RUSC2_HUMAN - dbPTM
RUSC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RUSC2_HUMAN
UniProt AC Q8N2Y8
Protein Name Iporin
Gene Name RUSC2
Organism Homo sapiens (Human).
Sequence Length 1516
Subcellular Localization Cytoplasm, cytosol . Cytosolic punctate distribution. Also observed in the perinuclear region.
Protein Description
Protein Sequence MDSPPKLTGETLIVHHIPLVHCQVPDRQCCGGAGGGGGSTRPNPFCPPELGITQPDQDLGQADSLLFSSLHSTPGGTARSIDSTKSRSRDGRGPGAPKRHNPFLLQEGVGEPGLGDLYDDSIGDSATQQSFHLHGTGQPNFHLSSFQLPPSGPRVGRPWGTTRSRAGVVEGQEQEPVMTLDTQQCGTSHCCRPELEAETMELDECGGPGGSGSGGGASDTSGFSFDQEWKLSSDESPRNPGCSGSGDQHCRCSSTSSQSEAADQSMGYVSDSSCNSSDGVLVTFSTLYNKMHGTPRANLNSAPQSCSDSSFCSHSDPGAFYLDLQPSPFESKMSYESHHPESGGREGGYGCPHASSPELDANCNSYRPHCEPCPAVADLTACFQSQARLVVATQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPGPDPGPSQPSEYYLFQKPEVQPEEQEAVSSSTQAAAAVGPTVLEGQVYTNTSPPNLSTGRQRSRSYDRSLQRSPPVRLGSLERMLSCPVRLSEGPAAMAGPGSPPRRVTSFAELAKGRKKTGGSGSPPLRVSVGDSSQEFSPIQEAQQDRGAPLDEGTCCSHSLPPMPLGPGMDLLGPDPSPPWSTQVCQGPHSSEMPPAGLRATGQGPLAQLMDPGPALPGSPANSHTQRDARARADGGGTESRPVLRYSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSGCSRTQQPAPLAAPAAQVSVPAPSGEPQASTPRATGRGARKAGSEPETSRPSPLGSYSPIRSVGPFGPSTDSSASTSCSPPPEQPTATESLPPWSHSCPSAVRPATSQQPQKEDQKILTLTEYRLHGTGSLPPLGSWRSGLSRAESLARGGGEGSMATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSLDRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPPAEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTLTPTPSPTPGSSQN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MDSPPKLTGE
-----CCCCCCCCCC		55.7723403867
8PhosphorylationMDSPPKLTGETLIVH
CCCCCCCCCCEEEEE		38.8128122231
11PhosphorylationPPKLTGETLIVHHIP
CCCCCCCEEEEEECC		24.1128122231
161PhosphorylationRVGRPWGTTRSRAGV
CCCCCCCCCCCCCCC		18.37-
162PhosphorylationVGRPWGTTRSRAGVV
CCCCCCCCCCCCCCC		23.78-
236PhosphorylationWKLSSDESPRNPGCS
EECCCCCCCCCCCCC		33.8625159151
243PhosphorylationSPRNPGCSGSGDQHC
CCCCCCCCCCCCCCC		41.7421712546
245PhosphorylationRNPGCSGSGDQHCRC
CCCCCCCCCCCCCCC		23.9321712546
321PhosphorylationHSDPGAFYLDLQPSP
CCCCCCEEEECCCCC		9.9627642862
335PhosphorylationPFESKMSYESHHPES
CCCCCCCCCCCCCCC		20.2527642862
342PhosphorylationYESHHPESGGREGGY
CCCCCCCCCCCCCCC		51.5025159151
349PhosphorylationSGGREGGYGCPHASS
CCCCCCCCCCCCCCC		26.8127732954
352UbiquitinationREGGYGCPHASSPEL
CCCCCCCCCCCCCCC		23.0121963094
355PhosphorylationGYGCPHASSPELDAN
CCCCCCCCCCCCCCC		43.3127732954
356PhosphorylationYGCPHASSPELDANC
CCCCCCCCCCCCCCC		24.1527732954
396PhosphorylationLVVATQNYYKLVTCD
EEEECCCEEEEEEEE		7.6725627689
397PhosphorylationVVATQNYYKLVTCDL
