dbPTM

KS6B2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KS6B2_HUMAN
UniProt AC	Q9UBS0
Protein Name	Ribosomal protein S6 kinase beta-2
Gene Name	RPS6KB2
Organism	Homo sapiens (Human).
Sequence Length	482
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Phosphorylates specifically ribosomal protein S6..
Protein Sequence	MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	VFDLDLETEEGSEGE EEEEEECCCCCCCCC	46.78	29743597
15	Phosphorylation	DLETEEGSEGEGEPE EECCCCCCCCCCCCC	45.79	25159151
24	Phosphorylation	GEGEPELSPADACPL CCCCCCCCHHHHCCH	19.17	29743597
45	Phosphorylation	GLEPVGHYEEVELTE CCCCCCCCEEEEEEE	14.09	29978859
51	Phosphorylation	HYEEVELTETSVNVG CCEEEEEEEEEEECC	24.58	29978859
75	Ubiquitination	ELLRVLGKGGYGKVF HHHHHHCCCCCCCEE	45.03	-
80	Ubiquitination	LGKGGYGKVFQVRKV HCCCCCCCEEEEEEE	31.24	-
86	Ubiquitination	GKVFQVRKVQGTNLG CCEEEEEEEECCCHH	39.80	29967540
94	Ubiquitination	VQGTNLGKIYAMKVL EECCCHHHHHHHHHH	35.39	-
96	Phosphorylation	GTNLGKIYAMKVLRK CCCHHHHHHHHHHHH	12.25	-
111	Ubiquitination	AKIVRNAKDTAHTRA CHHHHCCCHHHHHHH	60.19	-
136	Phosphorylation	PFIVELAYAFQTGGK CHHHHHHHHHHCCCE	22.15	-
196	Ubiquitination	GIIYRDLKPENIMLS CCEECCCCHHHEEEC	55.35	-
219	Phosphorylation	DFGLCKESIHEGAVT CCCCCCCCHHCCCCC	18.10	22322096
226	Phosphorylation	SIHEGAVTHTFCGTI CHHCCCCCEEECCCE	18.05	22322096
228	Phosphorylation	HEGAVTHTFCGTIEY HCCCCCEEECCCEEE	15.97	17317726
232	Phosphorylation	VTHTFCGTIEYMAPE CCEEECCCEEECCCH	16.30	-
254	Phosphorylation	NRAVDWWSLGALMYD CCCCCHHHHHHHHHH	16.81	-
266	Phosphorylation	MYDMLTGSPPFTAEN HHHHHHCCCCCCHHH	24.94	-
270	Phosphorylation	LTGSPPFTAENRKKT HHCCCCCCHHHHHHH	38.54	-
276	Acetylation	FTAENRKKTMDKIIR CCHHHHHHHHHHHHC	45.93	7824281
280	Ubiquitination	NRKKTMDKIIRGKLA HHHHHHHHHHCCCCC	29.25	-
285	Ubiquitination	MDKIIRGKLALPPYL HHHHHCCCCCCCCCC	22.27	29967540
356	Phosphorylation	LQSEEDVSQFDTRFT CCCHHHHHHCCCCCC	37.13	17525332
370	Phosphorylation	TRQTPVDSPDDTALS CCCCCCCCCCCCCCC	30.38	11733037
374	Phosphorylation	PVDSPDDTALSESAN CCCCCCCCCCCHHHH	36.56	28348404
377	Phosphorylation	SPDDTALSESANQAF CCCCCCCCHHHHHHH	27.35	28348404
379	Phosphorylation	DDTALSESANQAFLG CCCCCCHHHHHHHHC	29.19	28348404
388	Phosphorylation	NQAFLGFTYVAPSVL HHHHHCCEEECHHHH	18.45	14560963
403	Phosphorylation	DSIKEGFSFQPKLRS HHHHCCCCCCCCCCC	33.55	28555341
407	Ubiquitination	EGFSFQPKLRSPRRL CCCCCCCCCCCCCCC	45.83	29967540
410	Phosphorylation	SFQPKLRSPRRLNSS CCCCCCCCCCCCCCC	32.94	11108720
416	Phosphorylation	RSPRRLNSSPRAPVS CCCCCCCCCCCCCCC	46.43	22617229
417	Phosphorylation	SPRRLNSSPRAPVSP CCCCCCCCCCCCCCC	19.82	22617229
423	Phosphorylation	SSPRAPVSPLKFSPF CCCCCCCCCCCCCCC	24.37	23401153
436	Phosphorylation	PFEGFRPSPSLPEPT CCCCCCCCCCCCCCC	23.90	22210691
