dbPTM

FIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FIP1_HUMAN
UniProt AC	Q6UN15
Protein Name	Pre-mRNA 3'-end-processing factor FIP1
Gene Name	FIP1L1
Organism	Homo sapiens (Human).
Sequence Length	594
Subcellular Localization	Nucleus.
Protein Description	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex..
Protein Sequence	MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAGEVERL ------CCHHHHHHH	45.01	26852163
11	Phosphorylation	GEVERLVSELSGGTG HHHHHHHHHHHCCCC	37.09	28450419
14	Phosphorylation	ERLVSELSGGTGGDE HHHHHHHHCCCCCCC	30.99	25159151
14 (in isoform 3)	Phosphorylation	-	30.99	25921289
14 (in isoform 4)	Phosphorylation	-	30.99	25921289
14 (in isoform 5)	Phosphorylation	-	30.99	25921289
17	Phosphorylation	VSELSGGTGGDEEEE HHHHHCCCCCCCHHH	41.33	27422710
17 (in isoform 3)	Phosphorylation	-	41.33	25921289
17 (in isoform 4)	Phosphorylation	-	41.33	25921289
17 (in isoform 5)	Phosphorylation	-	41.33	25921289
27	Phosphorylation	DEEEEWLYGGPWDVH CCHHHHHHCCCCCEE	22.55	28450419
37	Phosphorylation	PWDVHVHSDLAKDLD CCCEEECHHHHHCCC	32.98	22617229
57	Phosphorylation	RPEEENASANPPSGI CCHHHCCCCCCCCCC	39.91	25159151
62	Phosphorylation	NASANPPSGIEDETA CCCCCCCCCCCCHHH	54.37	30278072
68	Phosphorylation	PSGIEDETAENGVPK CCCCCCHHHCCCCCC	52.14	30278072
79	Phosphorylation	GVPKPKVTETEDDSD CCCCCCCCCCCCCCC	43.23	28176443
81	Phosphorylation	PKPKVTETEDDSDSD CCCCCCCCCCCCCCC	35.04	28176443
84	Ubiquitination	KVTETEDDSDSDSDD CCCCCCCCCCCCCCC	48.38	32015554
85	Phosphorylation	VTETEDDSDSDSDDD CCCCCCCCCCCCCCC	51.87	26503892
87	Phosphorylation	ETEDDSDSDSDDDED CCCCCCCCCCCCCCC	42.86	26503892
89	Phosphorylation	EDDSDSDSDDDEDDV CCCCCCCCCCCCCCE	47.06	26503892
99	Phosphorylation	DEDDVHVTIGDIKTG CCCCEEEEEEEECCC	12.36	30108239
105	Phosphorylation	VTIGDIKTGAPQYGS EEEEEECCCCCCCCC	38.62	21945579
108	Ubiquitination	GDIKTGAPQYGSYGT EEECCCCCCCCCCCC	29.30	32015554
108 (in isoform 3)	Ubiquitination	-	29.30	21906983
108 (in isoform 4)	Ubiquitination	-	29.30	21906983
110	Phosphorylation	IKTGAPQYGSYGTAP ECCCCCCCCCCCCCC	13.64	21945579
112	Phosphorylation	TGAPQYGSYGTAPVN CCCCCCCCCCCCCCE	18.56	21945579
113	Phosphorylation	GAPQYGSYGTAPVNL CCCCCCCCCCCCCEE	17.71	21945579
115	Phosphorylation	PQYGSYGTAPVNLNI CCCCCCCCCCCEEEE	21.39	21945579
120	Ubiquitination	YGTAPVNLNIKTGGR CCCCCCEEEEECCCE	7.74	27667366
123	Sumoylation	APVNLNIKTGGRVYG CCCEEEEECCCEEEC	39.79	-
123	Sumoylation	APVNLNIKTGGRVYG CCCEEEEECCCEEEC	39.79	-
123	Ubiquitination	APVNLNIKTGGRVYG CCCEEEEECCCEEEC	39.79	29967540
123 (in isoform 1)	Ubiquitination	-	39.79	21906983