EEECCCEEEEEEEEC		12.8525627689
425UbiquitinationTSCSEEHTKISPPPG
CCCCCCCCCCCCCCC		33.0929967540
426UbiquitinationSCSEEHTKISPPPGP
CCCCCCCCCCCCCCC		42.9929967540
446PhosphorylationPSQPSEYYLFQKPEV
CCCCCEEEEEECCCC		9.2922817900
474PhosphorylationAAAAVGPTVLEGQVY
HHHHHCCEEEECEEE		31.62-
482PhosphorylationVLEGQVYTNTSPPNL
EEECEEECCCCCCCC		32.91-
498PhosphorylationTGRQRSRSYDRSLQR
CCCCCCCCCCHHHHC		32.4132645325
502PhosphorylationRSRSYDRSLQRSPPV
CCCCCCHHHHCCCCC		26.4223186163
506PhosphorylationYDRSLQRSPPVRLGS
CCHHHHCCCCCCCHH		22.1623917254
507UbiquitinationDRSLQRSPPVRLGSL
CHHHHCCCCCCCHHH		33.3329967540
513PhosphorylationSPPVRLGSLERMLSC
CCCCCCHHHHHHHCC		31.4821815630
519PhosphorylationGSLERMLSCPVRLSE
HHHHHHHCCCEECCC		13.6627499020
525PhosphorylationLSCPVRLSEGPAAMA
HCCCEECCCCCHHHC		29.9123186163
536PhosphorylationAAMAGPGSPPRRVTS
HHHCCCCCCCCHHCC		34.5630266825
542PhosphorylationGSPPRRVTSFAELAK
CCCCCHHCCHHHHHC		19.1325850435
543PhosphorylationSPPRRVTSFAELAKG
CCCCHHCCHHHHHCC		21.4323911959
554PhosphorylationLAKGRKKTGGSGSPP
HHCCCCCCCCCCCCC		50.2228450419
557PhosphorylationGRKKTGGSGSPPLRV
CCCCCCCCCCCCEEE		37.1328450419
559PhosphorylationKKTGGSGSPPLRVSV
CCCCCCCCCCEEEEC		25.6627794612
565PhosphorylationGSPPLRVSVGDSSQE
CCCCEEEECCCCCCC		17.5930576142
569PhosphorylationLRVSVGDSSQEFSPI
EEEECCCCCCCCCCH		28.1728450419
570PhosphorylationRVSVGDSSQEFSPIQ
EEECCCCCCCCCCHH		38.1728450419
574PhosphorylationGDSSQEFSPIQEAQQ
CCCCCCCCCHHHHHH		21.9726055452
656PhosphorylationPGPALPGSPANSHTQ
CCCCCCCCCCCCCCH		20.9218669648
660PhosphorylationLPGSPANSHTQRDAR
CCCCCCCCCCHHHHH		29.9821712546
720PhosphorylationLHSLSQLYSLSGCSR
HHHHHHHHHHHCCCC		10.42-
723PhosphorylationLSQLYSLSGCSRTQQ
HHHHHHHHCCCCCCC		31.6422210691
726PhosphorylationLYSLSGCSRTQQPAP
HHHHHCCCCCCCCCC		41.7222210691
728PhosphorylationSLSGCSRTQQPAPLA
HHHCCCCCCCCCCCC		18.4322210691
742PhosphorylationAAPAAQVSVPAPSGE
CCCCEEEEECCCCCC		15.42-
747PhosphorylationQVSVPAPSGEPQAST
EEEECCCCCCCCCCC		58.8722199227
753PhosphorylationPSGEPQASTPRATGR
CCCCCCCCCCCCCCC		33.4322199227
754PhosphorylationSGEPQASTPRATGRG
CCCCCCCCCCCCCCC		21.5822199227
767PhosphorylationRGARKAGSEPETSRP
CCCHHCCCCCCCCCC		55.6321712546
771PhosphorylationKAGSEPETSRPSPLG
HCCCCCCCCCCCCCC		40.5326699800
772PhosphorylationAGSEPETSRPSPLGS
CCCCCCCCCCCCCCC		40.3026699800
775PhosphorylationEPETSRPSPLGSYSP
CCCCCCCCCCCCCCC		31.4830266825
779PhosphorylationSRPSPLGSYSPIRSV
CCCCCCCCCCCCCCC		30.0730266825
780PhosphorylationRPSPLGSYSPIRSVG
CCCCCCCCCCCCCCC		19.3730266825
781PhosphorylationPSPLGSYSPIRSVGP
CCCCCCCCCCCCCCC		18.6230266825
