FBXL5_HUMAN - dbPTM
FBXL5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBXL5_HUMAN
UniProt AC Q9UKA1
Protein Name F-box/LRR-repeat protein 5
Gene Name FBXL5
Organism Homo sapiens (Human).
Sequence Length 691
Subcellular Localization Cytoplasm, perinuclear region .
Protein Description Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued..
Protein Sequence MAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31UbiquitinationLYCDKLSKTNFSNNN
HHCHHHHHCCCCCCH		58.9027667366
39UbiquitinationTNFSNNNDFRALLQS
CCCCCCHHHHHHHHH		36.2122817900
42UbiquitinationSNNNDFRALLQSLYA
CCCHHHHHHHHHHHH		16.7722817900
45UbiquitinationNDFRALLQSLYATFK
HHHHHHHHHHHHHHH		32.0422817900
58UbiquitinationFKEFKMHEQIENEYI
HHHHHHHHHHHHHHH		50.1622817900
61UbiquitinationFKMHEQIENEYIIGL
HHHHHHHHHHHHHHH		43.6422817900
64UbiquitinationHEQIENEYIIGLLQQ
HHHHHHHHHHHHHHH		14.9322817900
75UbiquitinationLLQQRSQTIYNVHSD
HHHHHCCCEEECCCC		27.0322817900
77 (in isoform 2)Ubiquitination-17.9621906983
77UbiquitinationQQRSQTIYNVHSDNK
HHHCCCEEECCCCCH		17.9622817900
78UbiquitinationQRSQTIYNVHSDNKL
HHCCCEEECCCCCHH		22.6022817900
80UbiquitinationSQTIYNVHSDNKLSE
CCCEEECCCCCHHHH		26.2922817900
81UbiquitinationQTIYNVHSDNKLSEM
CCEEECCCCCHHHHH		38.3022817900
83 (in isoform 2)Ubiquitination-50.6221906983
83UbiquitinationIYNVHSDNKLSEMLS
EEECCCCCHHHHHHH		50.6222817900
93UbiquitinationSEMLSLFEKGLKNVK
HHHHHHHHHHHHHHH		52.0529967540
94 (in isoform 1)Ubiquitination-63.3121906983
94UbiquitinationEMLSLFEKGLKNVKN
HHHHHHHHHHHHHHH		63.3121906983
97UbiquitinationSLFEKGLKNVKNEYE
HHHHHHHHHHHHHHH		69.2522817900
100UbiquitinationEKGLKNVKNEYEQLN
HHHHHHHHHHHHHHH		54.1521906983
100 (in isoform 1)Ubiquitination-54.1521906983
103PhosphorylationLKNVKNEYEQLNYAK
HHHHHHHHHHHHHHH		20.5418452278
108PhosphorylationNEYEQLNYAKQLKER
HHHHHHHHHHHHHHH		24.6218452278
110UbiquitinationYEQLNYAKQLKERLE
HHHHHHHHHHHHHHH		45.8929967540
119UbiquitinationLKERLEAFTRDFLPH
HHHHHHHHHHHHHHH		4.1427667366
136UbiquitinationEEEEVFQPMLMEYFT
HHHHHHHHHHHHHCC		13.3527667366
145UbiquitinationLMEYFTYEELKDIKK
HHHHCCHHHHHHHHH		54.5233845483
153UbiquitinationELKDIKKKVIAQHCS
HHHHHHHHHHHHHCC		33.5929967540
155UbiquitinationKDIKKKVIAQHCSQK
HHHHHHHHHHHCCHH		4.1327667366
162UbiquitinationIAQHCSQKDTAELLR
HHHHCCHHHHHHHHH		40.5333845483
168UbiquitinationQKDTAELLRGLSLWN
HHHHHHHHHHHHHHC		2.8429967540
172UbiquitinationAELLRGLSLWNHAEE
HHHHHHHHHHCHHHH		33.8827667366
174UbiquitinationLLRGLSLWNHAEERQ
HHHHHHHHCHHHHHH		7.3827667366
185UbiquitinationEERQKFFKYSVDEKS
HHHHHHHCCCCCCCC		39.4829967540
187PhosphorylationRQKFFKYSVDEKSDK
HHHHHCCCCCCCCCC		24.5528348404
191UbiquitinationFKYSVDEKSDKEAEV
HCCCCCCCCCCCCCC		60.5327667366
