B4GN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B4GN4_HUMAN
• UniProt AC: Q76KP1
• Protein Name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1
• Gene Name: B4GALNT4
• Organism: Homo sapiens (Human).
• Sequence Length: 1039
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
• Protein Description: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans..
• Protein Sequence: MPRLPVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQGRALRQRLGYGRDGEKLTSETDGRGVHAAPSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQVNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGDVQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASRRYYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSPASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARYQGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDEVQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVDVTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGARVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYHSKRGMWSVRSRKGSRTGAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	N-linked_Glycosylation	GAGRLPLNFTHQTPP CCCCCCCCCCCCCCC	37.52	UniProtKB CARBOHYD
159	Phosphorylation	TVKKLAVSPKWKNYG HHHHHCCCHHHHHHC	18.37	-
161	Ubiquitination	KKLAVSPKWKNYGLR HHHCCCHHHHHHCEE	64.39	29967540
163	Acetylation	LAVSPKWKNYGLRIF HCCCHHHHHHCEEEE	46.55	7677797
239	Phosphorylation	KPRRLMASRRYYFEL CCHHHHHHHHHHHHH	11.88	27251275
390	Phosphorylation	ETDNKCFYRESPLYL EECCCCEECCCCCHH	23.96	-
396	Phosphorylation	FYRESPLYLERFGFY EECCCCCHHHHHCHH	15.20	22817900
405	Phosphorylation	ERFGFYKYMKMDKEE HHHCHHHEEECCHHC	7.21	-
616	Phosphorylation	PAAPTVDSNLSSEAR CCCCCCCCCCCCCCC	35.02	20044836
619	Phosphorylation	PTVDSNLSSEARPVT CCCCCCCCCCCCCCC	30.31	20044836
620	Phosphorylation	TVDSNLSSEARPVTS CCCCCCCCCCCCCCC	38.14	22210691
947	Phosphorylation	APVVMRLSCGSSPRD HEEEEEECCCCCCCC	13.18	28348404
1016	Phosphorylation	RLRLRNFYHHYHSKR EHHHHHHHHHCCCCC	7.40	22817900
1019	Phosphorylation	LRNFYHHYHSKRGMW HHHHHHHCCCCCCCE	8.42	22817900
1021	Phosphorylation	NFYHHYHSKRGMWSV HHHHHCCCCCCCEEC	19.51	29759185
1027	Phosphorylation	HSKRGMWSVRSRKGS CCCCCCEECCCCCCC	9.96	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B4GN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B4GN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B4GN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of B4GN4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.