dbPTM

MINK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MINK1_HUMAN
UniProt AC	Q8N4C8
Protein Name	Misshapen-like kinase 1
Gene Name	MINK1 {ECO:0000312\|HGNC:HGNC:17565}
Organism	Homo sapiens (Human).
Sequence Length	1332
Subcellular Localization	Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite. Isoform 4: Golgi apparatus.
Protein Description	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration..
Protein Sequence	MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GDPAPARSLDDIDLS CCCCCCCCCCCCCHH	37.95	24719451
16	Phosphorylation	SLDDIDLSALRDPAG CCCCCCHHHHCCCCC	22.85	20068231
16 (in isoform 4)	Phosphorylation	-	22.85	-
35	Phosphorylation	VEVVGNGTYGQVYKG EEEECCCCCCEEECC	28.60	18452278
35 (in isoform 4)	Phosphorylation	-	28.60	-
36	Phosphorylation	EVVGNGTYGQVYKGR EEECCCCCCEEECCC	13.63	25884760
40	Phosphorylation	NGTYGQVYKGRHVKT CCCCCEEECCCCCCC	10.39	18452278
40 (in isoform 4)	Phosphorylation	-	10.39	-
46	Ubiquitination	VYKGRHVKTGQLAAI EECCCCCCCCCEEEE	40.59	29967540
54	Ubiquitination	TGQLAAIKVMDVTED CCCEEEEEEECCCCC	27.12	-
59	Phosphorylation	AIKVMDVTEDEEEEI EEEEECCCCCCHHHH	33.19	29514088
84	Phosphorylation	SHHRNIATYYGAFIK HCHHCHHHHEEEEEE	17.30	24076635
85	Phosphorylation	HHRNIATYYGAFIKK CHHCHHHHEEEEEEC	7.29	29083192
86	Phosphorylation	HRNIATYYGAFIKKS HHCHHHHEEEEEECC	9.53	25839225
100	Ubiquitination	SPPGNDDQLWLVMEF CCCCCHHHHEEEEEC	37.08	30230243
138	Phosphorylation	AYICREILRGLAHLH HHHHHHHHHHHHHHH	2.81	32142685
155	Ubiquitination	KVIHRDIKGQNVLLT HHCCCCCCCCEEEEC	59.75	30230243
175	Phosphorylation	KLVDFGVSAQLDRTV EEEEECCEEECCCCC	15.63	30576142
175 (in isoform 4)	Phosphorylation	-	15.63	-
181	Phosphorylation	VSAQLDRTVGRRNTF CEEECCCCCCCCCCC	27.29	30266825
187	Phosphorylation	RTVGRRNTFIGTPYW CCCCCCCCCCCCCCC	18.15	22322096
187 (in isoform 4)	Phosphorylation	-	18.15	-
191	Phosphorylation	RRNTFIGTPYWMAPE CCCCCCCCCCCCCCC	14.37	12507505
193	Phosphorylation	NTFIGTPYWMAPEVI CCCCCCCCCCCCCEE	13.98	12507505
248	Ubiquitination	ALFLIPRNPPPRLKS EEEECCCCCCCCCCC	48.34	30230243
280	Phosphorylation	TYLSRPPTEQLLKFP HHHCCCCHHHHHCCC	38.76	-
299	Ubiquitination	QPTERQVRIQLKDHI CCCCCCHHHHHHHHH	11.55	21963094
303	Ubiquitination	RQVRIQLKDHIDRSR CCHHHHHHHHHHHHH	30.77	30230243
308	Ubiquitination	QLKDHIDRSRKKRGE HHHHHHHHHHHHHCC	37.44	29967540
315	Ubiquitination	RSRKKRGEKEETEYE HHHHHHCCCCCCCCC	62.42	21963094
319	Phosphorylation	KRGEKEETEYEYSGS HHCCCCCCCCCCCCC	44.98	18691976
319 (in isoform 4)	Phosphorylation	-	44.98	-
321	Phosphorylation	GEKEETEYEYSGSEE CCCCCCCCCCCCCCC	27.82	30576142
321 (in isoform 4)	Phosphorylation	-	27.82	-
323	Phosphorylation	KEETEYEYSGSEEED CCCCCCCCCCCCCCC	19.89	26657352
323 (in isoform 4)	Phosphorylation	-	19.89	-
324	Phosphorylation	EETEYEYSGSEEEDD CCCCCCCCCCCCCCC	24.73	18691976
324 (in isoform 4)	Phosphorylation	-	24.73	-
326	Phosphorylation	TEYEYSGSEEEDDSH CCCCCCCCCCCCCCC	35.57	28348404
326 (in isoform 4)	Phosphorylation	-	35.57	-
332	Phosphorylation	GSEEEDDSHGEEGEP CCCCCCCCCCCCCCC	45.79	26657352
332 (in isoform 4)	Phosphorylation	-	45.79	-
