ACVL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACVL1_HUMAN
• UniProt AC: P37023
• Protein Name: Serine/threonine-protein kinase receptor R3
• Gene Name: ACVRL1
• Organism: Homo sapiens (Human).
• Sequence Length: 503
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well..
• Protein Sequence: MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MTLGSPRKGLLM ---CCCCCHHHHHHH	25.33	20562096
98	N-linked_Glycosylation	DSHLCNHNVSLVLEA CHHHCCCCEEEEEEE	15.87	UniProtKB CARBOHYD
155	Phosphorylation	EKQRGLHSELGESSL HHHCCCCCCCCCCCE	39.29	23403867
160	Phosphorylation	LHSELGESSLILKAS CCCCCCCCCEEEEHH	28.75	26657352
161	Phosphorylation	HSELGESSLILKASE CCCCCCCCEEEEHHH	18.35	23403867
375	Phosphorylation	PRVGTKRYMAPEVLD CCCCCCEECCHHHHC	10.13	71763
412	Phosphorylation	LWEIARRTIVNGIVE HHHHHHHHHHHCHHC	24.59	24719451
421	Phosphorylation	VNGIVEDYRPPFYDV HHCHHCCCCCCCCCC	16.12	119601
439	Acetylation	DPSFEDMKKVVCVDQ CCCHHHHCEEEEECC	55.53	7366015
440	Acetylation	PSFEDMKKVVCVDQQ CCHHHHCEEEEECCC	33.01	7366025
481	Phosphorylation	PNPSARLTALRIKKT CCHHHHHHHHHHHHH	20.35	24719451
495	Phosphorylation	TLQKISNSPEKPKVI HHHHHHCCCCCCCCC	27.87	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACVL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACVL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACVL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGFB1_HUMAN	TGFB1	physical	10716993
T22D1_HUMAN	TSC22D1	physical	21791611
IGSF1_HUMAN	IGSF1	physical	11266516
HS90A_HUMAN	HSP90AA1	physical	21465483
BAMBI_HUMAN	BAMBI	physical	19758997
EGLN_HUMAN	ENG	physical	15702480
PEG10_HUMAN	PEG10	physical	15611116
NR1H2_HUMAN	NR1H2	physical	12393874
CSK2B_HUMAN	CSNK2B	physical	19592636
FKB1A_HUMAN	FKBP1A	physical	19592636
SMAD1_HUMAN	SMAD1	physical	19592636
TGFB1_HUMAN	TGFB1	physical	8242742
INHBA_HUMAN	INHBA	physical	8242742
TGFR1_HUMAN	TGFBR1	physical	8242742
SCMC1_HUMAN	SLC25A24	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.