ZNF48_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF48_HUMAN
• UniProt AC: Q96MX3
• Protein Name: Zinc finger protein 48
• Gene Name: ZNF48
• Organism: Homo sapiens (Human).
• Sequence Length: 618
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MERAVEPWGPDLHRPEEREPQRGARTGLGSENVISQPNEFEHTPQEDDLGFKEEDLAPDHEVGNASLKPEGIQNWDDLWVQREGLGKPQPRDRGPRLLGEPRWGQASSDRAAVCGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHSGEKPYRARPPAQGPPKIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRTHRGEQPPRPVVPRRQPSRAATAATQGPKAQDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGERPHACPECDRTFSLSSTLLRHRLTHMEPQDFSFPGYPLPALIPSPPPPPLGTSPPLTPRSPSHSGEPFGLPGLEPEPGGPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLRTHRGERARPPPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHTGEKPYKCAECGKGFGDSSARIKHQRGHLVLTPFGIGDGRARPLKQEAATGLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MERAVEPW -------CCCCCCCC	7.69	-
87	Sumoylation	VQREGLGKPQPRDRG EECCCCCCCCCCCCC	45.59	28112733
125	Phosphorylation	GKSFRQMSDLVKHQR HHHHHHHHHHHHHCC	21.32	20860994
133	Phosphorylation	DLVKHQRTHTGEKPY HHHHHCCCCCCCCCE	19.74	28348404
135	Phosphorylation	VKHQRTHTGEKPYKC HHHCCCCCCCCCEEC	46.56	26270265
138	Ubiquitination	QRTHTGEKPYKCGVC CCCCCCCCCEECCCC	55.80	-
140	Phosphorylation	THTGEKPYKCGVCGK CCCCCCCEECCCCCC	29.94	-
147	Trimethylation	YKCGVCGKGFGDSSA EECCCCCCCCCCCCH	46.03	-
147	Methylation	YKCGVCGKGFGDSSA EECCCCCCCCCCCCH	46.03	-
152	Phosphorylation	CGKGFGDSSARIKHQ CCCCCCCCCHHCCCC	26.69	27251275
153	Phosphorylation	GKGFGDSSARIKHQR CCCCCCCCHHCCCCC	26.72	27251275
157	Trimethylation	GDSSARIKHQRTHSG CCCCHHCCCCCCCCC	28.29	-
157	Methylation	GDSSARIKHQRTHSG CCCCHHCCCCCCCCC	28.29	-
161	Phosphorylation	ARIKHQRTHSGEKPY HHCCCCCCCCCCCCC	17.52	29083192
163	Phosphorylation	IKHQRTHSGEKPYRA CCCCCCCCCCCCCCC	48.29	29083192
168	Phosphorylation	THSGEKPYRARPPAQ CCCCCCCCCCCCCCC	28.15	29083192
179	Sumoylation	PPAQGPPKIPRSRIP CCCCCCCCCCHHHCC	69.36	28112733
183	Phosphorylation	GPPKIPRSRIPAGER CCCCCCHHHCCCCCC	29.25	29449344
209	Acetylation	RQSSDLVKHQRTHTG HHHHHHHHCCCCCCC	41.12	20167786
213	Phosphorylation	DLVKHQRTHTGEKPY HHHHCCCCCCCCCCE	19.74	28348404
215	Phosphorylation	VKHQRTHTGEKPYKC HHCCCCCCCCCCEEC	46.56	24719451
218	Ubiquitination	QRTHTGEKPYKCGIC CCCCCCCCCEECCCC	55.80	-
232	Phosphorylation	CGKGFGDSSARIKHQ CCCCCCCCCHHCCCC	26.69	27251275
233	Phosphorylation	GKGFGDSSARIKHQR CCCCCCCCHHCCCCC	26.72	27251275
258	Phosphorylation	VVPRRQPSRAATAAT CCCCCCCCHHHHHHH	26.64	24173317
262	Phosphorylation	RQPSRAATAATQGPK CCCCHHHHHHHCCCC	18.81	28509920