124	Phosphorylation	PVNLNIKTGGRVYGT CCEEEEECCCEEECC	40.86	28555341
129	Phosphorylation	IKTGGRVYGTTGTKV EECCCEEECCCCCEE	13.85	-
135	Acetylation	VYGTTGTKVKGVDLD EECCCCCEEECCCCC	43.21	25953088
135	Ubiquitination	VYGTTGTKVKGVDLD EECCCCCEEECCCCC	43.21	27667366
146	Phosphorylation	VDLDAPGSINGVPLL CCCCCCCCCCCEEEE	16.30	28102081
152	Ubiquitination	GSINGVPLLEVDLDS CCCCCEEEEEEEHHH	6.22	29967540
167	Ubiquitination	FEDKPWRKPGADLSD CCCCCCCCCCCCHHH	43.89	29967540
173	Ubiquitination	RKPGADLSDYFNYGF CCCCCCHHHHHCCCC	30.71	32015554
175	Phosphorylation	PGADLSDYFNYGFNE CCCCHHHHHCCCCCH	7.14	-
178	Phosphorylation	DLSDYFNYGFNEDTW CHHHHHCCCCCHHHH	17.13	-
186	Acetylation	GFNEDTWKAYCEKQK CCCHHHHHHHHHHHH	31.41	26051181
195	Ubiquitination	YCEKQKRIRMGLEVI HHHHHHCCCCCCEEE	4.60	32015554
195 (in isoform 3)	Ubiquitination	-	4.60	-
196	Ubiquitination	CEKQKRIRMGLEVIP HHHHHCCCCCCEEEE	19.70	32015554
197	Sulfoxidation	EKQKRIRMGLEVIPV HHHHCCCCCCEEEEC	7.17	21406390
205	O-linked_Glycosylation	GLEVIPVTSTTNKIT CCEEEECCCCCCCEE	18.27	20068230
205	Phosphorylation	GLEVIPVTSTTNKIT CCEEEECCCCCCCEE	18.27	26074081
206	O-linked_Glycosylation	LEVIPVTSTTNKITA CEEEECCCCCCCEEH	33.21	20068230
206	Phosphorylation	LEVIPVTSTTNKITA CEEEECCCCCCCEEH	33.21	26074081
207	O-linked_Glycosylation	EVIPVTSTTNKITAE EEEECCCCCCCEEHH	25.64	20068230
207	Phosphorylation	EVIPVTSTTNKITAE EEEECCCCCCCEEHH	25.64	26074081
208	O-linked_Glycosylation	VIPVTSTTNKITAED EEECCCCCCCEEHHH	33.99	20068230
208	Phosphorylation	VIPVTSTTNKITAED EEECCCCCCCEEHHH	33.99	26074081
208	Ubiquitination	VIPVTSTTNKITAED EEECCCCCCCEEHHH	33.99	27667366
212	Phosphorylation	TSTTNKITAEDCTME CCCCCCEEHHHCCEE	26.13	20873877
214	Ubiquitination	TTNKITAEDCTMEVT CCCCEEHHHCCEEEC	44.99	32015554
215	Ubiquitination	TNKITAEDCTMEVTP CCCEEHHHCCEEECC	30.62	32015554
216	Ubiquitination	NKITAEDCTMEVTPG CCEEHHHCCEEECCC	2.69	32015554
217	Phosphorylation	KITAEDCTMEVTPGA CEEHHHCCEEECCCC	28.78	29978859
220	Ubiquitination	AEDCTMEVTPGAEIQ HHHCCEEECCCCEEE	5.63	32015554
221	Phosphorylation	EDCTMEVTPGAEIQD HHCCEEECCCCEEEC	11.60	25159151
221 (in isoform 3)	Phosphorylation	-	11.60	25159151
223	Ubiquitination	CTMEVTPGAEIQDGR CCEEECCCCEEECCC	26.86	27667366
224 (in isoform 3)	Phosphorylation	-	16.36	25159151
229	Ubiquitination	PGAEIQDGRFNLFKV CCCEEECCCEEEEEE	21.50	32015554
230	Ubiquitination	GAEIQDGRFNLFKVQ CCEEECCCEEEEEEE	26.10	32015554
231	Ubiquitination	AEIQDGRFNLFKVQQ CEEECCCEEEEEEEC	13.09	27667366
235	Ubiquitination	DGRFNLFKVQQGRTG CCCEEEEEEECCCCC	42.15	32015554
