ABCA7_HUMAN - dbPTM
ABCA7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCA7_HUMAN
UniProt AC Q8IZY2
Protein Name ATP-binding cassette sub-family A member 7
Gene Name ABCA7
Organism Homo sapiens (Human).
Sequence Length 2146
Subcellular Localization Cell membrane
Multi-pass membrane protein . Golgi apparatus membrane
Multi-pass membrane protein . Early endosome membrane
Multi-pass membrane protein . Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q o
Protein Description Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation..
Protein Sequence MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
127UbiquitinationRTLAGLGKLIATLRA
HHHHHHHHHHHHHHH		41.59-
144PhosphorylationSTAQPQPTKQSPLEP
HCCCCCCCCCCCCCC		36.1522985185
147PhosphorylationQPQPTKQSPLEPPML
CCCCCCCCCCCCCCC		32.7746156555
162PhosphorylationDVAELLTSLLRTESL
CHHHHHHHHHHHHHH		25.9424719451
182PhosphorylationQAQEPLHSLLEAAED
CCHHHHHHHHHHHHH		42.1946156559
199PhosphorylationQELLALRSLVELRAL
HHHHHHHHHHHHHHH		37.3023403867
312N-linked_GlycosylationRKLMAQVNRTFEELT
HHHHHHHHCHHHHHH		25.79UniProtKB CARBOHYD
411UbiquitinationTECLSLDKLEAAPSE
HHHCCHHHHHCCCCH		54.22-
450PhosphorylationPEDSSDPTEHPTPDL
CCCCCCCCCCCCCCC		52.4928787133
454PhosphorylationSDPTEHPTPDLGPGH
CCCCCCCCCCCCCCC		31.2028787133
519PhosphorylationRAAVRVLSGANPRAG
HHHHHHHCCCCCCCC		32.7646156563
528PhosphorylationANPRAGLYLQQMPYP
CCCCCCEECCCCCCC		11.1046156575
555O-linked_GlycosylationRSLPLFLTLAWIYSV
HCHHHHHHHHHHHHH		13.7029351928
580PhosphorylationKETRLRDTMRAMGLS
HHHHHHHHHHHCCHH		11.3429116813
794 (in isoform 2)Ubiquitination-9.8421906983
804PhosphorylationEEAPPGLSPGVSVRS
EECCCCCCCCCCHHH		26.0625627689
932 (in isoform 1)Ubiquitination-38.8321906983
932UbiquitinationQDVGLVSKQSVQTRH
HHHCCCCCCCHHHCC		38.832190698
934PhosphorylationVGLVSKQSVQTRHLS
HCCCCCCCHHHCCCC		21.6730622161
937PhosphorylationVSKQSVQTRHLSGGM
CCCCCHHHCCCCHHH		20.2130622161
941PhosphorylationSVQTRHLSGGMQRKL
CHHHCCCCHHHHHHE		27.4630622161
949PhosphorylationGGMQRKLSVAIAFVG
HHHHHHEEEEEEEEC		16.7310411823
958PhosphorylationAIAFVGGSQVVILDE
EEEEECCCEEEEECC		17.5510411833
1033PhosphorylationRRHLGSGYYLTLVKA
HHHCCCCCEEEEEEE		9.3029759185
1034PhosphorylationRHLGSGYYLTLVKAR
HHCCCCCEEEEEEEE		9.2029759185
1041 (in isoform 2)Ubiquitination-30.99-
1175PhosphorylationGIAGLDVTLRLKMPP
CCCCCEEEEEEECCC		13.0624719451
1179UbiquitinationLDVTLRLKMPPQETA
CEEEEEEECCCHHHH		42.82-
1314PhosphorylationEEPPVQHSSHRFSAP
CCCCCCCCCCCCCCC		15.6822210691
1315PhosphorylationEPPVQHSSHRFSAPE
CCCCCCCCCCCCCCC		19.2922210691
1342PhosphorylationNWTPESPSPACQCSR
CCCCCCCCCCCCCCC		34.1123532336
1405PhosphorylationLVRQGLKTKKWVNEV
HHHCCCCCCCCCCCC		42.7946156569
1748PhosphorylationGPLFLLFTLLLQHRS
HHHHHHHHHHHHHHH		19.2350558493
1844PhosphorylationFRMVTGDTLASRGEA
EEECCCCCHHHHCCE		26.1069211681
1905PhosphorylationPEAQVAQTAGSGLAR
CHHHHHHHCCCCCHH		24.2122210691
1908PhosphorylationQVAQTAGSGLARLGL
HHHHHCCCCCHHCCC		28.3329978859
1916PhosphorylationGLARLGLSWYADRPA
CCHHCCCCEECCCCC		19.0822210691
1918PhosphorylationARLGLSWYADRPAGT
HHCCCCEECCCCCCC		8.6829978859
1925PhosphorylationYADRPAGTYSGGNKR
ECCCCCCCCCCCCHH		19.3422210691
2133PhosphorylationLQHPKRVSQFLDDPS
CCCCHHHHHHCCCCC		21.1730266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCA7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCA7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCA7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABCA7_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCA7_HUMAN

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Related Literatures of Post-Translational Modification

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