265	Phosphorylation	SRAATAATQGPKAQD CHHHHHHHCCCCCCC	31.43	28509920
269	Sumoylation	TAATQGPKAQDKPYI HHHHCCCCCCCCCEE	66.56	28112733
316	Phosphorylation	GKEFARGSDLVKHLR CCCCCCCCHHHHHEE	23.40	25159151
326	Phosphorylation	VKHLRVHTGEKPYLC HHHEEECCCCCCEEC	44.15	26055452
329	Sumoylation	LRVHTGEKPYLCPEC EEECCCCCCEECCCC	40.06	28112733
331	Phosphorylation	VHTGEKPYLCPECGK ECCCCCCEECCCCCC	31.81	28152594
343	Phosphorylation	CGKGFADSSARVKHL CCCCCCCCHHHHHHH	23.59	27794612
344	Phosphorylation	GKGFADSSARVKHLR CCCCCCCHHHHHHHH	22.20	29743597
352	Phosphorylation	ARVKHLRTHSGERPH HHHHHHHHCCCCCCC	27.10	29449344
354	Phosphorylation	VKHLRTHSGERPHAC HHHHHHCCCCCCCCC	41.56	29214152
369	Phosphorylation	PECDRTFSLSSTLLR CCCCCEEEHHHHHHH	27.08	28555341
400	Phosphorylation	PLPALIPSPPPPPLG CCCCCCCCCCCCCCC	42.94	28122231
408	Phosphorylation	PPPPPLGTSPPLTPR CCCCCCCCCCCCCCC	45.82	28348404
409	Phosphorylation	PPPPLGTSPPLTPRS CCCCCCCCCCCCCCC	23.79	28348404
413	Phosphorylation	LGTSPPLTPRSPSHS CCCCCCCCCCCCCCC	23.56	28122231
416	Phosphorylation	SPPLTPRSPSHSGEP CCCCCCCCCCCCCCC	31.77	21082442
418	Phosphorylation	PLTPRSPSHSGEPFG CCCCCCCCCCCCCCC	31.37	23663014
420	Phosphorylation	TPRSPSHSGEPFGLP CCCCCCCCCCCCCCC	49.54	25022875
463	Phosphorylation	CGKGFRRSSDLVKHH CCCCCCCCHHHHHHC	24.77	20873877
464	Phosphorylation	GKGFRRSSDLVKHHR CCCCCCCHHHHHHCC	32.90	20873877
474	Phosphorylation	VKHHRVHTGEKPYLC HHHCCCCCCCCCEEC	44.15	28387310
477	Sumoylation	HRVHTGEKPYLCPEC CCCCCCCCCEECCCC	40.06	28112733
479	Phosphorylation	VHTGEKPYLCPECGK CCCCCCCEECCCCCC	31.81	28152594
491	Phosphorylation	CGKGFADSSARVKHL CCCCCCCCHHHHHHH	23.59	27794612
492	Phosphorylation	GKGFADSSARVKHLR CCCCCCCHHHHHHHH	22.20	27794612
537	Phosphorylation	PRVRAQPSGPSQPHV CCCCCCCCCCCCCCC	51.78	28555341
564	Phosphorylation	DLVKHRRTHTGEKPY HHHHCCCCCCCCCCE	24.60	28348404
566	Phosphorylation	VKHRRTHTGEKPYKC HHCCCCCCCCCCEEC	46.56	26270265
569	Ubiquitination	RRTHTGEKPYKCAEC CCCCCCCCCEECCCC	55.80	-
583	Phosphorylation	CGKGFGDSSARIKHQ CCCCCCCHHHHEEEC	26.69	27251275
584	Phosphorylation	GKGFGDSSARIKHQR CCCCCCHHHHEEECC	26.72	27251275
597	Phosphorylation	QRGHLVLTPFGIGDG CCCCEEECCCCCCCC	14.75	23898821
610	Sumoylation	DGRARPLKQEAATGL CCCCCCCHHHHHHCC	49.10	28112733
610	Sumoylation	DGRARPLKQEAATGL CCCCCCCHHHHHHCC	49.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF48_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF48_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF48_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZNF48_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.