F264_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F264_HUMAN
• UniProt AC: Q16877
• Protein Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
• Gene Name: PFKFB4
• Organism: Homo sapiens (Human).
• Sequence Length: 469
• Protein Description: Synthesis and degradation of fructose 2,6-bisphosphate..
• Protein Sequence: MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPRELTQN -----CCCHHHHCCC	24.16	22199227
8	Phosphorylation	MASPRELTQNPLKKI CCCHHHHCCCCCHHC	22.88	29514088
13	Ubiquitination	ELTQNPLKKIWMPYS HHCCCCCHHCCCCCC	43.39	-
87	Ubiquitination	RDVVKTYKSFEFFLP HHHHHHHCEEEEECC	54.63	-
101	Ubiquitination	PDNEEGLKIRKQCAL CCCHHHHHHHHHHHH	51.85	-
104	Ubiquitination	EEGLKIRKQCALAAL HHHHHHHHHHHHHHH	53.88	-
119	Phosphorylation	RDVRRFLSEEGGHVA HHHHHHHHHCCCEEE	30.78	-
131	Phosphorylation	HVAVFDATNTTRERR EEEEEECCCCCCCCE	34.64	24275569
150	Phosphorylation	NFGEQNGYKTFFVES ECCCCCCEEEEEEEE	17.88	22817900
176	Phosphorylation	IVQVKLGSPDYVNRD EEEEECCCCCCCCCC	25.65	21815630
184	Phosphorylation	PDYVNRDSDEATEDF CCCCCCCCHHHHHHH	33.83	28348404
214	Phosphorylation	EDLDRDLSYIKIMDV CHHHCCCCEEEEEEC	29.15	24719451
265	Ubiquitination	GESELNLKGRIGGDP CCCEECCCCCCCCCC	45.10	-
275	Phosphorylation	IGGDPGLSPRGREFA CCCCCCCCHHHHHHH	20.61	30266825
283	Ubiquitination	PRGREFAKSLAQFIS HHHHHHHHHHHHHHC	51.85	-
295	Ubiquitination	FISDQNIKDLKVWTS HHCCCCHHHHHHHHH	65.64	-
305	Ubiquitination	KVWTSQMKRTIQTAE HHHHHHHHHHHHHHH	38.46	-
362	Ubiquitination	KYRYRYPKGESYEDL CCCCCCCCCCCHHHH	67.39	-
444	Phosphorylation	LNVAAVNTHRDRPQN EEEEEHHCCCCCCCC	16.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
444	T	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F264_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F264_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F264_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.