dbPTM

AL9A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AL9A1_HUMAN
UniProt AC	P49189
Protein Name	4-trimethylaminobutyraldehyde dehydrogenase
Gene Name	ALDH9A1
Organism	Homo sapiens (Human).
Sequence Length	494
Subcellular Localization	Cytoplasm.
Protein Description	Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction..
Protein Sequence	MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTGTFVVS ------CCCCEEEEC	35.23	22223895
2	Phosphorylation	------MSTGTFVVS ------CCCCEEEEC	35.23	20068231
3	Phosphorylation	-----MSTGTFVVSQ -----CCCCEEEECC	38.65	20068231
5	Phosphorylation	---MSTGTFVVSQPL ---CCCCEEEECCCC	17.22	20068231
9	Phosphorylation	STGTFVVSQPLNYRG CCCEEEECCCCCCCC	22.30	20068231
11	Phosphorylation	GTFVVSQPLNYRGGA CEEEECCCCCCCCCC	18.31	18669648
14	Phosphorylation	VVSQPLNYRGGARVE EECCCCCCCCCCEEC	20.51	24043423
15	Methylation	VSQPLNYRGGARVEP ECCCCCCCCCCEECC	35.68	-
20	Phosphorylation	NYRGGARVEPADASG CCCCCCEECCCCCCC	11.65	27251275
26	Acetylation	RVEPADASGTEKAFE EECCCCCCCCCCCCC	46.96	20068231
26	Phosphorylation	RVEPADASGTEKAFE EECCCCCCCCCCCCC	46.96	20068231
28	Phosphorylation	EPADASGTEKAFEPA CCCCCCCCCCCCCCC	31.64	26437602
30	Acetylation	ADASGTEKAFEPATG CCCCCCCCCCCCCCC	59.21	23954790
30	Malonylation	ADASGTEKAFEPATG CCCCCCCCCCCCCCC	59.21	26320211
30	Succinylation	ADASGTEKAFEPATG CCCCCCCCCCCCCCC	59.21	-
30	Succinylation	ADASGTEKAFEPATG CCCCCCCCCCCCCCC	59.21	21890473
30	Ubiquitination	ADASGTEKAFEPATG CCCCCCCCCCCCCCC	59.21	21890473
31	Ubiquitination	DASGTEKAFEPATGR CCCCCCCCCCCCCCC	14.06	24816145
33	Phosphorylation	SGTEKAFEPATGRVI CCCCCCCCCCCCCEE	38.60	20068231
42	Phosphorylation	ATGRVIATFTCSGEK CCCCEEEEEEECCCE	14.35	26437602
44	Phosphorylation	GRVIATFTCSGEKEV CCEEEEEEECCCEEH	11.04	21406692
45	Glutathionylation	RVIATFTCSGEKEVN CEEEEEEECCCEEHH	4.26	22555962
46	Phosphorylation	VIATFTCSGEKEVNL EEEEEEECCCEEHHH	47.10	21406692
49	Acetylation	TFTCSGEKEVNLAVQ EEEECCCEEHHHHHH	71.18	26051181
49	Ubiquitination	TFTCSGEKEVNLAVQ EEEECCCEEHHHHHH	71.18	-
54	Ubiquitination	GEKEVNLAVQNAKAA CCEEHHHHHHHHHHH	8.81	21890473
54	Ubiquitination	GEKEVNLAVQNAKAA CCEEHHHHHHHHHHH	8.81	21890473
54	Ubiquitination	GEKEVNLAVQNAKAA CCEEHHHHHHHHHHH	8.81	27667366
59	Acetylation	NLAVQNAKAAFKIWS HHHHHHHHHHHHHHH	48.04	27452117
59	Succinylation	NLAVQNAKAAFKIWS HHHHHHHHHHHHHHH	48.04	-
59	Succinylation	NLAVQNAKAAFKIWS HHHHHHHHHHHHHHH	48.04	-