239	Ubiquitination	NLFKVQQGRTGNSEK EEEEEECCCCCCCCC	16.42	32015554
241	O-linked_Glycosylation	FKVQQGRTGNSEKET EEEECCCCCCCCCCC	47.76	20068230
241	Phosphorylation	FKVQQGRTGNSEKET EEEECCCCCCCCCCC	47.76	24732914
244	Phosphorylation	QQGRTGNSEKETALP ECCCCCCCCCCCCCC	51.93	24732914
246	Acetylation	GRTGNSEKETALPST CCCCCCCCCCCCCCC	61.25	25953088
246	Ubiquitination	GRTGNSEKETALPST CCCCCCCCCCCCCCC	61.25	27667366
248	O-linked_Glycosylation	TGNSEKETALPSTKA CCCCCCCCCCCCCCE	44.56	20068230
248	Phosphorylation	TGNSEKETALPSTKA CCCCCCCCCCCCCCE	44.56	24732914
252	O-linked_Glycosylation	EKETALPSTKAEFTS CCCCCCCCCCEECCC	43.31	20068230
252	Phosphorylation	EKETALPSTKAEFTS CCCCCCCCCCEECCC	43.31	24732914
252	Ubiquitination	EKETALPSTKAEFTS CCCCCCCCCCEECCC	43.31	32015554
253	O-linked_Glycosylation	KETALPSTKAEFTSP CCCCCCCCCEECCCC	32.13	30059200
253	O-linked_Glycosylation	KETALPSTKAEFTSP CCCCCCCCCEECCCC	32.13	20068230
253	Phosphorylation	KETALPSTKAEFTSP CCCCCCCCCEECCCC	32.13	24732914
254	Sumoylation	ETALPSTKAEFTSPP CCCCCCCCEECCCCC	50.70	-
254	Sumoylation	ETALPSTKAEFTSPP CCCCCCCCEECCCCC	50.70	-
254	Ubiquitination	ETALPSTKAEFTSPP CCCCCCCCEECCCCC	50.70	32015554
258	O-linked_Glycosylation	PSTKAEFTSPPSLFK CCCCEECCCCCHHHC	31.65	20068230
258	Phosphorylation	PSTKAEFTSPPSLFK CCCCEECCCCCHHHC	31.65	29255136
259	O-linked_Glycosylation	STKAEFTSPPSLFKT CCCEECCCCCHHHCC	39.88	20068230
259	Phosphorylation	STKAEFTSPPSLFKT CCCEECCCCCHHHCC	39.88	19664994
262	Phosphorylation	AEFTSPPSLFKTGLP EECCCCCHHHCCCCC	50.23	29255136
265	Methylation	TSPPSLFKTGLPPSR CCCCHHHCCCCCCCC	47.15	-
274	Phosphorylation	GLPPSRNSTSSQSQT CCCCCCCCCCCCCHH	28.67	30576142
275	O-linked_Glycosylation	LPPSRNSTSSQSQTS CCCCCCCCCCCCHHH	35.63	20068230
275	Phosphorylation	LPPSRNSTSSQSQTS CCCCCCCCCCCCHHH	35.63	26434776
276	O-linked_Glycosylation	PPSRNSTSSQSQTST CCCCCCCCCCCHHHH	26.63	20068230
276	Phosphorylation	PPSRNSTSSQSQTST CCCCCCCCCCCHHHH	26.63	26074081
277	Phosphorylation	PSRNSTSSQSQTSTA CCCCCCCCCCHHHHH	33.66	26074081
279	Acetylation	RNSTSSQSQTSTASR CCCCCCCCHHHHHHH	37.06	19608861
279	Phosphorylation	RNSTSSQSQTSTASR CCCCCCCCHHHHHHH	37.06	26074081
281	Phosphorylation	STSSQSQTSTASRKA CCCCCCHHHHHHHHH	33.04	26074081
282	Phosphorylation	TSSQSQTSTASRKAN CCCCCHHHHHHHHHH	17.84	26074081
283	Phosphorylation	SSQSQTSTASRKANS CCCCHHHHHHHHHHC	31.85	26074081
287	Acetylation	QTSTASRKANSSVGK HHHHHHHHHHCHHCH	49.80	25953088
290	Phosphorylation	TASRKANSSVGKWQD HHHHHHHCHHCHHHH	31.12	22210691
291	Phosphorylation	ASRKANSSVGKWQDR HHHHHHCHHCHHHHH	34.40	22210691