204UbiquitinationEVSEHSTGITHLPPE
CCCCCCCCCCCCCHH		26.3022817900
207UbiquitinationEHSTGITHLPPEVML
CCCCCCCCCCHHHHH		34.1222817900
221UbiquitinationLSIFSYLNPQELCRC
HHHHHHCCHHHHHHC		28.1622817900
223UbiquitinationIFSYLNPQELCRCSQ
HHHHCCHHHHHHCHH		56.0429967540
224UbiquitinationFSYLNPQELCRCSQV
HHHCCHHHHHHCHHC		51.6122817900
239UbiquitinationSMKWSQLTKTGSLWK
CHHHHHHHCCCCHHH		20.9429967540
240UbiquitinationMKWSQLTKTGSLWKH
HHHHHHHCCCCHHHH		60.5222817900
243UbiquitinationSQLTKTGSLWKHLYP
HHHHCCCCHHHHCCC		35.9722817900
257UbiquitinationPVHWARGDWYSGPAT
CEECCCCCCCCCCCC		35.2722817900
259 (in isoform 2)Ubiquitination-14.4321906983
259UbiquitinationHWARGDWYSGPATEL
ECCCCCCCCCCCCCC		14.4322817900
260UbiquitinationWARGDWYSGPATELD
CCCCCCCCCCCCCCC		33.7622817900
262UbiquitinationRGDWYSGPATELDTE
CCCCCCCCCCCCCCC		30.0222817900
275UbiquitinationTEPDDEWVKNRKDES
CCCCCHHHHCCCHHC		3.5622817900
276UbiquitinationEPDDEWVKNRKDESR
CCCCHHHHCCCHHCC		52.7021906983
276 (in isoform 1)Ubiquitination-52.7021906983
278UbiquitinationDDEWVKNRKDESRAF
CCHHHHCCCHHCCHH		41.9322817900
279UbiquitinationDEWVKNRKDESRAFH
CHHHHCCCHHCCHHH		75.2122817900
330PhosphorylationNVLPYVGTSVKTLVL
HHHHHCCCCHHHHHH		21.94-
331UbiquitinationVLPYVGTSVKTLVLA
HHHHCCCCHHHHHHH		18.7122817900
348UbiquitinationSAVSSKMVRQILELC
HHHCHHHHHHHHHHC		4.7222817900
367UbiquitinationHLDLTQTDISDSAFD
CCCCCCCCCCCCCHH		28.6922817900
384UbiquitinationSWLGCCQSLRHLDLS
HHHHHHHHCCCCCCC		17.2922817900
386UbiquitinationLGCCQSLRHLDLSGC
HHHHHHCCCCCCCCC		33.3022817900
386 (in isoform 2)Ubiquitination-33.3021906983
402UbiquitinationKITDVALEKISRALG
HHHHHHHHHHHHHHC		38.3122817900
403UbiquitinationITDVALEKISRALGI
HHHHHHHHHHHHHCH		47.0022817900
403 (in isoform 1)Ubiquitination-47.0021906983
408UbiquitinationLEKISRALGILTSHQ
HHHHHHHHCHHHHCC		4.2129967540
415UbiquitinationLGILTSHQSGFLKTS
HCHHHHCCCCCCCCC		45.0429967540
417UbiquitinationILTSHQSGFLKTSTS
HHHHCCCCCCCCCCC		25.9029967540
420UbiquitinationSHQSGFLKTSTSKIT
HCCCCCCCCCCCCCC		37.86-
424UbiquitinationGFLKTSTSKITSTAW
CCCCCCCCCCCCCCC		23.1029967540
425UbiquitinationFLKTSTSKITSTAWK
CCCCCCCCCCCCCCC		50.5229967540
431UbiquitinationSKITSTAWKNKDITM
CCCCCCCCCCCCCCC		12.5829967540
432UbiquitinationKITSTAWKNKDITMQ
CCCCCCCCCCCCCCH		52.2129967540
433UbiquitinationITSTAWKNKDITMQS
CCCCCCCCCCCCCHH		36.2129967540
434UbiquitinationTSTAWKNKDITMQST
CCCCCCCCCCCCHHC		46.9429967540
441UbiquitinationKDITMQSTKQYACLH
CCCCCHHCCCEEHHH		12.7929967540
442UbiquitinationDITMQSTKQYACLHD
CCCCHHCCCEEHHHH		46.7029967540
510UbiquitinationSLCVMETASNFSCST
HHEEEEECCCCEECC		6.8127667366
527UbiquitinationCFSKDIVGLRTSVCW
CCCCCCCCCCCHHHH		15.1327667366
546UbiquitinationASPAFAYCGHSFCCT