59	Ubiquitination	NLAVQNAKAAFKIWS HHHHHHHHHHHHHHH	48.04	-
63	Acetylation	QNAKAAFKIWSQKSG HHHHHHHHHHHCCCH	38.24	25953088
66	Phosphorylation	KAAFKIWSQKSGMER HHHHHHHHCCCHHHH	31.07	30576142
68	Acetylation	AFKIWSQKSGMERCR HHHHHHCCCHHHHHH	43.38	25953088
68	Ubiquitination	AFKIWSQKSGMERCR HHHHHHCCCHHHHHH	43.38	21890473
83	Ubiquitination	ILLEAARIIREREDE HHHHHHHHHHHCCCC	2.74	29967540
87	Ubiquitination	AARIIREREDEIATM HHHHHHHCCCCCEEE	46.98	23000965
92	Ubiquitination	REREDEIATMECINN HHCCCCCEEEEEHHC	9.99	-
92	Neddylation	REREDEIATMECINN HHCCCCCEEEEEHHC	9.99	32015554
92	Ubiquitination	REREDEIATMECINN HHCCCCCEEEEEHHC	9.99	23000965
93	Phosphorylation	EREDEIATMECINNG HCCCCCEEEEEHHCC	21.11	24114839
94	Sulfoxidation	REDEIATMECINNGK CCCCCEEEEEHHCCC	2.67	30846556
101	Acetylation	MECINNGKSIFEARL EEEHHCCCCCEEEEE	42.37	26051181
113	Phosphorylation	ARLDIDISWQCLEYY EEECCCCCHHHHHHH	13.82	23663014
119	Phosphorylation	ISWQCLEYYAGLAAS CCHHHHHHHHHHHHH	5.90	23663014
120	Phosphorylation	SWQCLEYYAGLAASM CHHHHHHHHHHHHHH	5.70	23663014
125	Ubiquitination	EYYAGLAASMAGEHI HHHHHHHHHHCCCCC	12.60	24816145
126	Phosphorylation	YYAGLAASMAGEHIQ HHHHHHHHHCCCCCC	11.98	23663014
138	Phosphorylation	HIQLPGGSFGYTRRE CCCCCCCCCCCCCCC	22.78	23663014
141	Phosphorylation	LPGGSFGYTRREPLG CCCCCCCCCCCCCCC	8.61	23663014
142	Phosphorylation	PGGSFGYTRREPLGV CCCCCCCCCCCCCCE	24.51	23663014
164	Phosphorylation	NYPFQIASWKSAPAL CCCEEEECCCCCCEE	36.34	24719451
169	Ubiquitination	IASWKSAPALACGNA EECCCCCCEEECCCE	34.59	-
176	Ubiquitination	PALACGNAMVFKPSP CEEECCCEEEECCCC	4.84	-
179	Ubiquitination	ACGNAMVFKPSPFTP ECCCEEEECCCCCCC	6.55	-
228	Ubiquitination	QHPDVAKVSFTGSVP CCCCEEEEEEECCCC	4.03	-
228	Ubiquitination	QHPDVAKVSFTGSVP CCCCEEEEEEECCCC	4.03	23000965
229	Phosphorylation	HPDVAKVSFTGSVPT CCCEEEEEEECCCCC	19.18	20068231
231	Phosphorylation	DVAKVSFTGSVPTGM CEEEEEEECCCCCCC	22.50	28857561
233	Acetylation	AKVSFTGSVPTGMKI EEEEEECCCCCCCCC	23.13	-
233	Ubiquitination	AKVSFTGSVPTGMKI EEEEEECCCCCCCCC	23.13	-
233	Phosphorylation	AKVSFTGSVPTGMKI EEEEEECCCCCCCCC	23.13	20068231
233	Ubiquitination	AKVSFTGSVPTGMKI EEEEEECCCCCCCCC	23.13	21890473
236	Phosphorylation	SFTGSVPTGMKIMEM EEECCCCCCCCCEEE	47.99	26437602
238	Sulfoxidation	TGSVPTGMKIMEMSA ECCCCCCCCCEEECC	2.68	21406390
239	Acetylation	GSVPTGMKIMEMSAK CCCCCCCCCEEECCC	40.00	25038526
