CRUM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRUM3_HUMAN
• UniProt AC: Q9BUF7
• Protein Name: Protein crumbs homolog 3
• Gene Name: CRB3
• Organism: Homo sapiens (Human).
• Sequence Length: 120
• Subcellular Localization: Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
• Protein Description: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions..
• Protein Sequence: MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTEGTYRPSSEEQVGARVPPTPNLKLPPEERLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	N-linked_Glycosylation	QTTSANENSTVLPSS EECCCCCCCCCCCCC	42.67	12527193
36	N-linked_Glycosylation	QTTSANENSTVLPSS EECCCCCCCCCCCCC	42.67	12527193
89	Phosphorylation	KLREKRQTEGTYRPS HHHHHHCCCCCCCCC	40.18	23312004
92	Phosphorylation	EKRQTEGTYRPSSEE HHHCCCCCCCCCCHH	15.32	28152594
93	Phosphorylation	KRQTEGTYRPSSEEQ HHCCCCCCCCCCHHH	31.23	28152594
96	Phosphorylation	TEGTYRPSSEEQVGA CCCCCCCCCHHHHCC	41.19	25849741
97	Phosphorylation	EGTYRPSSEEQVGAR CCCCCCCCHHHHCCC	48.08	25849741
108	Phosphorylation	VGARVPPTPNLKLPP HCCCCCCCCCCCCCH	20.81	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRUM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRUM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRUM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR83_HUMAN	WDR83	physical	23439680
PAR6B_HUMAN	PARD6B	physical	23439680

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mammalian Crumbs3 is a small transmembrane protein linked to proteinassociated with Lin-7 (Pals1).";
Makarova O., Roh M.H., Liu C.-J., Laurinec S., Margolis B.;
Gene 302:21-29(2003).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY,INTERACTION WITH MPP5 AND INADL, MUTAGENESIS OF ASN-36, SUBCELLULARLOCATION, AND GLYCOSYLATION AT ASN-36.
PubMed: 12527193