FST_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FST_HUMAN
• UniProt AC: P19883
• Protein Name: Follistatin
• Gene Name: FST
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Subcellular Localization: Secreted.
• Protein Description: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)..
• Protein Sequence: MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	N-linked_Glycosylation	VCAPDCSNITWKGPV EECCCCCCCCEECCC	41.88	UniProtKB CARBOHYD
201	Phosphorylation	RICPEPASSEQYLCG CCCCCCCCCCCEEEC	45.16	25002506
202	Phosphorylation	ICPEPASSEQYLCGN CCCCCCCCCCEEECC	30.72	25002506
205	Phosphorylation	EPASSEQYLCGNDGV CCCCCCCEEECCCCC	10.41	25002506
213	Phosphorylation	LCGNDGVTYSSACHL EECCCCCCHHHHHHH	24.18	25002506
214	Phosphorylation	CGNDGVTYSSACHLR ECCCCCCHHHHHHHH	9.75	25002506
215	Phosphorylation	GNDGVTYSSACHLRK CCCCCCHHHHHHHHH	11.33	25002506
216	Phosphorylation	NDGVTYSSACHLRKA CCCCCHHHHHHHHHH	25.22	25002506
230	Phosphorylation	ATCLLGRSIGLAYEG HHHHHCCHHHEEECC	21.14	29970186
277	Phosphorylation	CDELCPDSKSDEPVC CHHHCCCCCCCCCCC	21.14	27251275
288	N-linked_Glycosylation	EPVCASDNATYASEC CCCCCCCCCCCHHHH	31.52	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FST_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FST_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FST_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
INHBA_HUMAN	INHBA	physical	16198295
BMR1A_HUMAN	BMPR1A	physical	16198295
BMPR2_HUMAN	BMPR2	physical	16198295

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.