294	Acetylation	KANSSVGKWQDRYGR HHHCHHCHHHHHCCC	39.25	19608861
294	Ubiquitination	KANSSVGKWQDRYGR HHHCHHCHHHHHCCC	39.25	19608861
299	Phosphorylation	VGKWQDRYGRAESPD HCHHHHHCCCCCCCC	21.18	23403867
304	Phosphorylation	DRYGRAESPDLRRLP HHCCCCCCCCHHHCC	23.80	29255136
320	Phosphorylation	AIDVIGQTITISRVE CEEECCCEEEEEEEC	18.18	25332170
322	Phosphorylation	DVIGQTITISRVEGR EECCCEEEEEEECCC	19.11	28555341
324	Phosphorylation	IGQTITISRVEGRRR CCCEEEEEEECCCHH	22.94	24719451
336	Phosphorylation	RRRANENSNIQVLSE CHHCCCCCCEEEEEC	29.18	28555341
345	O-linked_Glycosylation	IQVLSERSATEVDNN EEEEECCCCCCCCCC	35.18	20068230
347	O-linked_Glycosylation	VLSERSATEVDNNFS EEECCCCCCCCCCCC	37.48	20068230
367	O-linked_Glycosylation	FPPGAPPTHLPPPPF CCCCCCCCCCCCCCC	34.68	20068230
375	Ubiquitination	HLPPPPFLPPPPTVS CCCCCCCCCCCCCCC	8.41	23503661
375 (in isoform 3)	Ubiquitination	-	8.41	-
382	O-linked_Glycosylation	LPPPPTVSTAPPLIP CCCCCCCCCCCCCCC	22.72	20068230
384	Ubiquitination	PPPTVSTAPPLIPPP CCCCCCCCCCCCCCC	9.01	23503661
390	Ubiquitination	TAPPLIPPPGFPPPP CCCCCCCCCCCCCCC	34.35	23503661
398	Ubiquitination	PGFPPPPGAPPPSLI CCCCCCCCCCCCCCC	57.39	23503661
399	Ubiquitination	GFPPPPGAPPPSLIP CCCCCCCCCCCCCCC	21.14	23503661
403	O-linked_Glycosylation	PPGAPPPSLIPTIES CCCCCCCCCCCCCCC	44.71	20068230
407	Ubiquitination	PPPSLIPTIESGHSS CCCCCCCCCCCCCCC	30.31	23503661
411	Phosphorylation	LIPTIESGHSSGYDS CCCCCCCCCCCCCCC	16.35	32142685
411	Ubiquitination	LIPTIESGHSSGYDS CCCCCCCCCCCCCCC	16.35	23503661
413	Phosphorylation	PTIESGHSSGYDSRS CCCCCCCCCCCCCCC	29.05	33259812
413	Ubiquitination	PTIESGHSSGYDSRS CCCCCCCCCCCCCCC	29.05	23503661
416	Phosphorylation	ESGHSSGYDSRSARA CCCCCCCCCCCCCCC	16.82	32142685
417	Phosphorylation	SGHSSGYDSRSARAF CCCCCCCCCCCCCCC	40.89	32142685
418	Phosphorylation	GHSSGYDSRSARAFP CCCCCCCCCCCCCCC	21.46	33259812
419	Phosphorylation	HSSGYDSRSARAFPY CCCCCCCCCCCCCCC	31.29	32645325
420	Phosphorylation	SSGYDSRSARAFPYG CCCCCCCCCCCCCCC	26.51	33259812
420	Ubiquitination	SSGYDSRSARAFPYG CCCCCCCCCCCCCCC	26.51	23503661
422	Ubiquitination	GYDSRSARAFPYGNV CCCCCCCCCCCCCCE	37.70	23503661
424	Phosphorylation	DSRSARAFPYGNVAF CCCCCCCCCCCCEEC	3.89	32645325
425	Phosphorylation	SRSARAFPYGNVAFP CCCCCCCCCCCEECC	34.83	32645325
426	Phosphorylation	RSARAFPYGNVAFPH CCCCCCCCCCEECCC	18.19	28796482
426	Ubiquitination	RSARAFPYGNVAFPH CCCCCCCCCCEECCC	18.19	23503661
427	Phosphorylation	SARAFPYGNVAFPHL CCCCCCCCCEECCCC	23.52	32142685
429	Phosphorylation	RAFPYGNVAFPHLPG CCCCCCCEECCCCCC	5.15	33259812
431	Phosphorylation	FPYGNVAFPHLPGSA CCCCCEECCCCCCCC	3.22	32142685
