BHE41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BHE41_HUMAN
• UniProt AC: Q9C0J9
• Protein Name: Class E basic helix-loop-helix protein 41
• Gene Name: BHLHE41
• Organism: Homo sapiens (Human).
• Sequence Length: 482
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity..
• Protein Sequence: MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLSPPPEKAGAAAATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKEAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Sumoylation	YSSLYMCKPKRSMKR HHHEEEECCCCCCCC	36.72	28112733
42	Acetylation	SMKRDDTKDTYKLPH CCCCCCCCCCHHHHH	55.88	11794097
46	Acetylation	DDTKDTYKLPHRLIE CCCCCCHHHHHHHHH	58.60	11794109
76	Ubiquitination	DLLPEHLKLTTLGHL HHCHHHHHCCCHHHH	45.77	-
119	Phosphorylation	ALQNGERSLKSPIQS CCCCCCCCCCCCCHH	35.53	30108239
121	Sumoylation	QNGERSLKSPIQSDL CCCCCCCCCCCHHHH	56.27	28112733
122	Phosphorylation	NGERSLKSPIQSDLD CCCCCCCCCCHHHHH	32.31	26657352
126	Phosphorylation	SLKSPIQSDLDAFHS CCCCCCHHHHHHHHH	40.64	30108239
151	Phosphorylation	QYLSRFESWTPREPR HHHHCCCCCCCCCHH	33.27	-
210	Sumoylation	CLERAGQKLEPLAYC HHHHCCCCCCCHHHH	54.63	-
210	Sumoylation	CLERAGQKLEPLAYC HHHHCCCCCCCHHHH	54.63	28112733
236	Phosphorylation	ELAAENDTDTDSGYG HHHHCCCCCCCCCCC	52.99	24719451
266	Sumoylation	GASRVTIKQEPPGED CCCCEEEECCCCCCC	38.96	-
266	Sumoylation	GASRVTIKQEPPGED CCCCEEEECCCCCCC	38.96	28112733
274	Phosphorylation	QEPPGEDSPAPKRMK CCCCCCCCCCCCCCC	20.75	28857561
389	Phosphorylation	AAPFPLLYPGIPAPA CCCCCCCCCCCCHHH	13.70	27251275
416	Phosphorylation	AAAFPCLSSVLSPPP HHHCHHHHHHCCCCH	25.72	27251275
417	Phosphorylation	AAFPCLSSVLSPPPE HHCHHHHHHCCCCHH	17.71	27251275
420	Phosphorylation	PCLSSVLSPPPEKAG HHHHHHCCCCHHHCC	32.95	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BHE41_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BHE41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BHE41_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEBPB_HUMAN	CEBPB	physical	19029947
BHE41_HUMAN	BHLHE41	physical	17487425
MYOD1_HUMAN	MYOD1	physical	17487425
HDAC1_HUMAN	HDAC1	physical	20821348
BHE40_HUMAN	BHLHE40	physical	15560782
HIF1A_HUMAN	HIF1A	physical	22801492
PSA4_HUMAN	PSMA4	physical	22801492
BHE41_HUMAN	BHLHE41	physical	22801492
CEBPA_HUMAN	CEBPA	physical	22355045
HDAC1_HUMAN	HDAC1	physical	22355045
FBW1B_HUMAN	FBXW11	physical	23555304
GSK3B_HUMAN	GSK3B	physical	23555304
NONO_HUMAN	NONO	physical	23555304
2A5E_HUMAN	PPP2R5E	physical	23555304
RORG_HUMAN	RORC	physical	23555304
BHE41_HUMAN	BHLHE41	physical	23555304
WDR5_HUMAN	WDR5	physical	23555304
PER2_HUMAN	PER2	physical	23555304
2AAB_HUMAN	PPP2R1B	physical	23555304
RASD1_HUMAN	RASD1	physical	23555304
PP2AB_HUMAN	PPP2CB	physical	23555304
RORA_HUMAN	RORA	physical	23555304

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.