dbPTM

CY24A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CY24A_HUMAN	Jmol._Canvas2D (Jmol) "myJmol"[x]
UniProt AC	P13498
Protein Name	Cytochrome b-245 light chain
Gene Name	CYBA {ECO:0000312\|HGNC:HGNC:2577}
Organism	Homo sapiens (Human).
Sequence Length	195
Subcellular Localization	Cell membrane .
Protein Description	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide..
Protein Sequence	MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVFVCLLEYPRGKRKKGSTMERWGQKYMTAVVKLFGPFTRNYYVRAVLHLLLSVPAGFLLATILGTACLAIASGIYLLAAVRGEQWTPIEPKPRERPQIGGTIKQPPSNPPPRPPAEARKKPSEEEAAVAAGGPPGGPQVNPIPVTDEVV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Ubiquitination	EYPRGKRKKGSTMER HCCCCCCCCCCHHHH	66.04	21906983
61	Ubiquitination	YPRGKRKKGSTMERW CCCCCCCCCCHHHHH	63.23	21906983
64	Phosphorylation	GKRKKGSTMERWGQK CCCCCCCHHHHHHHH	31.55	28258704
71	Ubiquitination	TMERWGQKYMTAVVK HHHHHHHHHHHHHHH	32.81	21906983
72	Phosphorylation	MERWGQKYMTAVVKL HHHHHHHHHHHHHHH	7.57	-
78	Ubiquitination	KYMTAVVKLFGPFTR HHHHHHHHHHCCCCC	31.34	-
87	Phosphorylation	FGPFTRNYYVRAVLH HCCCCCHHHHHHHHH	10.47	-
88	Phosphorylation	GPFTRNYYVRAVLHL CCCCCHHHHHHHHHH	6.24	-
137	Ubiquitination	QWTPIEPKPRERPQI CCCCCCCCCCCCCCC	43.87	21906983
147	Phosphorylation	ERPQIGGTIKQPPSN CCCCCCCCCCCCCCC	21.56	21082442
149	Ubiquitination	PQIGGTIKQPPSNPP CCCCCCCCCCCCCCC	57.50	21906983
153	Phosphorylation	GTIKQPPSNPPPRPP CCCCCCCCCCCCCCC	69.52	26657352
168	Phosphorylation	AEARKKPSEEEAAVA HHHCCCCCHHHHHHH	67.53	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
147	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
147	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
147	T	Oxidation	19948736
Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
147	T	Phosphorylation	19948736
Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
149	K	ubiquitylation	-
Ubiquitinated at Lys-149 likely by RNF145.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CY24A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VHL_HUMAN	VHL	physical	17200123
NCF1_HUMAN	NCF1	physical	12056906
MDFI_HUMAN	MDFI	physical	19060904
ZN363_HUMAN	RCHY1	physical	21988832
PSA3_HUMAN	PSMA3	physical	25416956
RBPMS_HUMAN	RBPMS	physical	25416956

Drug and Disease Associations

Kegg Disease
H00098	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD);
H01167	Gluconobacter infection
OMIM Disease
233690	Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00514	Dextromethorphan

Regulatory Network of CY24A_HUMAN

Related Literatures of Post-Translational Modification