ACHA4_HUMAN - dbPTM
ACHA4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACHA4_HUMAN
UniProt AC P43681
Protein Name Neuronal acetylcholine receptor subunit alpha-4
Gene Name CHRNA4
Organism Homo sapiens (Human).
Sequence Length 627
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein. Cell membrane
Multi-pass membrane protein. Cell membrane
Lipid-anchor.
Protein Description After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions..
Protein Sequence MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10MethylationLGGPGAPRLLPPLLL
CCCCCHHHCHHHHHH		48.6118567405
25MethylationLLGTGLLRASSHVET
HHHHCHHHHCCCHHH		37.1518567415
33MethylationASSHVETRAHAEERL
HCCCHHHHHHHHHHH		15.7418567425
46PhosphorylationRLLKKLFSGYNKWSR
HHHHHHHCCCCCCCC		51.2924961811
57N-linked_GlycosylationKWSRPVANISDVVLV
CCCCCCCCCCHHHHH		34.23UniProtKB CARBOHYD
84PhosphorylationDEKNQMMTTNVWVKQ
CHHCCEEEEEEEECC		15.1830619164
85PhosphorylationEKNQMMTTNVWVKQE
HHCCEEEEEEEECCC		15.1830619164
107N-linked_GlycosylationWDPADYENVTSIRIP
CCHHHCCCCCEEECC		35.82UniProtKB CARBOHYD
115PhosphorylationVTSIRIPSELIWRPD
CCEEECCHHHCCCCC		42.5427794612
136PhosphorylationADGDFAVTHLTKAHL
CCCCEEEEEECEEEE		14.0326437602
174N-linked_GlycosylationFFPFDQQNCTMKFGS
EEECCCCCCEEEECE		20.00UniProtKB CARBOHYD
196PhosphorylationIDLVNMHSRVDQLDF
EEEEECCCCCCCCCH		24.19-
271S-palmitoylationVFYLPSECGEKITLC
HHHCCCCCCHHHHHH		11.35-
334PhosphorylationVLNVHHRSPRTHTMP
HHCCCCCCCCCCCCC		17.8726074081
337PhosphorylationVHHRSPRTHTMPTWV
CCCCCCCCCCCCHHH		25.6926074081
339PhosphorylationHRSPRTHTMPTWVRR
CCCCCCCCCCHHHHH		25.0026074081
342PhosphorylationPRTHTMPTWVRRVFL
CCCCCCCHHHHHHHH		26.2726074081
362PhosphorylationLLLMKRPSVVKDNCR
HHHHCCCHHHHHHHH		43.5022817900
424PhosphorylationEPGPSCKSPSDQLPP
CCCCCCCCHHHCCCC		33.68-
465PhosphorylationPGLAKARSLSVQHMS
CCHHHHHHCEEEECC		29.8323532336
467PhosphorylationLAKARSLSVQHMSSP
HHHHHHCEEEECCCC		22.4522817900
488PhosphorylationGVRCRSRSIQYCVPR
CEEEECCEEEEEEEC		18.45-
538PhosphorylationCTCKKEPSSVSPSAT
CEECCCCCCCCCCCE		44.45-
539PhosphorylationTCKKEPSSVSPSATV
EECCCCCCCCCCCEE		37.01-
541PhosphorylationKKEPSSVSPSATVKT
CCCCCCCCCCCEEEE		18.32-
543PhosphorylationEPSSVSPSATVKTRS
CCCCCCCCCEEEECC		29.12-
545PhosphorylationSSVSPSATVKTRSTK
CCCCCCCEEEECCCC		27.20-
550PhosphorylationSATVKTRSTKAPPPH
CCEEEECCCCCCCCC		39.2222817900
561PhosphorylationPPPHLPLSPALTRAV
CCCCCCCCHHHHHHH		13.24-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
362SPhosphorylationKinasePKA-FAMILY-GPS
467SPhosphorylationKinasePKA-FAMILY-GPS
550SPhosphorylationKinasePKC-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACHA4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACHA4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433F_HUMANYWHAHphysical
11352901
UBQL1_MOUSEUbqln1physical
16091357
Drug and Disease Associations
Kegg Disease
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
OMIM Disease
600513Epilepsy, nocturnal frontal lobe, 1 (ENFL1)
Kegg Drug
D00611 Mecamylamine hydrochloride (USP); Inversine (TN)
D00999 Acetylcholine chloride (JP16/USP/INN); Miochol (TN)
D02202 Lobeline hydrochloride (JAN)
D02204 Hexamethonium bromide (JAN/INN); Hexamethonium bromide (TN)
D02364 Lobeline (INN)
D02839 Altinicline maleate (USAN)
D06282 Varenicline tartrate (USAN); Chantix (TN)
D08138 Lobeline sulfate; Smokeless (TN)
D08669 Varenicline (INN)
D08935 Ispronicline (INN/USAN)
D08987 Rivanicline galactarate (USAN)
D09367 Pozanicline (USAN); ABT-089
D09368 Pozanicline tartrate (USAN)
D09382 Sofinicline (USAN)
D09383 Sofinicline benzenesulfonate (USAN)
D10111 Dexmecamylamine (USAN)
D10112 Dexmecamylamine hydrochloride (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACHA4_HUMAN

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Related Literatures of Post-Translational Modification

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