dbPTM

ZN592_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN592_HUMAN
UniProt AC	Q92610
Protein Name	Zinc finger protein 592
Gene Name	ZNF592
Organism	Homo sapiens (Human).
Sequence Length	1267
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MGDMKTPDFDDLLAAFDIPDPTSLDAKEAIQTPSEENESPLKPPGICMDESVSLSHSGSAPDVPAVSVIVKNTSRQESFEAEKDHITPSLLHNGFRGSDLPPDPHNCGKFDSTFMNGDSARSFPGKLEPPKSEPLPTFNQFSPISSPEPEDPIKDNGFGIKPKHSDSYFPPPLGCGAVGGPVLEALAKFPVPELHMFDHFCKKEPKPEPLPLGSQQEHEQSGQNTVEPHKDPDATRFFGEALEFNSHPSNSIGESKGLARELGTCSSVPPRQRLKPAHSKLSSCVAALVALQAKRVASVTKEDQPGHTKDLSGPTKESSKGSPKMPKSPKSPRSPLEATRKSIKPSDSPRSICSDSSSKGSPSVAASSPPAIPKVRIKTIKTSSGEIKRTVTRILPDPDDPSKSPVGSPLGSAIAEAPSEMPGDEVPVEEHFPEAGTNSGSPQGARKGDESMTKASDSSSPSCSSGPRVPKGAAPGSQTGKKQQSTALQASTLAPANLLPKAVHLANLNLVPHSVAASVTAKSSVQRRSQPQLTQMSVPLVHQVKKAAPLIVEVFNKVLHSSNPVPLYAPNLSPPADSRIHVPASGYCCLECGDAFALEKSLSQHYGRRSVHIEVLCTLCSKTLLFFNKCSLLRHARDHKSKGLVMQCSQLLVKPISADQMFVSAPVNSTAPAAPAPSSSPKHGLTSGSASPPPPALPLYPDPVRLIRYSIKCLECHKQMRDYMVLAAHFQRTTEETEGLTCQVCQMLLPNQCSFCAHQRIHAHKSPYCCPECGVLCRSAYFQTHVKENCLHYARKVGYRCIHCGVVHLTLALLKSHIQERHCQVFHKCAFCPMAFKTASSTADHSATQHPTQPHRPSQLIYKCSCEMVFNKKRHIQQHFYQNVSKTQVGVFKCPECPLLFVQKPELMQHVKSTHGVPRNVDELSSLQSSADTSSSRPGSRVPTEPPATSVAARSSSLPSGRWGRPEAHRRVEARPRLRNTGWTCQECQEWVPDRESYVSHMKKSHGRTLKRYPCRQCEQSFHTPNSLRKHIRNNHDTVKKFYTCGYCTEDSPSFPRPSLLESHISLMHGIRNPDLSQTSKVKPPGGHSPQVNHLKRPVSGVGDAPGTSNGATVSSTKRHKSLFQCAKCSFATDSGLEFQSHIPQHQVDSSTAQCLLCGLCYTSASSLSRHLFIVHKVRDQEEEEEEEAAAAEMAVEVAEPEEGSGEEVPMETRENGLEECAGEPLSADPEARRLLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGDMKTPDFDDLL --CCCCCCCCHHHHH	22.81	22115753
22	Phosphorylation	AFDIPDPTSLDAKEA HCCCCCCCCCCHHHH	49.67	20068231
23	Phosphorylation	FDIPDPTSLDAKEAI CCCCCCCCCCHHHHC	29.64	20068231
32	Phosphorylation	DAKEAIQTPSEENES CHHHHCCCCCCCCCC	23.75	26074081
34	Phosphorylation	KEAIQTPSEENESPL HHHCCCCCCCCCCCC	62.01	26074081
39	Phosphorylation	TPSEENESPLKPPGI CCCCCCCCCCCCCCE	47.30	26074081
51	Phosphorylation	PGICMDESVSLSHSG CCEECCCCCCCCCCC	16.85	24275569
53	Phosphorylation	ICMDESVSLSHSGSA EECCCCCCCCCCCCC	33.17	22210691
55	Phosphorylation	MDESVSLSHSGSAPD CCCCCCCCCCCCCCC	14.22	22210691
73	Phosphorylation	VSVIVKNTSRQESFE EEEEEECCCCCHHHH	21.40	23403867
74	Phosphorylation	SVIVKNTSRQESFEA EEEEECCCCCHHHHH	41.16	28464451
78	Phosphorylation	KNTSRQESFEAEKDH ECCCCCHHHHHHHHC	21.76	28355574
