dbPTM

CASA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CASA1_HUMAN
UniProt AC	P47710
Protein Name	Alpha-S1-casein
Gene Name	CSN1S1
Organism	Homo sapiens (Human).
Sequence Length	185
Subcellular Localization	Secreted.
Protein Description	Important role in the capacity of milk to transport calcium phosphate.; Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors..
Protein Sequence	MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQTDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQEQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNNVMLQW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	PERLQNPSESSEPIP HHHHCCCCCCCCCCC	58.63	20068231
33	Phosphorylation	RLQNPSESSEPIPLE HHCCCCCCCCCCCCC	44.32	17646876
34	Phosphorylation	LQNPSESSEPIPLES HCCCCCCCCCCCCCH	43.25	20068231
41	Phosphorylation	SEPIPLESREEYMNG CCCCCCCHHHHHHHH	53.31	17646876
71	Phosphorylation	IKDTRNESTQNCVVA HHHCCCHHCCCEEEE	38.55	27251275
72	Phosphorylation	KDTRNESTQNCVVAE HHCCCHHCCCEEEEC	20.02	27251275
85	Phosphorylation	AEPEKMESSISSSSE ECHHHHHHHCCCCCH	29.49	28450419
86	Phosphorylation	EPEKMESSISSSSEE CHHHHHHHCCCCCHH	17.12	28450419
88	Phosphorylation	EKMESSISSSSEEMS HHHHHHCCCCCHHHC	26.56	17646876
89	Phosphorylation	KMESSISSSSEEMSL HHHHHCCCCCHHHCH	35.89	28450419
90	Phosphorylation	MESSISSSSEEMSLS HHHHCCCCCHHHCHH	34.67	17646876
91	Phosphorylation	ESSISSSSEEMSLSK HHHCCCCCHHHCHHH	39.25	7619062
95	Phosphorylation	SSSSEEMSLSKCAEQ CCCCHHHCHHHHHHH	32.54	28450419
97	Phosphorylation	SSEEMSLSKCAEQFC CCHHHCHHHHHHHHH	20.55	28450419
130	Phosphorylation	IRRMNENSHVQVPFQ HHHHHCCCCCCCCHH	20.89	26330541
145	Phosphorylation	QLNQLAAYPYAVWYY HHHHHHHHCHHHHHC	7.38	26330541
147	Phosphorylation	NQLAAYPYAVWYYPQ HHHHHHCHHHHHCCH	10.91	26330541
151	Phosphorylation	AYPYAVWYYPQIMQY HHCHHHHHCCHHHHH	9.92	26330541
152	Phosphorylation	YPYAVWYYPQIMQYV HCHHHHHCCHHHHHC	3.49	26330541
158	Phosphorylation	YYPQIMQYVPFPPFS HCCHHHHHCCCCCCC	7.84	26330541
165	Phosphorylation	YVPFPPFSDISNPTA HCCCCCCCCCCCCCC	39.55	26330541
168	Phosphorylation	FPPFSDISNPTAHEN CCCCCCCCCCCCCCC	41.57	26330541
171	Phosphorylation	FSDISNPTAHENYEK CCCCCCCCCCCCHHH	44.92	26330541
176	Phosphorylation	NPTAHENYEKNNVML CCCCCCCHHHCCCCC	25.87	26330541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CASA1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CASA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CASA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDE10_HUMAN	PDE10A	physical	28514442
B4GN4_HUMAN	B4GALNT4	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
EMIL3_HUMAN	EMILIN3	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
ERF_HUMAN	ERF	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
CARF_HUMAN	CDKN2AIP	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
ETV3_HUMAN	ETV3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CASA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phosphorylation pattern of human alphas1-casein is markedlydifferent from the ruminant species."; Sorensen E.S., Moller L., Vinther M., Petersen T.E., Rasmussen L.K.; Eur. J. Biochem. 270:3651-3655(2003). Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT SER-33 AND SER-41, LACKOF GLYCOSYLATION, AND MASS SPECTROMETRY.	12919330 [Abstract]
"Analysis of the human casein phosphoproteome by 2-D electrophoresisand MALDI-TOF/TOF MS reveals new phosphoforms."; Poth A.G., Deeth H.C., Alewood P.F., Holland J.W.; J. Proteome Res. 7:5017-5027(2008). Cited for: PROTEIN SEQUENCE OF 28-48, PHOSPHORYLATION AT SER-31; SER-33; SER-41;SER-86; SER-88; SER-89; SER-90 AND SER-91, AND MASS SPECTROMETRY.	18847231 [Abstract]
"On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein."; Kjeldsen F., Savitski M.M., Nielsen M.L., Shi L., Zubarev R.A.; Analyst 132:768-776(2007). Cited for: PROTEIN SEQUENCE OF 27-42 AND 83-98, PHOSPHORYLATION AT SER-33;SER-41; SER-88 AND SER-90, AND MASS SPECTROMETRY.	17646876 [Abstract]