438	Phosphorylation	EGFRPSPSLPEPTEL CCCCCCCCCCCCCCC	61.98	22210691
457	Phosphorylation	LLPPPPPSTTAPLPI CCCCCCCCCCCCCCC	44.13	22210691
458	Phosphorylation	LPPPPPSTTAPLPIR CCCCCCCCCCCCCCC	32.52	26434776
459	Phosphorylation	PPPPPSTTAPLPIRP CCCCCCCCCCCCCCC	30.52	22210691
468	Phosphorylation	PLPIRPPSGTKKSKR CCCCCCCCCCCCCCC	62.87	26434776
470	Phosphorylation	PIRPPSGTKKSKRGR CCCCCCCCCCCCCCC	39.37	26434776
473	Phosphorylation	PPSGTKKSKRGRGRP CCCCCCCCCCCCCCC	29.19	14702039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
45	Y	Phosphorylation	Kinase	SRC	P12931	PSP
388	T	Phosphorylation	Kinase	MTOR	P42345	PhosphoELM
473	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
473	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
473	S	Phosphorylation	Kinase	PKCB ISO2	P05771-2	PSP
473	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
473	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
473	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
473	S	Phosphorylation	Kinase	PRKCI	P41743	GPS
473	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
473	S	Phosphorylation	Kinase	PKCZ	Q02956	PSP
473	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
473	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KS6B2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KS6B2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT2B_HUMAN	KAT2B	physical	19961954
EP300_HUMAN	EP300	physical	19961954
STRBP_HUMAN	STRBP	physical	22939629
KPCE_HUMAN	PRKCE	physical	16810323
BRAF_HUMAN	BRAF	physical	16810323
PPAP_HUMAN	ACPP	physical	25324306
ACTS_HUMAN	ACTA1	physical	25324306
ACTG_HUMAN	ACTG1	physical	25324306
AIFM1_HUMAN	AIFM1	physical	25324306
ALBU_HUMAN	ALB	physical	25324306
ALG1_HUMAN	ALG1	physical	25324306
ANKY2_HUMAN	ANKMY2	physical	25324306
ANXA2_HUMAN	ANXA2	physical	25324306
AT1A1_HUMAN	ATP1A1	physical	25324306
ATPA_HUMAN	ATP5A1	physical	25324306
BAG2_HUMAN	BAG2	physical	25324306
BRAF_HUMAN	BRAF	physical	25324306
RTCB_HUMAN	RTCB	physical	25324306
PYR1_HUMAN	CAD	physical	25324306
CAPR1_HUMAN	CAPRIN1	physical	25324306
CAZA1_HUMAN	CAPZA1	physical	25324306
CC124_HUMAN	CCDC124	physical	25324306
TCPB_HUMAN	CCT2	physical	25324306
TCPG_HUMAN	CCT3	physical	25324306
TCPD_HUMAN	CCT4	physical	25324306
TCPE_HUMAN	CCT5	physical	25324306
TCPZ_HUMAN	CCT6A	physical	25324306
TCPH_HUMAN	CCT7	physical	25324306
TCPQ_HUMAN	CCT8	physical	25324306
CDC37_HUMAN	CDC37	physical	25324306
CDC45_HUMAN	CDC45	physical	25324306
COF1_HUMAN	CFL1	physical	25324306
ICLN_HUMAN	CLNS1A	physical	25324306
DDB1_HUMAN	DDB1	physical	25324306
DDX1_HUMAN	DDX1	physical	25324306
DDX17_HUMAN	DDX17	physical	25324306
DDX3X_HUMAN	DDX3X	physical	25324306
DDX5_HUMAN	DDX5	physical	25324306
