PHF11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHF11_HUMAN
• UniProt AC: Q9UIL8
• Protein Name: PHD finger protein 11
• Gene Name: PHF11
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Subcellular Localization: Nucleus .
• Protein Description: Positive regulator of Th1-type cytokine gene expression..
• Protein Sequence: MAQASPPRPERVLGASSPEARPAQEALLLPTGVFQVAEKMEKRTCALCPKDVEYNVLYFAQSENIAAHENCLLYSSGLVECEDQDPLNPDRSFDVESVKKEIQRGRKLKCKFCHKRGATVGCDLKNCNKNYHFFCAKKDDAVPQSDGVRGIYKLLCQQHAQFPIIAQSAKFSGVKRKRGRKKPLSGNHVQPPETMKCNTFIRQVKEEHGRHTDATVKVPFLKKCKEAGLLNYLLEEILDKVHSIPEKLMDETTSESDYEEIGSALFDCRLFEDTFVNFQAAIEKKIHASQQRWQQLKEEIELLQDLKQTLCSFQENRDLMSSSTSISSLSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAQASPPRPERV ---CCCCCCCCHHHC	24.29	23401153
16	Phosphorylation	PERVLGASSPEARPA HHHCCCCCCCCCCHH	44.63	28102081
17	Phosphorylation	ERVLGASSPEARPAQ HHCCCCCCCCCCHHH	26.65	23401153
31	Phosphorylation	QEALLLPTGVFQVAE HHHHHCCCCHHHHHH	46.04	24732914
39	Ubiquitination	GVFQVAEKMEKRTCA CHHHHHHHHHHCCCC	42.49	-
92	Phosphorylation	DPLNPDRSFDVESVK CCCCCCCCCCHHHHH	32.93	29116813
99	Ubiquitination	SFDVESVKKEIQRGR CCCHHHHHHHHHHCC	54.70	-
100	Ubiquitination	FDVESVKKEIQRGRK CCHHHHHHHHHHCCC	58.87	-
125	Ubiquitination	ATVGCDLKNCNKNYH CEEECCCCCCCCCEE	46.32	-
138	Ubiquitination	YHFFCAKKDDAVPQS EEEEEEECCCCCCCC	42.17	-
153	Ubiquitination	DGVRGIYKLLCQQHA CCHHHHHHHHHHHHC	32.82	-
170	Ubiquitination	PIIAQSAKFSGVKRK CHHHCHHCCCCCCCC	45.36	-
185	Phosphorylation	RGRKKPLSGNHVQPP CCCCCCCCCCCCCCC	46.18	24719451
194	Phosphorylation	NHVQPPETMKCNTFI CCCCCCCHHCHHHHH	27.92	24719451
217	Ubiquitination	RHTDATVKVPFLKKC CCCCCEEECCHHHHH	39.57	-
243	Phosphorylation	EILDKVHSIPEKLMD HHHHHHHCCCHHHHC	42.71	-
252	Phosphorylation	PEKLMDETTSESDYE CHHHHCCCCCHHHHH	31.21	30108239
253	Phosphorylation	EKLMDETTSESDYEE HHHHCCCCCHHHHHH	28.57	30108239
254	Phosphorylation	KLMDETTSESDYEEI HHHCCCCCHHHHHHH	42.39	24719451
256	Phosphorylation	MDETTSESDYEEIGS HCCCCCHHHHHHHHH	45.30	30108239
258	Phosphorylation	ETTSESDYEEIGSAL CCCCHHHHHHHHHHH	25.41	30108239
263	Phosphorylation	SDYEEIGSALFDCRL HHHHHHHHHHHHCEE	27.71	30108239
285	Ubiquitination	FQAAIEKKIHASQQR HHHHHHHHHHHHHHH	27.25	-
297	Ubiquitination	QQRWQQLKEEIELLQ HHHHHHHHHHHHHHH	49.30	-
307	Ubiquitination	IELLQDLKQTLCSFQ HHHHHHHHHHHHHHH	49.91	-
321	Phosphorylation	QENRDLMSSSTSISS HHCHHHHHCCCCCHH	28.56	-
323	Phosphorylation	NRDLMSSSTSISSLS CHHHHHCCCCCHHCC	20.90	30576142
324	Phosphorylation	RDLMSSSTSISSLSY HHHHHCCCCCHHCCC	31.84	28387310
327	Phosphorylation	MSSSTSISSLSY--- HHCCCCCHHCCC---	25.62	27251275
328	Phosphorylation	SSSTSISSLSY---- HCCCCCHHCCC----	21.47	27251275
330	Phosphorylation	STSISSLSY------ CCCCHHCCC------	30.64	28387310

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHF11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHF11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHF11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIAS4_HUMAN	PIAS4	physical	21988832
ST1A2_HUMAN	SULT1A2	physical	26186194
ST1A2_HUMAN	SULT1A2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.