IMP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMP3_HUMAN
• UniProt AC: Q9NV31
• Protein Name: U3 small nucleolar ribonucleoprotein protein IMP3
• Gene Name: IMP3
• Organism: Homo sapiens (Human).
• Sequence Length: 184
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing..
• Protein Sequence: MVRKLKFHEQKLLKQVDFLNWEVTDHNLHELRVLRRYRLQRREDYTRYNQLSRAVRELARRLRDLPERDQFRVRASAALLDKLYALGLVPTRGSLELCDFVTASSFCRRRLPTVLLKLRMAQHLQAAVAFVEQGHVRVGPDVVTDPAFLVTRSMEDFVTWVDSSKIKRHVLEYNEERDDFDLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	KLKFHEQKLLKQVDF CCHHHHHHHHHHCCC	53.45	29967540
14	Ubiquitination	FHEQKLLKQVDFLNW HHHHHHHHHCCCCCC	59.73	-
82	Ubiquitination	ASAALLDKLYALGLV HHHHHHHHHHHCCCC	43.28	23000965
84	Phosphorylation	AALLDKLYALGLVPT HHHHHHHHHCCCCCC	12.91	22817900
113	Phosphorylation	FCRRRLPTVLLKLRM HHHHHHHHHHHHHHH	28.51	21130716
117	Ubiquitination	RLPTVLLKLRMAQHL HHHHHHHHHHHHHHH	29.86	21963094
153	Phosphorylation	PAFLVTRSMEDFVTW CHHHEECCHHHHHHH	19.70	20068231
159	Phosphorylation	RSMEDFVTWVDSSKI CCHHHHHHHHCHHHH	21.55	20068231
163	Phosphorylation	DFVTWVDSSKIKRHV HHHHHHCHHHHHHHH	24.74	24719451
164	Phosphorylation	FVTWVDSSKIKRHVL HHHHHCHHHHHHHHH	33.66	24719451
165	Acetylation	VTWVDSSKIKRHVLE HHHHCHHHHHHHHHH	57.08	25953088
165	Ubiquitination	VTWVDSSKIKRHVLE HHHHCHHHHHHHHHH	57.08	-
167	Ubiquitination	WVDSSKIKRHVLEYN HHCHHHHHHHHHHCC	39.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPP10_HUMAN	MPHOSPH10	physical	12655004
CCDB1_HUMAN	CCNDBP1	physical	19060904
USBP1_HUMAN	USHBP1	physical	25416956
KLC3_HUMAN	KLC3	physical	25416956
NOL10_HUMAN	NOL10	physical	26344197
RPAB5_HUMAN	POLR2L	physical	26344197
PWP2_HUMAN	PWP2	physical	26344197
RL17_HUMAN	RPL17	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.