433	Phosphorylation	YGNVAFPHLPGSAPS CCCEECCCCCCCCCC	37.90	32142685
434	Ubiquitination	GNVAFPHLPGSAPSW CCEECCCCCCCCCCC	5.38	23503661
435	Phosphorylation	NVAFPHLPGSAPSWP CEECCCCCCCCCCCH	31.49	32645325
435	Ubiquitination	NVAFPHLPGSAPSWP CEECCCCCCCCCCCH	31.49	23503661
437	Phosphorylation	AFPHLPGSAPSWPSL ECCCCCCCCCCCHHH	34.76	28442448
439	Phosphorylation	PHLPGSAPSWPSLVD CCCCCCCCCCHHHCC	38.33	32645325
440	Phosphorylation	HLPGSAPSWPSLVDT CCCCCCCCCHHHCCC	51.87	29978859
441	Phosphorylation	LPGSAPSWPSLVDTS CCCCCCCCHHHCCCH	5.85	32645325
442	Phosphorylation	PGSAPSWPSLVDTSK CCCCCCCHHHCCCHH	23.32	32142685
443	Phosphorylation	GSAPSWPSLVDTSKQ CCCCCCHHHCCCHHH	34.46	33259812
443	Ubiquitination	GSAPSWPSLVDTSKQ CCCCCCHHHCCCHHH	34.46	23503661
444	Phosphorylation	SAPSWPSLVDTSKQW CCCCCHHHCCCHHHH	3.38	33259812
447	Phosphorylation	SWPSLVDTSKQWDYY CCHHHCCCHHHHHHH	30.28	29978859
448	Phosphorylation	WPSLVDTSKQWDYYA CHHHCCCHHHHHHHH	20.56	29978859
449	Phosphorylation	PSLVDTSKQWDYYAR HHHCCCHHHHHHHHH	58.46	32645325
449	Ubiquitination	PSLVDTSKQWDYYAR HHHCCCHHHHHHHHH	58.46	23503661
450	Phosphorylation	SLVDTSKQWDYYARR HHCCCHHHHHHHHHH	37.73	32645325
452	Phosphorylation	VDTSKQWDYYARREK CCCHHHHHHHHHHHH	24.87	32142685
453	Phosphorylation	DTSKQWDYYARREKD CCHHHHHHHHHHHHH	8.96	28796482
454	Phosphorylation	TSKQWDYYARREKDR CHHHHHHHHHHHHHH	7.37	28796482
456	Phosphorylation	KQWDYYARREKDRDR HHHHHHHHHHHHHHH	31.04	32142685
458	Phosphorylation	WDYYARREKDRDRER HHHHHHHHHHHHHHH	54.47	32645325
458	Ubiquitination	WDYYARREKDRDRER HHHHHHHHHHHHHHH	54.47	23503661
460	Phosphorylation	YYARREKDRDRERDR HHHHHHHHHHHHHHH	53.62	32645325
461	Phosphorylation	YARREKDRDRERDRD HHHHHHHHHHHHHHH	56.82	32142685
462	Phosphorylation	ARREKDRDRERDRDR HHHHHHHHHHHHHHH	67.91	32645325
463	Phosphorylation	RREKDRDRERDRDRE HHHHHHHHHHHHHHH	41.57	32142685
464	Phosphorylation	REKDRDRERDRDRER HHHHHHHHHHHHHHH	64.32	32645325
465	Phosphorylation	EKDRDRERDRDRERD HHHHHHHHHHHHHHH	45.20	32142685
467	Phosphorylation	DRDRERDRDRERDRD HHHHHHHHHHHHHHH	51.62	33259812
468	Phosphorylation	RDRERDRDRERDRDR HHHHHHHHHHHHHHH	62.17	32142685
469	Phosphorylation	DRERDRDRERDRDRD HHHHHHHHHHHHHHH	41.57	32645325
470	Phosphorylation	RERDRDRERDRDRDR HHHHHHHHHHHHHHH	64.32	33259812
471	Phosphorylation	ERDRDRERDRDRDRE HHHHHHHHHHHHHHH	45.20	32645325
473	Phosphorylation	DRDRERDRDRDRERE HHHHHHHHHHHHHHH	47.27	32645325
476	Phosphorylation	RERDRDRDRERERTR HHHHHHHHHHHHHHH	62.17	32645325
477	Phosphorylation	ERDRDRDRERERTRE HHHHHHHHHHHHHHH	45.85	32645325
