B4GT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B4GT1_HUMAN
• UniProt AC: P15291
• Protein Name: Beta-1,4-galactosyltransferase 1
• Gene Name: B4GALT1
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Isoform Long: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Cell membrane ; Single-pass type II membrane protein. Cell surface . Cell projection, filopodium . Found in trans cisternae of Golgi but is mainly localized a
• Protein Description: The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.; The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix..
• Protein Sequence: MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	RLREPLLSGSAAMPG CCCCCCCCCCCCCCC	38.08	28555341
23	S-palmitoylation	GASLQRACRLLVAVC CHHHHHHHHHHHHHH	3.25	29575903
57	Phosphorylation	LPQLVGVSTPLQGGS CCCCCCCCCCCCCCC	20.55	23403867
57	O-linked_Glycosylation	LPQLVGVSTPLQGGS CCCCCCCCCCCCCCC	20.55	OGP
58	O-linked_Glycosylation	PQLVGVSTPLQGGSN CCCCCCCCCCCCCCC	26.13	OGP
58	Phosphorylation	PQLVGVSTPLQGGSN CCCCCCCCCCCCCCC	26.13	23403867
64	O-linked_Glycosylation	STPLQGGSNSAAAIG CCCCCCCCCCCHHHC	34.14	OGP
64	Phosphorylation	STPLQGGSNSAAAIG CCCCCCCCCCCHHHC	34.14	23403867
66	Phosphorylation	PLQGGSNSAAAIGQS CCCCCCCCCHHHCCC	22.45	23403867
66	O-linked_Glycosylation	PLQGGSNSAAAIGQS CCCCCCCCCHHHCCC	22.45	OGP
73	Phosphorylation	SAAAIGQSSGELRTG CCHHHCCCCCCCCCC	34.79	30278072
74	Phosphorylation	AAAIGQSSGELRTGG CHHHCCCCCCCCCCC	28.53	28355574
79	O-linked_Glycosylation	QSSGELRTGGARPPP CCCCCCCCCCCCCCC	53.22	OGP
113	N-linked_Glycosylation	SGPGPASNLTSVPVP CCCCCCCCCCCCCCC	49.82	UniProtKB CARBOHYD
115	O-linked_Glycosylation	PGPASNLTSVPVPHT CCCCCCCCCCCCCCC	31.74	OGP
204	Methylation	YLHPVLQRQQLDYGI HHHHHHHHHCCCCCE	23.27	-
270	Phosphorylation	FSQPRHISVAMDKFG HCCCCEEEEEHHHHC	9.56	-
279	O-linked_Glycosylation	AMDKFGFSLPYVQYF EHHHHCCCCCCHHHC	28.90	OGP
322	Ubiquitination	DDIFNRLVFRGMSIS CHHHHHHHHCCCCCC	2.51	21963094
344	Phosphorylation	RCRMIRHSRDKKNEP HHHHHCCCCCCCCCC	32.12	24719451
362	O-linked_Glycosylation	RFDRIAHTKETMLSD HHHHHHHHHHHHHHC	22.89	OGP
363	Ubiquitination	FDRIAHTKETMLSDG HHHHHHHHHHHHHCC	41.12	21963094
373	Phosphorylation	MLSDGLNSLTYQVLD HHHCCHHHCEEEEEC	27.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B4GT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B4GT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B4GT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LALBA_HUMAN	LALBA	physical	11947697
PLAK_HUMAN	JUP	physical	22939629
B4GT1_HUMAN	B4GALT1	physical	7744867
TBA1A_HUMAN	TUBA1A	physical	7744867
TBB5_HUMAN	TUBB	physical	7744867

Drug and Disease Associations

• Kegg Disease
• H00119: Congenital disorders of glycosylation (CDG) type II
• OMIM Disease
• 607091: Congenital disorder of glycosylation 2D (CDG2D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.