RASD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RASD1_HUMAN
• UniProt AC: Q9Y272
• Protein Name: Dexamethasone-induced Ras-related protein 1
• Gene Name: RASD1
• Organism: Homo sapiens (Human).
• Sequence Length: 281
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, perinuclear region. Nucleus.
• Protein Description: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity)..
• Protein Sequence: MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLRQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVDQREIEQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGGDPGDAFGIVAPFARRPSVHSDLMYIREKASAGSQAKDKERCVIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	S-nitrosylation	AAMIKKMCPSDSELS HHHHHHHCCCCCCCC	3.91	12498886
11	S-nitrosocysteine	AAMIKKMCPSDSELS HHHHHHHCCCCCCCC	3.91	-
13	Phosphorylation	MIKKMCPSDSELSIP HHHHHCCCCCCCCCC	49.17	30631047
15	Phosphorylation	KKMCPSDSELSIPAK HHHCCCCCCCCCCCC	44.78	30631047
32	Phosphorylation	YRMVILGSSKVGKTA EEEEEECCCCCCCHH	24.44	30631047
33	Phosphorylation	RMVILGSSKVGKTAI EEEEECCCCCCCHHH	29.57	30631047
66	Phosphorylation	DFHRKFYSIRGEVYQ HHHHHHHCCCCEEEE	14.67	24719451
92 (in isoform 2)	Phosphorylation	-	17.46	30631047
124	Phosphorylation	LRQQILDTKSCLKNK HHHHHHCCHHHHCCC	22.78	24702127
182	Phosphorylation	EISAKKNSSLDQMFR EEECCCCCCHHHHHH	40.95	29978859
183	Phosphorylation	ISAKKNSSLDQMFRA EECCCCCCHHHHHHH	45.41	29978859
199	Phosphorylation	FAMAKLPSEMSPDLH HHHHCCCHHCCHHHH	57.26	29978859
202	Phosphorylation	AKLPSEMSPDLHRKV HCCCHHCCHHHHHHH	15.94	29978859
210	Phosphorylation	PDLHRKVSVQYCDVL HHHHHHHHHHHHHHH	13.41	24719451
219	Ubiquitination	QYCDVLHKKALRNKK HHHHHHCHHHHHCCC	35.26	32142685
232	Phosphorylation	KKLLRAGSGGGGGDP CCCCCCCCCCCCCCH	33.02	28355574
254	Phosphorylation	APFARRPSVHSDLMY CCCCCCCCCCCCHHH	30.56	29978859
257	Phosphorylation	ARRPSVHSDLMYIRE CCCCCCCCCHHHHHH	30.22	29978859
261	Phosphorylation	SVHSDLMYIREKASA CCCCCHHHHHHHHHC	12.25	29978859
267	Phosphorylation	MYIREKASAGSQAKD HHHHHHHHCCCCCCC	44.20	29083192
270	Phosphorylation	REKASAGSQAKDKER HHHHHCCCCCCCCCC	27.04	29083192
273	Ubiquitination	ASAGSQAKDKERCVI HHCCCCCCCCCCCCC	62.79	30230243
278	Methylation	QAKDKERCVIS---- CCCCCCCCCCC----	3.14	-
278	Farnesylation	QAKDKERCVIS---- CCCCCCCCCCC----	3.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RASD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RASD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RASD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAPON_HUMAN	NOS1AP	physical	11086993
NOS1_HUMAN	NOS1	physical	11086993
GNAI1_HUMAN	GNAI1	physical	10840027
GBB1_HUMAN	GNB1	physical	16225846
RBY1F_HUMAN	RBMY1F	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

S-nitrosylation

"Nitrosopeptide mapping: a novel methodology reveals s-nitrosylationof dexras1 on a single cysteine residue.";
Jaffrey S.R., Fang M., Snyder S.H.;
Chem. Biol. 9:1329-1335(2002).
Cited for: S-NITROSYLATION AT CYS-11, AND MUTAGENESIS OF CYS-11.
PubMed: 12498886