ACOC_HUMAN - dbPTM
ACOC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACOC_HUMAN
UniProt AC P21399
Protein Name Cytoplasmic aconitate hydratase
Gene Name ACO1
Organism Homo sapiens (Human).
Sequence Length 889
Subcellular Localization Cytoplasm.
Protein Description Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate..
Protein Sequence MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNPFAHLA
------CCCCCHHCC		53.8928857561
20UbiquitinationDPVQPGKKFFNLNKL
CCCCCCCCCCCCCCC		62.19-
26UbiquitinationKKFFNLNKLEDSRYG
CCCCCCCCCCCCCCC		57.32-
30PhosphorylationNLNKLEDSRYGRLPF
CCCCCCCCCCCCCCH		20.3028857561
32PhosphorylationNKLEDSRYGRLPFSI
CCCCCCCCCCCCHHH		15.5624275569
562-HydroxyisobutyrylationNCDEFLVKKQDIENI
CCHHHEECHHHHHHH		47.03-
57UbiquitinationCDEFLVKKQDIENIL
CHHHEECHHHHHHHH		45.80-
79UbiquitinationKNIEVPFKPARVILQ
CCCCCCCCCCEEEEE		31.5321890473
105UbiquitinationAAMRDAVKKLGGDPE
HHHHHHHHHHCCCHH		43.9621906983
106UbiquitinationAMRDAVKKLGGDPEK
HHHHHHHHHCCCHHH		45.8521890473
138PhosphorylationDFNRRADSLQKNQDL
ECCCCHHHHHHCCCC		31.5426699800
141AcetylationRRADSLQKNQDLEFE
CCHHHHHHCCCCHHH		62.9723236377
141UbiquitinationRRADSLQKNQDLEFE
CCHHHHHHCCCCHHH		62.9721890473
158UbiquitinationRERFEFLKWGSQAFH
HHHHHHHHHCHHHHC		55.63-
184PhosphorylationIHQVNLEYLARVVFD
EEECCHHHHEEEEEC		14.61-
250UbiquitinationIGYRLMGKPHPLVTS
HHHHHCCCCCCCCCC		26.62-
258PhosphorylationPHPLVTSTDIVLTIT
CCCCCCCCHHHHHHH		22.00-
289PhosphorylationGPGVAQLSIADRATI
CCCCEEEEHHCHHHH		12.0324719451
318PhosphorylationPVDEVSITYLVQTGR
ECCEEEEEEEEECCC		11.87-
332PhosphorylationRDEEKLKYIKKYLQA
CCHHHHHHHHHHHHH		28.5426074081
335UbiquitinationEKLKYIKKYLQAVGM
HHHHHHHHHHHHHCC		41.45-
3352-HydroxyisobutyrylationEKLKYIKKYLQAVGM
HHHHHHHHHHHHHCC		41.45-
336PhosphorylationKLKYIKKYLQAVGMF
HHHHHHHHHHHHCCC		10.0725884760
350PhosphorylationFRDFNDPSQDPDFTQ
CCCCCCCCCCCCCCE		50.5130175587
379AcetylationGPKRPQDKVAVSDMK
CCCCCCCCEEHHHHH		27.1825953088
383PhosphorylationPQDKVAVSDMKKDFE
CCCCEEHHHHHHHHH		23.4222817900
3862-HydroxyisobutyrylationKVAVSDMKKDFESCL
CEEHHHHHHHHHHHH		54.93-
386UbiquitinationKVAVSDMKKDFESCL
CEEHHHHHHHHHHHH		54.9321906983
3872-HydroxyisobutyrylationVAVSDMKKDFESCLG
EEHHHHHHHHHHHHC		62.10-
387UbiquitinationVAVSDMKKDFESCLG
EEHHHHHHHHHHHHC		62.10-
396UbiquitinationFESCLGAKQGFKGFQ
HHHHHCCCCCCCCEE		49.51-
400UbiquitinationLGAKQGFKGFQVAPE
HCCCCCCCCEEECCC		66.69-
455UbiquitinationGAGLLAKKAVDAGLN
CHHHHHHHHHHCCCC		48.30-
466PhosphorylationAGLNVMPYIKTSLSP
CCCCCCCEEECCCCC		9.2820068231
533PhosphorylationLVAVGVLSGNRNFEG
EEEEEEECCCCCCCC		31.4523312004
572UbiquitinationTIRIDFEKEPLGVNA
EEEEEECCCCCCCCC		65.7021890473
5722-HydroxyisobutyrylationTIRIDFEKEPLGVNA
EEEEEECCCCCCCCC		65.70-
580UbiquitinationEPLGVNAKGQQVFLK
CCCCCCCCCCEEEEE		52.6421890473