87	Phosphorylation	EAEKDHITPSLLHNG HHHHHCCCHHHCCCC	11.91	28464451
89	Phosphorylation	EKDHITPSLLHNGFR HHHCCCHHHCCCCCC	34.61	29978859
132	Phosphorylation	GKLEPPKSEPLPTFN CCCCCCCCCCCCCCC	50.66	20068231
137	Phosphorylation	PKSEPLPTFNQFSPI CCCCCCCCCCCCCCC	42.79	21955146
142	Phosphorylation	LPTFNQFSPISSPEP CCCCCCCCCCCCCCC	16.15	26503892
145	Phosphorylation	FNQFSPISSPEPEDP CCCCCCCCCCCCCCC	43.13	26503892
146	Phosphorylation	NQFSPISSPEPEDPI CCCCCCCCCCCCCCC	33.72	26503892
202	Sumoylation	HMFDHFCKKEPKPEP HCCCCCCCCCCCCCC	60.26	28112733
206	Sumoylation	HFCKKEPKPEPLPLG CCCCCCCCCCCCCCC	64.20	28112733
230	Ubiquitination	QNTVEPHKDPDATRF CCCCCCCCCCCHHHH	80.03	29967540
256	Ubiquitination	SNSIGESKGLARELG CCCHHCHHHHHHHHC	54.35	32015554
266	Phosphorylation	ARELGTCSSVPPRQR HHHHCCCCCCCHHHH	33.92	-
267	Phosphorylation	RELGTCSSVPPRQRL HHHCCCCCCCHHHHC	40.57	19413330
280	Acetylation	RLKPAHSKLSSCVAA HCCCCHHHHHHHHHH	42.39	25953088
298	Phosphorylation	LQAKRVASVTKEDQP HHHHHHHCCCCCCCC	27.71	23911959
300	Phosphorylation	AKRVASVTKEDQPGH HHHHHCCCCCCCCCC	26.65	24719451
301	Ubiquitination	KRVASVTKEDQPGHT HHHHCCCCCCCCCCC	58.08	29967540
308	Phosphorylation	KEDQPGHTKDLSGPT CCCCCCCCCCCCCCC	31.97	22985185
312	Phosphorylation	PGHTKDLSGPTKESS CCCCCCCCCCCCCCC	53.51	29396449
315	Phosphorylation	TKDLSGPTKESSKGS CCCCCCCCCCCCCCC	51.47	26434776
318	Phosphorylation	LSGPTKESSKGSPKM CCCCCCCCCCCCCCC	38.62	26434776
319	Phosphorylation	SGPTKESSKGSPKMP CCCCCCCCCCCCCCC	41.97	24719451
322	Phosphorylation	TKESSKGSPKMPKSP CCCCCCCCCCCCCCC	25.69	27422710
328	Phosphorylation	GSPKMPKSPKSPRSP CCCCCCCCCCCCCCH	31.52	21712546
331	Phosphorylation	KMPKSPKSPRSPLEA CCCCCCCCCCCHHHH	29.00	25159151
334	Phosphorylation	KSPKSPRSPLEATRK CCCCCCCCHHHHHHH	36.90	30266825
339	Phosphorylation	PRSPLEATRKSIKPS CCCHHHHHHHCCCCC	29.29	27794612
342	Phosphorylation	PLEATRKSIKPSDSP HHHHHHHCCCCCCCC	32.33	30266825
346	Phosphorylation	TRKSIKPSDSPRSIC HHHCCCCCCCCCCCC	45.80	23401153
348	Phosphorylation	KSIKPSDSPRSICSD HCCCCCCCCCCCCCC	26.93	23401153
351	Phosphorylation	KPSDSPRSICSDSSS CCCCCCCCCCCCCCC	31.19	23403867
354	Phosphorylation	DSPRSICSDSSSKGS CCCCCCCCCCCCCCC	38.57	23403867
356	Phosphorylation	PRSICSDSSSKGSPS CCCCCCCCCCCCCCC	21.88	23403867
357	Phosphorylation	RSICSDSSSKGSPSV CCCCCCCCCCCCCCH	40.85	23403867
358	Phosphorylation	SICSDSSSKGSPSVA CCCCCCCCCCCCCHH	45.01	23403867
361	Phosphorylation	SDSSSKGSPSVAASS CCCCCCCCCCHHHCC	20.10	25159151
