	22461510
307	Phosphorylation	PAVVGCASKALDLLM HHHHHHHHHHHHHHH	23.65	22461510
326	Succinylation	IVQSMAAKTQRFRSK HHHHHHHHHHHHHHH	35.34	-
326	Succinylation	IVQSMAAKTQRFRSK HHHHHHHHHHHHHHH	35.34	-
333	Ubiquitination	KTQRFRSKMEAAGFT HHHHHHHHHHHCCEE	36.18	-
368	Succinylation	RMADDMLKRGIFVIG HHHHHHHHCCEEEEE	41.77	-
368	Acetylation	RMADDMLKRGIFVIG HHHHHHHHCCEEEEE	41.77	2380539
368	Succinylation	RMADDMLKRGIFVIG HHHHHHHHCCEEEEE	41.77	-
383	Succinylation	FSYPVVPKGKARIRV ECCCCCCCCEEEEEE	62.53	-
383	Succinylation	FSYPVVPKGKARIRV ECCCCCCCCEEEEEE	62.53	-
383	Acetylation	FSYPVVPKGKARIRV ECCCCCCCCEEEEEE	62.53	-
397	Phosphorylation	VQISAVHSEEDIDRC EEEEECCCHHHHHHH	35.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	21988832
TEAD1_HUMAN	TEAD1	physical	21988832
CLPX_HUMAN	CLPX	physical	26186194
LONM_HUMAN	LONP1	physical	26186194
MCCA_HUMAN	MCCC1	physical	26186194
EMB_HUMAN	EMB	physical	26186194
NDUS6_HUMAN	NDUFS6	physical	26186194
EMB_HUMAN	EMB	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
MCCA_HUMAN	MCCC1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.