587UbiquitinationKGQQVFLKDIWPTRD
CCCEEEEECCCCCHH		35.39-
610UbiquitinationYVIPGMFKEVYQKIE
HCCCCHHHHHHHHHH		37.0621890473
615UbiquitinationMFKEVYQKIETVNES
HHHHHHHHHHHHHHH		25.4821906983
622PhosphorylationKIETVNESWNALATP
HHHHHHHHHHCCCCC		22.04-
628PhosphorylationESWNALATPSDKLFF
HHHHCCCCCCCCEEE		24.958041788
630PhosphorylationWNALATPSDKLFFWN
HHCCCCCCCCEEEEC		42.9220068231
632UbiquitinationALATPSDKLFFWNSK
CCCCCCCCEEEECCC		52.0821906983
638PhosphorylationDKLFFWNSKSTYIKS
CCEEEECCCCCCCCC		20.6929514088
639UbiquitinationKLFFWNSKSTYIKSP
CEEEECCCCCCCCCC		43.5321890473
639UbiquitinationKLFFWNSKSTYIKSP
CEEEECCCCCCCCCC		43.5321890473
640PhosphorylationLFFWNSKSTYIKSPP
EEEECCCCCCCCCCC		26.6828857561
644UbiquitinationNSKSTYIKSPPFFEN
CCCCCCCCCCCCHHC		46.6321906983
645PhosphorylationSKSTYIKSPPFFENL
CCCCCCCCCCCHHCC		28.3924275569
702PhosphorylationYLTNRGLTPREFNSY
HHHCCCCCHHHCCCC		24.1124719451
711PhosphorylationREFNSYGSRRGNDAV
HHCCCCCCCCCCCCC		15.5722817900
713MethylationFNSYGSRRGNDAVMA
CCCCCCCCCCCCCCC		50.3881424313
719SulfoxidationRRGNDAVMARGTFAN
CCCCCCCCCCCHHHH		1.9530846556
721MethylationGNDAVMARGTFANIR
CCCCCCCCCHHHHHH		26.9682797163
736UbiquitinationLLNRFLNKQAPQTIH
HHHHHHCCCCCCEEE		50.4021890473
759PhosphorylationVFDAAERYQQAGLPL
HHHHHHHHHHCCCCE		9.1122817900
772UbiquitinationPLIVLAGKEYGAGSS
CEEEECCCCCCCCCC		42.0021890473
778PhosphorylationGKEYGAGSSRDWAAK
CCCCCCCCCCHHHHC		22.9726437602
785UbiquitinationSSRDWAAKGPFLLGI
CCCHHHHCCHHHHCH		60.4121890473
799PhosphorylationIKAVLAESYERIHRS
HHHHHHHHHHHHHHH		27.0420860994
800PhosphorylationKAVLAESYERIHRSN
HHHHHHHHHHHHHHC		10.7520860994
806PhosphorylationSYERIHRSNLVGMGV
HHHHHHHHCCCCCEE		21.98-
844UbiquitinationIIIPENLKPQMKVQV
EEECCCCCCCEEEEE		44.802190698
852UbiquitinationPQMKVQVKLDTGKTF
CCEEEEEEECCCCEE		24.45-
852AcetylationPQMKVQVKLDTGKTF
CCEEEEEEECCCCEE		24.4525953088
857UbiquitinationQVKLDTGKTFQAVMR
EEEECCCCEEEEEEE		48.54-
8572-HydroxyisobutyrylationQVKLDTGKTFQAVMR
EEEECCCCEEEEEEE		48.54-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
138SPhosphorylationKinasePKCAP04409
PSP
138SPhosphorylationKinasePRKCAP17252
GPS
711SPhosphorylationKinasePKCAP04409
PSP
711SPhosphorylationKinasePRKCAP17252
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACOC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACOC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FBXL5_HUMANFBXL5physical
19762596
A4_HUMANAPPphysical
21832049
C10_HUMANC12orf57physical
22939629
PYRG1_HUMANCTPS1physical
22863883
PSMG1_HUMANPSMG1physical
22863883
TXD17_HUMANTXNDC17physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACOC_HUMAN

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Related Literatures of Post-Translational Modification

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