839UbiquitinationQPQKEDQKILTLTEY
CCCCCCCCEEEEEEE		52.5929967540
851PhosphorylationTEYRLHGTGSLPPLG
EEEECCCCCCCCCCC		16.9223403867
853PhosphorylationYRLHGTGSLPPLGSW
EECCCCCCCCCCCCH		37.2222468782
859PhosphorylationGSLPPLGSWRSGLSR
CCCCCCCCHHCCHHH		27.3122468782
865PhosphorylationGSWRSGLSRAESLAR
CCHHCCHHHHHHHHC		32.73-
869PhosphorylationSGLSRAESLARGGGE
CCHHHHHHHHCCCCC		26.7523879269
884PhosphorylationGSMATRPSNANHLSP
CCCCCCCCCCCCCCH		45.3328555341
890PhosphorylationPSNANHLSPQALKWR
CCCCCCCCHHHHHHH		13.8626055452
911PhosphorylationPLGPPGLSGSLDRRS
CCCCCCCCCCCCHHH		32.0525850435
913PhosphorylationGPPGLSGSLDRRSQE
CCCCCCCCCCHHHHH		24.5821815630
1013PhosphorylationLIVAHFGTSRDPGVK
HHHHHHCCCCCCCCC		21.46-
1014PhosphorylationIVAHFGTSRDPGVKA
HHHHHCCCCCCCCCC		34.76-
1026PhosphorylationVKAKLGNSSVSPNVG
CCCCCCCCCCCCCHH		30.2528555341
1027PhosphorylationKAKLGNSSVSPNVGH
CCCCCCCCCCCCHHH		30.5228555341
1089PhosphorylationTKVLHGLYNKVSQFP
HHHHHHHHHHHHCCH		19.9624719451
1230UbiquitinationAAQGERVKGVGASEG
HHCCCCCCCCCCCCC		54.8421963094
1247PhosphorylationEEEEEEETEEVAEAA
HHHHHHHHHHHHHHH		40.50-
1303UbiquitinationSNSSSEKKKGAGGGG
CCCCCCCCCCCCCCC		53.0029967540
1304UbiquitinationNSSSEKKKGAGGGGP
CCCCCCCCCCCCCCC		66.1329967540
1347PhosphorylationGWPFWMGSPPDSVLA
CCCCCCCCCCHHHHH		19.7022199227
1351PhosphorylationWMGSPPDSVLAELRR
CCCCCCHHHHHHHHH		25.4629523821
1368PhosphorylationEREGPAASPAENEEG
HCCCCCCCHHCCCCC		27.0925159151
1380PhosphorylationEEGASEPSPGGIKWG
CCCCCCCCCCCCCHH		31.9325159151
1385UbiquitinationEPSPGGIKWGHLFGS
CCCCCCCCHHHHHCC		50.8529967540
1415PhosphorylationDWLSLDKSMFQLVAQ
HHHHCCHHHHHHHHH		25.2128555341
1435PhosphorylationREPEPKESLQEPHSP
CCCCCCHHCCCCCCC		41.2927251275
1441PhosphorylationESLQEPHSPALPSSP
HHCCCCCCCCCCCCC		23.6829449344
1446PhosphorylationPHSPALPSSPPCEVQ
CCCCCCCCCCCHHHH		57.2227251275
1447PhosphorylationHSPALPSSPPCEVQA
CCCCCCCCCCHHHHH		30.8127251275
1488O-linked_GlycosylationGGDWLRCSRGPDSGL
CCCCEECCCCCCCCC		33.5630379171
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RUSC2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RUSC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RUSC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ODO2_HUMANDLSTphysical
16169070
GOGA2_HUMANGOLGA2physical
15796781
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RUSC2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536; SER-656; SER-1368AND SER-1380, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND MASSSPECTROMETRY.

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