CSRP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSRP2_HUMAN
• UniProt AC: Q16527
• Protein Name: Cysteine and glycine-rich protein 2
• Gene Name: CSRP2
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Nucleus.
• Protein Description: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system..
• Protein Sequence: MPVWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDEEIYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESVQPHRPTTNPNTSKFAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KCGACGRTVYHAEEV CCCCCCCEEEEEEEE	15.65	28857561
28	Methylation	EEVQCDGRSFHRCCF EEEECCCCCHHHHHH	23.93	-
47	Phosphorylation	CRKNLDSTTVAIHDE HCCCCCCCEEEECCC	25.59	28555341
57	Phosphorylation	AIHDEEIYCKSCYGK EECCCEEEECCCCCC	9.34	28857561
60	Phosphorylation	DEEIYCKSCYGKKYG CCEEEECCCCCCCCC	14.71	28857561
62	Phosphorylation	EIYCKSCYGKKYGPK EEEECCCCCCCCCCC	38.79	12771930
65	Ubiquitination	CKSCYGKKYGPKGYG ECCCCCCCCCCCCCC	51.59	21890473
66	Phosphorylation	KSCYGKKYGPKGYGY CCCCCCCCCCCCCCC	41.99	22817900
69	Ubiquitination	YGKKYGPKGYGYGQG CCCCCCCCCCCCCCC	61.47	21890473
71	Phosphorylation	KKYGPKGYGYGQGAG CCCCCCCCCCCCCCC	17.19	30576142
73	Phosphorylation	YGPKGYGYGQGAGTL CCCCCCCCCCCCCEE	9.59	29978859
79	Phosphorylation	GYGQGAGTLNMDRGE CCCCCCCEECCCCCC	17.90	30576142
82	Sulfoxidation	QGAGTLNMDRGERLG CCCCEECCCCCCCCC	4.12	30846556
84	Methylation	AGTLNMDRGERLGIK CCEECCCCCCCCCCC	37.80	-
91	Sumoylation	RGERLGIKPESVQPH CCCCCCCCCCCCCCC	40.72	28112733
91	Sumoylation	RGERLGIKPESVQPH CCCCCCCCCCCCCCC	40.72	-
94	Phosphorylation	RLGIKPESVQPHRPT CCCCCCCCCCCCCCC	34.28	28857561
101	Phosphorylation	SVQPHRPTTNPNTSK CCCCCCCCCCCCHHH	38.88	28555341
106	Phosphorylation	RPTTNPNTSKFAQKY CCCCCCCHHHHHHHH	34.25	28555341
112	Acetylation	NTSKFAQKYGGAEKC CHHHHHHHHCCCHHC	42.29	23236377
118	Sumoylation	QKYGGAEKCSRCGDS HHHCCCHHCCCCCCH	36.66	-
118	Sumoylation	QKYGGAEKCSRCGDS HHHCCCHHCCCCCCH	36.66	-
125	Phosphorylation	KCSRCGDSVYAAEKI HCCCCCCHHHHHHHH	11.43	25072903
127	Phosphorylation	SRCGDSVYAAEKIIG CCCCCHHHHHHHHHC	12.21	26437602
131	Acetylation	DSVYAAEKIIGAGKP CHHHHHHHHHCCCCC	34.59	-
137	Succinylation	EKIIGAGKPWHKNCF HHHHCCCCCCCCCCH	44.38	-
137	Succinylation	EKIIGAGKPWHKNCF HHHHCCCCCCCCCCH	44.38	-
137	Acetylation	EKIIGAGKPWHKNCF HHHHCCCCCCCCCCH	44.38	-
152	Phosphorylation	RCAKCGKSLESTTLT HHHCCCCCCCCCCCC	23.74	21406692
155	Phosphorylation	KCGKSLESTTLTEKE CCCCCCCCCCCCEEC	31.80	21406692
156	Phosphorylation	CGKSLESTTLTEKEG CCCCCCCCCCCEECC	19.22	28857561
157	Phosphorylation	GKSLESTTLTEKEGE CCCCCCCCCCEECCE	40.75	21406692
159	Phosphorylation	SLESTTLTEKEGEIY CCCCCCCCEECCEEE	42.81	21406692
161	Acetylation	ESTTLTEKEGEIYCK CCCCCCEECCEEEEC	66.82	-
171	Phosphorylation	EIYCKGCYAKNFGPK EEEECCCEECCCCCC	29.31	-
173	Ubiquitination	YCKGCYAKNFGPKGF EECCCEECCCCCCCC	26.74	-
178	Sumoylation	YAKNFGPKGFGYGQG EECCCCCCCCCCCCC	68.22	-
178	Sumoylation	YAKNFGPKGFGYGQG EECCCCCCCCCCCCC	68.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSRP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSRP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSRP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIAS1_HUMAN	PIAS1	physical	11672422
CSR2B_HUMAN	CSRP2BP	physical	10924333
TRI27_HUMAN	TRIM27	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.