CCCCHHCCCCCEEHH		3.3827667366
563UbiquitinationALRTMSSLPESSAMC
HHHHHHCCCCCHHHH		4.2327667366
565UbiquitinationRTMSSLPESSAMCRK
HHHHCCCCCHHHHHH		63.7227667366
566PhosphorylationTMSSLPESSAMCRKA
HHHCCCCCHHHHHHH		22.81-
567PhosphorylationMSSLPESSAMCRKAA
HHCCCCCHHHHHHHH		20.54-
581UbiquitinationARTRLPRGKDLIYFG
HHHCCCCCCCEEEEC		26.3727667366
582UbiquitinationRTRLPRGKDLIYFGS
HHCCCCCCCEEEECC		51.1227667366
591UbiquitinationLIYFGSEKSDQETGR
EEEECCCCCCCCCCC		62.11-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBXL5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBXL5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBXL5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCTN1_HUMANDCTN1physical
17532294
ACOC_HUMANACO1physical
19762596
IREB2_HUMANIREB2physical
19762596
IREB2_HUMANIREB2physical
19762597
CUL1_HUMANCUL1physical
19762597
RBX1_HUMANRBX1physical
19762597
SKP1_HUMANSKP1physical
19762597
BTG1_HUMANBTG1physical
22975506
ORC4_HUMANORC4physical
21988832
MIP18_HUMANFAM96Bphysical
24035498
MMS19_HUMANMMS19physical
24035498
MUS81_HUMANMUS81physical
24035498
CUL1_HUMANCUL1physical
22268729
SNAI1_HUMANSNAI1physical
24157836
CUL1_HUMANCUL1physical
24157836
RBX1_HUMANRBX1physical
24157836
SKP1_HUMANSKP1physical
24157836
CUL1_HUMANCUL1physical
24778179
SKP1_HUMANSKP1physical
24778179
ACOC_HUMANACO1physical
24778179
IREB2_HUMANIREB2physical
24778179
HERC2_HUMANHERC2physical
24778179
FBXL5_HUMANFBXL5physical
24867096
CUL1_HUMANCUL1physical
25249620
SOSB1_HUMANNABP2physical
25249620
SKP1_HUMANSKP1physical
21516116
SNAI1_HUMANSNAI1physical
25832584
GDIR2_HUMANARHGDIBphysical
27383304
SKP1_HUMANSKP1physical
27383304
CUL1_HUMANCUL1physical
27383304
NEUL4_HUMANNEURL4physical
28514442
HERC2_HUMANHERC2physical
28514442
ZN106_HUMANZNF106physical
28514442
CUL1_HUMANCUL1physical
28514442
ECI2_HUMANECI2physical
28514442
MA7D1_HUMANMAP7D1physical
28514442
CSN2_HUMANCOPS2physical
28514442
SKP1_HUMANSKP1physical
28514442
APBP2_HUMANAPPBP2physical
28514442
CENPF_HUMANCENPFphysical
28514442
CSN6_HUMANCOPS6physical
28514442
ARI1_HUMANARIH1physical
28514442
TTC9C_HUMANTTC9Cphysical
28514442
KLDC3_HUMANKLHDC3physical
28514442
CSN3_HUMANCOPS3physical
28514442
ACTBL_HUMANACTBL2physical
28514442
MMS19_HUMANMMS19physical
28514442
CSN5_HUMANCOPS5physical
28514442
CTNA2_HUMANCTNNA2physical
28514442
GRAN_HUMANGCAphysical
28514442
MIP18_HUMANFAM96Bphysical
28514442
CIAO1_HUMANCIAO1physical
28514442
ACTB_HUMANACTBphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBXL5_HUMAN

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Related Literatures of Post-Translational Modification

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