LALBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LALBA_HUMAN
• UniProt AC: P00709
• Protein Name: Alpha-lactalbumin
• Gene Name: LALBA
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Subcellular Localization: Secreted.
• Protein Description: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins..
• Protein Sequence: MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWLCEKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	QFTKCELSQLLKDID HCCHHHHHHHHHHCC	9.11	24719451
37	Nitration	LLKDIDGYGGIALPE HHHHCCCCCCCCHHH	14.39	-
64	N-linked_Glycosylation	TQAIVENNESTEYGL CEEEECCCCCCCEEE	30.96	18780401
90	N-linked_Glycosylation	SQVPQSRNICDISCD CCCCCCCCCCCCCCC	44.48	UniProtKB CARBOHYD
90	N-linked_Glycosylation	SQVPQSRNICDISCD CCCCCCCCCCCCCCC	44.48	9365923
105	Phosphorylation	KFLDDDITDDIMCAK CCCCCCCCHHHHHHH	34.31	-
122	Nitration	LDIKGIDYWLAHKAL HCCCCCCHHHHHHHH	10.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LALBA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LALBA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LALBA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_HUMAN	HSPA8	physical	20618441

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry.";
Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.;
Proteomics 8:3833-3847(2008).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64, AND MASS SPECTROMETRY.
PubMed: 18780401