DDX6_HUMAN	DDX6	physical	25324306
DHX9_HUMAN	DHX9	physical	25324306
DNJA2_HUMAN	DNAJA2	physical	25324306
DNJB1_HUMAN	DNAJB1	physical	25324306
DNJC7_HUMAN	DNAJC7	physical	25324306
DNJA1_HUMAN	DNAJA1	physical	25324306
EF1A1_HUMAN	EEF1A1	physical	25324306
EF1G_HUMAN	EEF1G	physical	25324306
IF2B_HUMAN	EIF2S2	physical	25324306
EIF3B_HUMAN	EIF3B	physical	25324306
EWS_HUMAN	EWSR1	physical	25324306
FA60A_HUMAN	FAM60A	physical	25324306
FKBP5_HUMAN	FKBP5	physical	25324306
FKBP8_HUMAN	FKBP8	physical	25324306
FUS_HUMAN	FUS	physical	25324306
G3BP1_HUMAN	G3BP1	physical	25324306
GDF5_HUMAN	GDF5	physical	25324306
GTF2I_HUMAN	GTF2I	physical	25324306
HAT1_HUMAN	HAT1	physical	25324306
LRC15_HUMAN	LRRC15	physical	25324306
1A02_HUMAN	HLA-A	physical	25324306
1A03_HUMAN	HLA-A	physical	25324306
1A01_HUMAN	HLA-A	physical	25324306
1A26_HUMAN	HLA-A	physical	25324306
ROA1_HUMAN	HNRNPA1	physical	25324306
ROA2_HUMAN	HNRNPA2B1	physical	25324306
HNRPK_HUMAN	HNRNPK	physical	25324306
HNRPM_HUMAN	HNRNPM	physical	25324306
HNRPU_HUMAN	HNRNPU	physical	25324306
HS90A_HUMAN	HSP90AA1	physical	25324306
HS90B_HUMAN	HSP90AB1	physical	25324306
HSP7E_HUMAN	HSPA14	physical	25324306
HS74L_HUMAN	HSPA4L	physical	25324306
GRP78_HUMAN	HSPA5	physical	25324306
HSP76_HUMAN	HSPA6	physical	25324306
HSP7C_HUMAN	HSPA8	physical	25324306
GRP75_HUMAN	HSPA9	physical	25324306
CH60_HUMAN	HSPD1	physical	25324306
HS105_HUMAN	HSPH1	physical	25324306
IF2B1_HUMAN	IGF2BP1	physical	25324306
IPO5_HUMAN	IPO5	physical	25324306
IPO7_HUMAN	IPO7	physical	25324306
IQGA1_HUMAN	IQGAP1	physical	25324306
KIF2A_HUMAN	KIF2A	physical	25324306
KINH_HUMAN	KIF5B	physical	25324306
K2C1_HUMAN	KRT1	physical	25324306
K1C10_HUMAN	KRT10	physical	25324306
K1C13_HUMAN	KRT13	physical	25324306
K1C14_HUMAN	KRT14	physical	25324306
K1C16_HUMAN	KRT16	physical	25324306
K22E_HUMAN	KRT2	physical	25324306
K2C5_HUMAN	KRT5	physical	25324306
K2C6A_HUMAN	KRT6A	physical	25324306
K1C9_HUMAN	KRT9	physical	25324306
LPPRC_HUMAN	LRPPRC	physical	25324306
LTV1_HUMAN	LTV1	physical	25324306
LYSC_HUMAN	LYZ	physical	25324306
MAGD1_HUMAN	MAGED1	physical	25324306
MAGD2_HUMAN	MAGED2	physical	25324306
MCM3_HUMAN	MCM3	physical	25324306
RT22_HUMAN	MRPS22	physical	25324306
MSH6_HUMAN	MSH6	physical	25324306
MYO1C_HUMAN	MYO1C	physical	25324306
NUCL_HUMAN	NCL	physical	25324306
NDK3_HUMAN	NME3	physical	25324306
NONO_HUMAN	NONO	physical	25324306
NPM_HUMAN	NPM1	physical	25324306
NUDC_HUMAN	NUDC	physical	25324306
PCBP1_HUMAN	PCBP1	physical	25324306
PIMT_HUMAN	PCMT1	physical	25324306
PCNA_HUMAN	PCNA	physical	25324306
PDCD4_HUMAN	PDCD4	physical	25324306
SERA_HUMAN	PHGDH	physical	25324306
PDIP3_HUMAN	POLDIP3	physical	25324306
PPM1G_HUMAN	PPM1G	physical	25324306