239	Ubiquitination	GSVPTGMKIMEMSAK CCCCCCCCCEEECCC	40.00	-
240	Acetylation	SVPTGMKIMEMSAKG CCCCCCCCEEECCCC	1.78	-
240	Ubiquitination	SVPTGMKIMEMSAKG CCCCCCCCEEECCCC	1.78	-
240	Ubiquitination	SVPTGMKIMEMSAKG CCCCCCCCEEECCCC	1.78	22817900
246	Ubiquitination	KIMEMSAKGIKPVTL CCEEECCCCCCCEEE	54.59	-
246	Acetylation	KIMEMSAKGIKPVTL CCEEECCCCCCCEEE	54.59	26051181
246	Ubiquitination	KIMEMSAKGIKPVTL CCEEECCCCCCCEEE	54.59	30230243
249	Ubiquitination	EMSAKGIKPVTLELG EECCCCCCCEEEECC	41.95	-
253	Phosphorylation	KGIKPVTLELGGKSP CCCCCEEEECCCCCC	5.35	20068231
257	Phosphorylation	PVTLELGGKSPLIIF CEEEECCCCCCEEEE	39.63	24719451
263	Ubiquitination	GGKSPLIIFSDCDMN CCCCCEEEEECCCCC	3.40	29967540
267	Glutathionylation	PLIIFSDCDMNNAVK CEEEEECCCCCHHHH	5.32	22555962
269	Sulfoxidation	IIFSDCDMNNAVKGA EEEECCCCCHHHHHH	5.39	30846556
270	Ubiquitination	IFSDCDMNNAVKGAL EEECCCCCHHHHHHH	21.76	29967540
273	Ubiquitination	DCDMNNAVKGALMAN CCCCCHHHHHHHHHH	6.80	29967540
274	Acetylation	CDMNNAVKGALMANF CCCCHHHHHHHHHHC	35.74	-
274	Ubiquitination	CDMNNAVKGALMANF CCCCHHHHHHHHHHC	35.74	-
274	Ubiquitination	CDMNNAVKGALMANF CCCCHHHHHHHHHHC	35.74	20639865
277	Ubiquitination	NNAVKGALMANFLTQ CHHHHHHHHHHCCCC	4.55	20639865
282	Ubiquitination	GALMANFLTQGQVCC HHHHHHCCCCCCCCC	3.33	29967540
298	Acetylation	GTRVFVQKEILDKFT CEEEEEEHHHHHHHH	41.23	19608861
298	Ubiquitination	GTRVFVQKEILDKFT CEEEEEEHHHHHHHH	41.23	27667366
303	Acetylation	VQKEILDKFTEEVVK EEHHHHHHHHHHHHH	51.22	23954790
303	Succinylation	VQKEILDKFTEEVVK EEHHHHHHHHHHHHH	51.22	-
303	Succinylation	VQKEILDKFTEEVVK EEHHHHHHHHHHHHH	51.22	21890473
303	Ubiquitination	VQKEILDKFTEEVVK EEHHHHHHHHHHHHH	51.22	21890473
310	Acetylation	KFTEEVVKQTQRIKI HHHHHHHHHHCCCCC	53.45	25038526
310	Malonylation	KFTEEVVKQTQRIKI HHHHHHHHHHCCCCC	53.45	26320211
310	Ubiquitination	KFTEEVVKQTQRIKI HHHHHHHHHHCCCCC	53.45	-
316	Malonylation	VKQTQRIKIGDPLLE HHHHCCCCCCCCCCC	42.71	26320211
316	Ubiquitination	VKQTQRIKIGDPLLE HHHHCCCCCCCCCCC	42.71	-
322	Acetylation	IKIGDPLLEDTRMGP CCCCCCCCCCCCCCC	7.33	19608861
322	Ubiquitination	IKIGDPLLEDTRMGP CCCCCCCCCCCCCCC	7.33	23000965
327	Ubiquitination	PLLEDTRMGPLINRP CCCCCCCCCCCCCCH	7.62	21890473
327	Ubiquitination	PLLEDTRMGPLINRP CCCCCCCCCCCCCCH	7.62	21890473
327	Ubiquitination	PLLEDTRMGPLINRP CCCCCCCCCCCCCCH	7.62	21890473
334	Ubiquitination	MGPLINRPHLERVLG CCCCCCCHHHHHHHH	31.74	22817900
