TTC38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTC38_HUMAN
• UniProt AC: Q5R3I4
• Protein Name: Tetratricopeptide repeat protein 38
• Gene Name: TTC38
• Organism: Homo sapiens (Human).
• Sequence Length: 469
• Protein Sequence: MAAASPLRDCQAWKDARLPLSTTSNEACKLFDATLTQYVKWTNDKSLGGIEGCLSKLKAADPTFVMGHAMATGLVLIGTGSSVKLDKELDLAVKTMVEISRTQPLTRREQLHVSAVETFANGNFPKACELWEQILQDHPTDMLALKFSHDAYFYLGYQEQMRDSVARIYPFWTPDIPLSSYVKGIYSFGLMETNFYDQAEKLAKEALSINPTDAWSVHTVAHIHEMKAEIKDGLEFMQHSETFWKDSDMLACHNYWHWALYLIEKGEYEAALTIYDTHILPSLQANDAMLDVVDSCSMLYRLQMEGVSVGQRWQDVLPVARKHSRDHILLFNDAHFLMASLGAHDPQTTQELLTTLRDASESPGENCQHLLARDVGLPLCQALVEAEDGNPDRVLELLLPIRYRIVQLGGSNAQRDVFNQLLIHAALNCTSSVHKNVARSLLMERDALKPNSPLTERLIRKAATVHLMQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAASPLRD ------CCCCCCCCC	16.25	20068231
5	Phosphorylation	---MAAASPLRDCQA ---CCCCCCCCCCHH	21.53	23401153
14	Ubiquitination	LRDCQAWKDARLPLS CCCCHHHCCCCCCCC	44.52	29967540
29	Ubiquitination	TTSNEACKLFDATLT CCCHHHHHHHHCHHH	60.27	21963094
40	Ubiquitination	ATLTQYVKWTNDKSL CHHHHHEECCCCCCC	43.28	21963094
45	Ubiquitination	YVKWTNDKSLGGIEG HEECCCCCCCCCHHH	50.04	21963094
56	Ubiquitination	GIEGCLSKLKAADPT CHHHHHHHHHHCCCC	40.85	21963094
58	Ubiquitination	EGCLSKLKAADPTFV HHHHHHHHHCCCCCH	45.31	22817900
63	Phosphorylation	KLKAADPTFVMGHAM HHHHCCCCCHHCCCC	29.43	22210691
87	Ubiquitination	GSSVKLDKELDLAVK CCCCCCHHHHHHHHH	71.29	29967540
136	Ubiquitination	ELWEQILQDHPTDML HHHHHHHHHCCCCEE	48.90	21963094
139	Ubiquitination	EQILQDHPTDMLALK HHHHHHCCCCEEEHH	38.08	22817900
201	Ubiquitination	NFYDQAEKLAKEALS CCHHHHHHHHHHHHC	57.68	21963094
204	Ubiquitination	DQAEKLAKEALSINP HHHHHHHHHHHCCCC	54.69	22817900
208	Phosphorylation	KLAKEALSINPTDAW HHHHHHHCCCCCCCC	27.63	-
227	Ubiquitination	VAHIHEMKAEIKDGL HHHHHHHHHHHHHHH	39.62	29967540
362	Phosphorylation	TLRDASESPGENCQH HHHHHHCCCCCCHHH	35.39	29214152
384	Ubiquitination	LPLCQALVEAEDGNP HHHHHHHHHCCCCCH	8.00	22817900
449	Ubiquitination	LMERDALKPNSPLTE HHHCCCCCCCCHHHH	43.82	21906983
452	Phosphorylation	RDALKPNSPLTERLI CCCCCCCCHHHHHHH	29.79	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTC38_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTC38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTC38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR4_HUMAN	PFAS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330