363	Phosphorylation	SSSKGSPSVAASSPP CCCCCCCCHHHCCCC	26.53	25159151
367	Phosphorylation	GSPSVAASSPPAIPK CCCCHHHCCCCCCCE	33.37	30266825
368	Phosphorylation	SPSVAASSPPAIPKV CCCHHHCCCCCCCEE	30.12	30266825
382	Phosphorylation	VRIKTIKTSSGEIKR EEEEEEECCCCCEEE	25.03	25159151
383	Phosphorylation	RIKTIKTSSGEIKRT EEEEEECCCCCEEEE	31.20	25159151
384	Phosphorylation	IKTIKTSSGEIKRTV EEEEECCCCCEEEEE	45.75	25159151
402	Phosphorylation	LPDPDDPSKSPVGSP CCCCCCCCCCCCCCC	53.40	22210691
404	Phosphorylation	DPDDPSKSPVGSPLG CCCCCCCCCCCCCCC	29.20	18669648
408	Phosphorylation	PSKSPVGSPLGSAIA CCCCCCCCCCCHHHH	19.72	18669648
412	Phosphorylation	PVGSPLGSAIAEAPS CCCCCCCHHHHCCCC	24.96	27251275
419	Phosphorylation	SAIAEAPSEMPGDEV HHHHCCCCCCCCCCC	54.28	23909892
437	Phosphorylation	EHFPEAGTNSGSPQG HHCCCCCCCCCCCCC	33.00	18669648
439	Phosphorylation	FPEAGTNSGSPQGAR CCCCCCCCCCCCCCC	40.25	26074081
441	Phosphorylation	EAGTNSGSPQGARKG CCCCCCCCCCCCCCC	17.55	26074081
451	Phosphorylation	GARKGDESMTKASDS CCCCCCHHCCCCCCC	36.17	21712546
454	Ubiquitination	KGDESMTKASDSSSP CCCHHCCCCCCCCCC	36.93	24816145
456	Phosphorylation	DESMTKASDSSSPSC CHHCCCCCCCCCCCC	39.31	29255136
458	Phosphorylation	SMTKASDSSSPSCSS HCCCCCCCCCCCCCC	30.16	29255136
459	Phosphorylation	MTKASDSSSPSCSSG CCCCCCCCCCCCCCC	51.78	29255136
460	Phosphorylation	TKASDSSSPSCSSGP CCCCCCCCCCCCCCC	25.45	23401153
462	Phosphorylation	ASDSSSPSCSSGPRV CCCCCCCCCCCCCCC	28.69	29255136
464	Phosphorylation	DSSSPSCSSGPRVPK CCCCCCCCCCCCCCC	42.54	29255136
465	Phosphorylation	SSSPSCSSGPRVPKG CCCCCCCCCCCCCCC	58.08	29255136
477	O-linked_Glycosylation	PKGAAPGSQTGKKQQ CCCCCCCCCCCCHHH	24.41	30379171
514	O-linked_Glycosylation	NLNLVPHSVAASVTA CCCCCCHHHHHHHHC	13.84	30379171
518	O-linked_Glycosylation	VPHSVAASVTAKSSV CCHHHHHHHHCCHHH	15.40	30379171
520	O-linked_Glycosylation	HSVAASVTAKSSVQR HHHHHHHHCCHHHHH	26.35	30379171
529	Phosphorylation	KSSVQRRSQPQLTQM CHHHHHCCCCCCCCC	48.69	25159151
534	Phosphorylation	RRSQPQLTQMSVPLV HCCCCCCCCCCHHHH	19.58	23186163
546	Ubiquitination	PLVHQVKKAAPLIVE HHHHHHHHHHHHHHH	51.42	-
546	Sumoylation	PLVHQVKKAAPLIVE HHHHHHHHHHHHHHH	51.42	28112733
561	Phosphorylation	VFNKVLHSSNPVPLY HHHHHHHHCCCCCCC	27.87	24732914
562	Phosphorylation	FNKVLHSSNPVPLYA HHHHHHHCCCCCCCC	34.11	24732914
568	Phosphorylation	SSNPVPLYAPNLSPP HCCCCCCCCCCCCCC	17.59	30266825