PP2AA_HUMAN	PPP2CA	physical	25324306
2AAA_HUMAN	PPP2R1A	physical	25324306
2ABA_HUMAN	PPP2R2A	physical	25324306
PP6R1_HUMAN	PPP6R1	physical	25324306
PP6R3_HUMAN	PPP6R3	physical	25324306
NPY4R_HUMAN	NPY4R	physical	25324306
PRDX1_HUMAN	PRDX1	physical	25324306
ANM1_HUMAN	PRMT1	physical	25324306
TRY3_HUMAN	PRSS3	physical	25324306
PRS4_HUMAN	PSMC1	physical	25324306
PRS7_HUMAN	PSMC2	physical	25324306
PRS6A_HUMAN	PSMC3	physical	25324306
PSMD3_HUMAN	PSMD3	physical	25324306
PSPC1_HUMAN	PSPC1	physical	25324306
TEBP_HUMAN	PTGES3	physical	25324306
RBBP7_HUMAN	RBBP7	physical	25324306
RL13_HUMAN	RPL13	physical	25324306
RL14_HUMAN	RPL14	physical	25324306
RL17_HUMAN	RPL17	physical	25324306
RL19_HUMAN	RPL19	physical	25324306
RL22L_HUMAN	RPL22L1	physical	25324306
RL23A_HUMAN	RPL23A	physical	25324306
RL24_HUMAN	RPL24	physical	25324306
RL26_HUMAN	RPL26	physical	25324306
RL8_HUMAN	RPL8	physical	25324306
RPN1_HUMAN	RPN1	physical	25324306
RS14_HUMAN	RPS14	physical	25324306
RS17_HUMAN	RPS17	physical	25324306
RS18_HUMAN	RPS18	physical	25324306
RS19_HUMAN	RPS19	physical	25324306
RS2_HUMAN	RPS2	physical	25324306
RS25_HUMAN	RPS25	physical	25324306
RS3_HUMAN	RPS3	physical	25324306
RS3A_HUMAN	RPS3A	physical	25324306
RS4X_HUMAN	RPS4X	physical	25324306
RS5_HUMAN	RPS5	physical	25324306
RS6_HUMAN	RPS6	physical	25324306
RS7_HUMAN	RPS7	physical	25324306
RS8_HUMAN	RPS8	physical	25324306
RUVB1_HUMAN	RUVBL1	physical	25324306
RUVB2_HUMAN	RUVBL2	physical	25324306
PAIRB_HUMAN	SERBP1	physical	25324306
SFPQ_HUMAN	SFPQ	physical	25324306
SHRM3_HUMAN	SHROOM3	physical	25324306
ADT2_HUMAN	SLC25A5	physical	25324306
4F2_HUMAN	SLC3A2	physical	25324306
RSMB_HUMAN	SNRPB	physical	25324306
SSRA_HUMAN	SSR1	physical	25324306
CHIP_HUMAN	STUB1	physical	25324306
SGT1_HUMAN	SUGT1	physical	25324306
RBP56_HUMAN	TAF15	physical	25324306
TCPA_HUMAN	TCP1	physical	25324306
TFAM_HUMAN	TFAM	physical	25324306
TIM50_HUMAN	TIMM50	physical	25324306
TBA1B_HUMAN	TUBA1B	physical	25324306
TBA1C_HUMAN	TUBA1C	physical	25324306
TBB5_HUMAN	TUBB	physical	25324306
TBB4B_HUMAN	TUBB4B	physical	25324306
TBB3_HUMAN	TUBB3	physical	25324306
TBB6_HUMAN	TUBB6	physical	25324306
EFTU_HUMAN	TUFM	physical	25324306
UBP7_HUMAN	USP7	physical	25324306
USP9X_HUMAN	USP9X	physical	25324306
BUD23_HUMAN	WBSCR22	physical	25324306
WRIP1_HUMAN	WRNIP1	physical	25324306
XRCC5_HUMAN	XRCC5	physical	25324306
YBOX1_HUMAN	YBX1	physical	25324306
YTHD2_HUMAN	YTHDF2	physical	25324306
1433F_HUMAN	YWHAH	physical	25324306
1433T_HUMAN	YWHAQ	physical	25324306
RUXE_HUMAN	SNRPE	physical	25324306

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KS6B2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.	17081983 [Abstract]