340	Ubiquitination	RPHLERVLGFVKVAK CHHHHHHHHHHHHHH	5.73	30230243
344	Acetylation	ERVLGFVKVAKEQGA HHHHHHHHHHHHCCC	33.93	23236377
344	Ubiquitination	ERVLGFVKVAKEQGA HHHHHHHHHHHHCCC	33.93	20639865
347	Ubiquitination	LGFVKVAKEQGAKVL HHHHHHHHHCCCEEE	54.26	2063986
352	Acetylation	VAKEQGAKVLCGGDI HHHHCCCEEEECCCE	42.43	26051181
355	Glutathionylation	EQGAKVLCGGDIYVP HCCCEEEECCCEECC	6.83	22555962
360	Phosphorylation	VLCGGDIYVPEDPKL EEECCCEECCCCCCC	18.07	7442915
366	Acetylation	IYVPEDPKLKDGYYM EECCCCCCCCCCEEE	79.20	26051181
368	Ubiquitination	VPEDPKLKDGYYMRP CCCCCCCCCCEEECC	56.06	20639865
371	Ubiquitination	DPKLKDGYYMRPCVL CCCCCCCEEECCEEE	12.29	20639865
376	Ubiquitination	DGYYMRPCVLTNCRD CCEEECCEEEECCCC	2.50	29967540
390	Ubiquitination	DDMTCVKEEIFGPVM CCCHHHHHHHHHCCE	35.61	29967540
392	Ubiquitination	MTCVKEEIFGPVMSI CHHHHHHHHHCCEEE	5.19	27667366
416	Phosphorylation	LERANDTTFGLAAGV HHHCCCCCCCCEEEE	20.69	24076635
442	Phosphorylation	VAELQAGTCFINNYN HHHHHCCCEEEECCC	13.78	22468782
451	Phosphorylation	FINNYNVSPVELPFG EEECCCCCCEECCCC	21.42	22468782
460	Phosphorylation	VELPFGGYKKSGFGR EECCCCCCCCCCCCC	18.67	22468782
461	Acetylation	ELPFGGYKKSGFGRE ECCCCCCCCCCCCCC	43.68	155651
462	Acetylation	LPFGGYKKSGFGREN CCCCCCCCCCCCCCC	47.53	24430995
473	Phosphorylation	GRENGRVTIEYYSQL CCCCCEEEEEEECCC	13.51	26356563
476	Phosphorylation	NGRVTIEYYSQLKTV CCEEEEEEECCCCEE	12.45	28102081
477	Phosphorylation	GRVTIEYYSQLKTVC CEEEEEEECCCCEEE	4.16	28152594
478	Phosphorylation	RVTIEYYSQLKTVCV EEEEEEECCCCEEEE	28.30	28152594
482	Phosphorylation	EYYSQLKTVCVEMGD EEECCCCEEEEECCC	27.94	29083192
484	Glutathionylation	YSQLKTVCVEMGDVE ECCCCEEEEECCCHH	2.31	22555962
487	Sulfoxidation	LKTVCVEMGDVESAF CCEEEEECCCHHHCC	2.50	30846556
492	Phosphorylation	VEMGDVESAF----- EECCCHHHCC-----	34.52	29083192
497	Phosphorylation	VESAF---------- HHHCC----------		20068231
500	Phosphorylation	AF------------- CC-------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AL9A1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AL9A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AL9A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
THIC_HUMAN	ACAT2	physical	22863883
CPIN1_HUMAN	CIAPIN1	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AL9A1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-298, AND MASS SPECTROMETRY.	19608861 [Abstract]