573	Phosphorylation	PLYAPNLSPPADSRI CCCCCCCCCCCCCCE	35.16	22167270
578	Phosphorylation	NLSPPADSRIHVPAS CCCCCCCCCEECCCC	34.93	30266825
629	Ubiquitination	KTLLFFNKCSLLRHA HHHHHHHHHHHHHHH	21.75	32015554
649	Phosphorylation	KGLVMQCSQLLVKPI CCHHHHHHHHEEECC	13.63	27080861
657	Phosphorylation	QLLVKPISADQMFVS HHEEECCCCCCEEEE	34.03	26074081
664	Phosphorylation	SADQMFVSAPVNSTA CCCCEEEECCCCCCC	18.65	20873877
669	Phosphorylation	FVSAPVNSTAPAAPA EEECCCCCCCCCCCC	26.61	20873877
670	Phosphorylation	VSAPVNSTAPAAPAP EECCCCCCCCCCCCC	31.30	20873877
678	Phosphorylation	APAAPAPSSSPKHGL CCCCCCCCCCCCCCC	45.62	25159151
679	Phosphorylation	PAAPAPSSSPKHGLT CCCCCCCCCCCCCCC	49.99	25159151
680	Phosphorylation	AAPAPSSSPKHGLTS CCCCCCCCCCCCCCC	42.16	25159151
686	Phosphorylation	SSPKHGLTSGSASPP CCCCCCCCCCCCCCC	35.32	23401153
687	Phosphorylation	SPKHGLTSGSASPPP CCCCCCCCCCCCCCC	35.47	30266825
689	Phosphorylation	KHGLTSGSASPPPPA CCCCCCCCCCCCCCC	25.91	29255136
691	Phosphorylation	GLTSGSASPPPPALP CCCCCCCCCCCCCCC	39.37	29255136
700	Phosphorylation	PPPALPLYPDPVRLI CCCCCCCCCCHHHHH	12.03	30266825
710	Phosphorylation	PVRLIRYSIKCLECH HHHHHHHHHHHHHHH	13.01	24719451
712	Acetylation	RLIRYSIKCLECHKQ HHHHHHHHHHHHHHH	27.16	25953088
766	Phosphorylation	QRIHAHKSPYCCPEC CHHHCCCCCCCCCCC	15.96	25159151
768	Phosphorylation	IHAHKSPYCCPECGV HHCCCCCCCCCCCCC	17.49	28985074
838	Phosphorylation	FCPMAFKTASSTADH CCCCCCCCCCCCCCC	25.89	24043423
840	Phosphorylation	PMAFKTASSTADHSA CCCCCCCCCCCCCCC	33.19	24043423
841	Phosphorylation	MAFKTASSTADHSAT CCCCCCCCCCCCCCC	25.75	24043423
842	Phosphorylation	AFKTASSTADHSATQ CCCCCCCCCCCCCCC	33.34	24043423
846	Phosphorylation	ASSTADHSATQHPTQ CCCCCCCCCCCCCCC	33.29	24043423
848	Phosphorylation	STADHSATQHPTQPH CCCCCCCCCCCCCCC	30.35	24043423
852	Phosphorylation	HSATQHPTQPHRPSQ CCCCCCCCCCCCCHH	53.24	24043423
862	Phosphorylation	HRPSQLIYKCSCEMV CCCHHHHHHEECEEH	17.97	-
865	Phosphorylation	SQLIYKCSCEMVFNK HHHHHHEECEEHHCC	14.68	-
925	Phosphorylation	PRNVDELSSLQSSAD CCCHHHHHHHHHHCC	27.27	28555341
929	Phosphorylation	DELSSLQSSADTSSS HHHHHHHHHCCCCCC	32.55	28555341
933	Phosphorylation	SLQSSADTSSSRPGS HHHHHCCCCCCCCCC	30.17	29978859
934	Phosphorylation	LQSSADTSSSRPGSR HHHHCCCCCCCCCCC	27.19	25852190
935	Phosphorylation	QSSADTSSSRPGSRV HHHCCCCCCCCCCCC	32.24	29978859
936	Phosphorylation	SSADTSSSRPGSRVP HHCCCCCCCCCCCCC	42.11	29978859