478	Phosphorylation	RDRDRDRERERTRER HHHHHHHHHHHHHHH	64.28	32142685
479	Phosphorylation	DRDRDRERERTRERE HHHHHHHHHHHHHHH	39.32	33259812
480	Phosphorylation	RDRDRERERTRERER HHHHHHHHHHHHHHH	54.36	33259812
482	Phosphorylation	RDRERERTRERERER HHHHHHHHHHHHHHH	31.93	20068231
484	Phosphorylation	RERERTRERERERDH HHHHHHHHHHHHHCC	59.28	32645325
485	Phosphorylation	ERERTRERERERDHS HHHHHHHHHHHHCCC	45.01	32645325
486	Phosphorylation	RERTRERERERDHSP HHHHHHHHHHHCCCC	54.89	32645325
488	Phosphorylation	RTRERERERDHSPTP HHHHHHHHHCCCCCC	58.68	33259812
492	Phosphorylation	RERERDHSPTPSVFN HHHHHCCCCCCCCCC	34.46	19664994
494	Phosphorylation	RERDHSPTPSVFNSD HHHCCCCCCCCCCCH	31.07	29255136
496	Phosphorylation	RDHSPTPSVFNSDEE HCCCCCCCCCCCHHH	41.65	29255136
499	Phosphorylation	SPTPSVFNSDEERYR CCCCCCCCCHHHHHH	46.53	32142685
500	Phosphorylation	PTPSVFNSDEERYRY CCCCCCCCHHHHHHH	34.63	19664994
501	Phosphorylation	TPSVFNSDEERYRYR CCCCCCCHHHHHHHH	63.98	32142685
501	Ubiquitination	TPSVFNSDEERYRYR CCCCCCCHHHHHHHH	63.98	24816145
503	Phosphorylation	SVFNSDEERYRYREY CCCCCHHHHHHHHHH	61.06	33259812
505	Phosphorylation	FNSDEERYRYREYAE CCCHHHHHHHHHHHH	18.44	23927012
507	Phosphorylation	SDEERYRYREYAERG CHHHHHHHHHHHHHH	10.00	26074081
509	Phosphorylation	EERYRYREYAERGYE HHHHHHHHHHHHHHH	39.91	32645325
510	Phosphorylation	ERYRYREYAERGYER HHHHHHHHHHHHHHH	12.55	26074081
510	Ubiquitination	ERYRYREYAERGYER HHHHHHHHHHHHHHH	12.55	24816145
513	Methylation	RYREYAERGYERHRA HHHHHHHHHHHHHHH	44.84	-
515	Phosphorylation	REYAERGYERHRASR HHHHHHHHHHHHHHH	18.93	22817900
516	Ubiquitination	EYAERGYERHRASRE HHHHHHHHHHHHHHH	44.85	24816145
521	Phosphorylation	GYERHRASREKEERH HHHHHHHHHHHHHHH	40.71	23312004
524	Ubiquitination	RHRASREKEERHRER HHHHHHHHHHHHHHH	64.86	24816145
525	Ubiquitination	HRASREKEERHRERR HHHHHHHHHHHHHHH	56.35	24816145
533	Ubiquitination	ERHRERRHREKEETR HHHHHHHHHHHHHHH	48.77	24816145
537	Ubiquitination	ERRHREKEETRHKSS HHHHHHHHHHHHHHH	60.90	24816145
539	Ubiquitination	RHREKEETRHKSSRS HHHHHHHHHHHHHHC	38.88	24816145
546	Ubiquitination	TRHKSSRSNSRRRHE HHHHHHHCHHHHHHH	40.90	24816145
548	Phosphorylation	HKSSRSNSRRRHESE HHHHHCHHHHHHHCC	28.54	17081983
548	Ubiquitination	HKSSRSNSRRRHESE HHHHHCHHHHHHHCC	28.54	24816145
552	Ubiquitination	RSNSRRRHESEEGDS HCHHHHHHHCCCCHH	40.91	24816145
554	Phosphorylation	NSRRRHESEEGDSHR HHHHHHHCCCCHHHH	34.52	27273156
559	Phosphorylation	HESEEGDSHRRHKHK HHCCCCHHHHHHHCH	29.74	28176443
560	Ubiquitination	ESEEGDSHRRHKHKK HCCCCHHHHHHHCHH	35.22	24816145
561	Ubiquitination	SEEGDSHRRHKHKKS CCCCHHHHHHHCHHH	46.48	24816145
