RORG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RORG_HUMAN
• UniProt AC: P51449
• Protein Name: Nuclear receptor ROR-gamma
• Gene Name: RORC
• Organism: Homo sapiens (Human).
• Sequence Length: 518
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. [PubMed: 19381306]
• Protein Sequence: MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	AAKKTHTSQIEVIPC HHHHCCCCCCEEEEE	22.89	30631047
37	Acetylation	PCKICGDKSSGIHYG EEEECCCCCCCCEEE	31.63	30591995
58	Phosphorylation	CKGFFRRSQRCNAAY CCHHHHHHHHCCCHH	20.09	26074081
65	Phosphorylation	SQRCNAAYSCTRQQN HHHCCCHHHCCCCCC	11.23	26074081
66	Phosphorylation	QRCNAAYSCTRQQNC HHCCCHHHCCCCCCC	12.32	26074081
68	Phosphorylation	CNAAYSCTRQQNCPI CCCHHHCCCCCCCCC	26.10	26074081
78	Phosphorylation	QNCPIDRTSRNRCQH CCCCCCCCCCCCHHH	28.43	26074081
79	Phosphorylation	NCPIDRTSRNRCQHC CCCCCCCCCCCHHHH	28.58	26074081
102	Ubiquitination	GMSRDAVKFGRMSKK CCCHHHHHHCCCCHH	43.77	-
205	Phosphorylation	ASCHLEYSPERGKAE CCCEEEECCCCCCCC	15.77	23898821
219	Phosphorylation	EGRESFYSTGSQLTP CCCCCCCCCCCCCCC	25.04	26074081
220	Phosphorylation	GRESFYSTGSQLTPD CCCCCCCCCCCCCCC	29.49	26074081
222	Phosphorylation	ESFYSTGSQLTPDRC CCCCCCCCCCCCCCC	23.31	26074081
225	Phosphorylation	YSTGSQLTPDRCGLR CCCCCCCCCCCCCCC	18.59	26074081
253	Phosphorylation	QGPDSYGSPSFRSTP CCCCCCCCCCCCCCC	14.78	24719451
264	Phosphorylation	RSTPEAPYASLTEIE CCCCCCCCCCHHHHH	18.83	20736484
276	Phosphorylation	EIEHLVQSVCKSYRE HHHHHHHHHHHHHHH	23.23	-
279	Ubiquitination	HLVQSVCKSYRETCQ HHHHHHHHHHHHHHH	48.65	-
339	Phosphorylation	VEFAKRLSGFMELCQ HHHHHHHHHHHHHHC	33.74	-
510	Phosphorylation	KELFSTETESPVGLS HHHHCCCCCCCCCCC	41.68	28348404
512	Phosphorylation	LFSTETESPVGLSK- HHCCCCCCCCCCCC-	32.10	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RORG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RORG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RORG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLOCK_HUMAN	CLOCK	physical	23555304
BMAL1_HUMAN	ARNTL	physical	23555304
TRAF5_HUMAN	TRAF5	physical	26453305
HDAC1_HUMAN	HDAC1	physical	26549310
SRC_HUMAN	SRC	physical	27430721
UBP15_HUMAN	USP15	physical	27430721
SG1D2_HUMAN	SCGB1D2	physical	28514442
PPGB_HUMAN	CTSA	physical	28514442
P53_HUMAN	TP53	physical	28514442
BGAL_HUMAN	GLB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.