955	Phosphorylation	ATSVAARSSSLPSGR CCCHHHHHCCCCCCC	21.39	27251275
956	Phosphorylation	TSVAARSSSLPSGRW CCHHHHHCCCCCCCC	30.27	27251275
957	Phosphorylation	SVAARSSSLPSGRWG CHHHHHCCCCCCCCC	45.61	27251275
1021	Phosphorylation	PCRQCEQSFHTPNSL CCHHHHHHCCCCHHH	9.19	23312004
1024	Phosphorylation	QCEQSFHTPNSLRKH HHHHHCCCCHHHHHH	23.35	25159151
1027	Phosphorylation	QSFHTPNSLRKHIRN HHCCCCHHHHHHHHC	30.65	25159151
1049	Phosphorylation	FYTCGYCTEDSPSFP EEECCCCCCCCCCCC	34.05	25627689
1052	Phosphorylation	CGYCTEDSPSFPRPS CCCCCCCCCCCCCHH	19.06	25627689
1089	Phosphorylation	VKPPGGHSPQVNHLK CCCCCCCCCCCCCCC	21.94	29255136
1100	Phosphorylation	NHLKRPVSGVGDAPG CCCCCCCCCCCCCCC	30.37	28985074
1115	Phosphorylation	TSNGATVSSTKRHKS CCCCCCCCCCCCCCC	28.12	28555341
1116	Phosphorylation	SNGATVSSTKRHKSL CCCCCCCCCCCCCCH	33.34	25627689
1166	Phosphorylation	GLCYTSASSLSRHLF HHHHHCHHHHHHHEE	31.42	26699800
1167	Phosphorylation	LCYTSASSLSRHLFI HHHHCHHHHHHHEEE	30.04	26699800
1205	Phosphorylation	VAEPEEGSGEEVPME HCCCCCCCCCCCCHH	46.43	27422710
1213	Phosphorylation	GEEVPMETRENGLEE CCCCCHHHHHCCCHH	36.71	30108239
1227	Phosphorylation	ECAGEPLSADPEARR HHCCCCCCCCHHHHH	41.14	29978859
1250	Phosphorylation	DGGHNDHSQPQASQD CCCCCCCCCCCHHCC	46.55	17525332
1255	Phosphorylation	DHSQPQASQDQDSHT CCCCCCHHCCCCCCC	29.10	17525332
1260	Phosphorylation	QASQDQDSHTLSPQV CHHCCCCCCCCCCCC	16.85	23401153
1262	Phosphorylation	SQDQDSHTLSPQV-- HCCCCCCCCCCCC--	32.65	23927012
1264	Phosphorylation	DQDSHTLSPQV---- CCCCCCCCCCC----	17.91	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN592_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN592_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN592_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TCAF1_HUMAN	FAM115A	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
606937	Spinocerebellar ataxia, autosomal recessive, 5 (SCAR5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN592_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368; SER-458 ANDSER-459, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-137; SER-145; SER-146;SER-573 AND SER-691, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1250; SER-1255 ANDSER-1264, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142; SER-145; SER-146;SER-331; SER-334 AND SER-1089, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368 AND SER-460, ANDMASS SPECTROMETRY.	15302935 [Abstract]