569	Ubiquitination	RHKHKKSKRSKEGKE HHHCHHHHHHHHHHH	70.35	24816145
571	Phosphorylation	KHKKSKRSKEGKEAG HCHHHHHHHHHHHCC	38.50	21712546
575	Ubiquitination	SKRSKEGKEAGSEPA HHHHHHHHHCCCCCC	45.54	24816145
579	Phosphorylation	KEGKEAGSEPAPEQE HHHHHCCCCCCCCCC	47.67	25159151
584	Ubiquitination	AGSEPAPEQESTEAT CCCCCCCCCCCCCCC	69.92	24816145
587	Phosphorylation	EPAPEQESTEATPAE CCCCCCCCCCCCCCC	31.10	20068231
588	Phosphorylation	PAPEQESTEATPAE- CCCCCCCCCCCCCC-	28.96	30576142
591	Phosphorylation	EQESTEATPAE---- CCCCCCCCCCC----	19.46	28655764

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
110	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WDR33_HUMAN	WDR33	physical	22939629
NU153_HUMAN	NUP153	physical	22939629
ANM2_HUMAN	PRMT2	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
ZMY19_HUMAN	ZMYND19	physical	25416956
CPSF1_HUMAN	CPSF1	physical	26344197
PCF11_HUMAN	PCF11	physical	26344197
CPSF1_HUMAN	CPSF1	physical	14749727
CPSF2_HUMAN	CPSF2	physical	14749727
CPSF3_HUMAN	CPSF3	physical	14749727
CSTFT_HUMAN	CSTF2T	physical	14749727
PAPOA_HUMAN	PAPOLA	physical	14749727
CPSF4_HUMAN	CPSF4	physical	14749727
CSTF3_HUMAN	CSTF3	physical	14749727
CSTF1_HUMAN	CSTF1	physical	26496610
CSTF2_HUMAN	CSTF2	physical	26496610
CSTF3_HUMAN	CSTF3	physical	26496610
ERG7_HUMAN	LSS	physical	26496610
P4HA1_HUMAN	P4HA1	physical	26496610
PDIA1_HUMAN	P4HB	physical	26496610
PML_HUMAN	PML	physical	26496610
SYMPK_HUMAN	SYMPK	physical	26496610
P4HA2_HUMAN	P4HA2	physical	26496610
CRTAP_HUMAN	CRTAP	physical	26496610
CPSF4_HUMAN	CPSF4	physical	26496610
WWP2_HUMAN	WWP2	physical	26496610
CSTFT_HUMAN	CSTF2T	physical	26496610
CPSF1_HUMAN	CPSF1	physical	26496610
CPSF3_HUMAN	CPSF3	physical	26496610
CPSF2_HUMAN	CPSF2	physical	26496610
WDR33_HUMAN	WDR33	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FIP1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-294, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-87; SER-89;SER-259; SER-492; THR-494; SER-496 AND SER-500, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-258; SER-259; SER-492;SER-500 AND SER-579, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81; SER-85; SER-87;SER-89; SER-259; SER-304; SER-492; SER-496 AND SER-500, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-87; SER-89;SER-259 AND SER-492, AND MASS SPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-87; SER-89;SER-304; SER-492; SER-500 AND SER-554, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259, AND MASSSPECTROMETRY.	15302935 [Abstract]