333	Ubiquitination	SEEEDDSHGEEGEPS CCCCCCCCCCCCCCH	55.46	29967540
340	Phosphorylation	HGEEGEPSSIMNVPG CCCCCCCHHHCCCCC	28.35	18691976
340 (in isoform 4)	Phosphorylation	-	28.35	-
341	Phosphorylation	GEEGEPSSIMNVPGE CCCCCCHHHCCCCCC	36.25	23090842
349	Phosphorylation	IMNVPGESTLRREFL HCCCCCCHHHHHHHH	38.36	27251275
350	Phosphorylation	MNVPGESTLRREFLR CCCCCCHHHHHHHHH	21.71	27251275
363	Ubiquitination	LRLQQENKSNSEALK HHHHHHHHCHHHHHH	50.70	29967540
366	Phosphorylation	QQENKSNSEALKQQQ HHHHHCHHHHHHHHH	31.19	27470641
367	Ubiquitination	QENKSNSEALKQQQQ HHHHCHHHHHHHHHH	63.37	21963094
370	Ubiquitination	KSNSEALKQQQQLQQ HCHHHHHHHHHHHHH	53.78	21963094
388	Ubiquitination	RDPEAHIKHLLHQRQ HCHHHHHHHHHHHHH	20.52	29967540
422	Ubiquitination	EREQRKLQEKEQQRR HHHHHHHHHHHHHHH	63.85	29967540
435	Ubiquitination	RRLEDMQALRREEER HHHHHHHHHHHHHHH	9.08	29967540
462	Phosphorylation	QLEEQRQSERLQRQL HHHHHHHHHHHHHHH	27.20	27470641
475	Phosphorylation	QLQQEHAYLKSLQQQ HHHHHHHHHHHHHHH	19.30	-
477	Ubiquitination	QQEHAYLKSLQQQQQ HHHHHHHHHHHHHHH	36.12	29967540
478	Phosphorylation	QEHAYLKSLQQQQQQ HHHHHHHHHHHHHHH	28.90	29514088
490	Ubiquitination	QQQQQLQKQQQQQLL HHHHHHHHHHHHHCC	59.68	29967540
501	Methylation	QQLLPGDRKPLYHYG HHCCCCCCCCCCCCC	48.70	-
505	Phosphorylation	PGDRKPLYHYGRGMN CCCCCCCCCCCCCCC	11.09	21945579
507	Phosphorylation	DRKPLYHYGRGMNPA CCCCCCCCCCCCCCC	8.58	21945579
508	Phosphorylation	RKPLYHYGRGMNPAD CCCCCCCCCCCCCCC	13.32	32142685
509	Methylation	KPLYHYGRGMNPADK CCCCCCCCCCCCCCC	33.74	24129315
535	Phosphorylation	RMNKQQNSPLAKSKP HHHHHCCCCCCCCCC	19.56	17192257
535 (in isoform 4)	Phosphorylation	-	19.56	-
540	Phosphorylation	QNSPLAKSKPGSTGP CCCCCCCCCCCCCCC	38.18	23186163
544	Phosphorylation	LAKSKPGSTGPEPPI CCCCCCCCCCCCCCC	38.42	23186163
545	Phosphorylation	AKSKPGSTGPEPPIP CCCCCCCCCCCCCCC	63.77	27080861
555	Phosphorylation	EPPIPQASPGPPGPL CCCCCCCCCCCCCCC	25.74	26055452
563	Phosphorylation	PGPPGPLSQTPPMQR CCCCCCCCCCCCCCC	34.83	23401153
565	Phosphorylation	PPGPLSQTPPMQRPV CCCCCCCCCCCCCCC	26.45	23401153
581	Phosphorylation	PQEGPHKSLVAHRVP CCCCCCCCCEEECCC	25.66	23898821
590	Acetylation	VAHRVPLKPYAAPVP EEECCCCCCCCCCCC	29.88	26051181
590	Methylation	VAHRVPLKPYAAPVP EEECCCCCCCCCCCC	29.88	30590421
592	Phosphorylation	HRVPLKPYAAPVPRS ECCCCCCCCCCCCCC	17.51	28152594
599	Phosphorylation	YAAPVPRSQSLQDQP CCCCCCCCCCCCCCC	20.32	23927012
601	Phosphorylation	APVPRSQSLQDQPTR CCCCCCCCCCCCCCC	29.28	25159151
607	Phosphorylation	QSLQDQPTRNLAAFP CCCCCCCCCCCCCCC	26.93	23403867
621 (in isoform 4)	Phosphorylation	-	37.16	-
622	Phosphorylation	ASHDPDPAIPAPTAT CCCCCCCCCCCCCCC	27.98	32142685
624 (in isoform 4)	Phosphorylation	-	34.00	-
627	Phosphorylation	DPAIPAPTATPSARG CCCCCCCCCCCCCCC	45.32	29255136
629	Phosphorylation	AIPAPTATPSARGAV CCCCCCCCCCCCCCE	21.91	29255136
631	Phosphorylation	PAPTATPSARGAVIR CCCCCCCCCCCCEEE	26.66	29255136
641	Phosphorylation	GAVIRQNSDPTSEGP CCEEECCCCCCCCCC	36.31	23401153
644	Phosphorylation	IRQNSDPTSEGPGPS EECCCCCCCCCCCCC	44.38	25159151
645	Phosphorylation	RQNSDPTSEGPGPSP ECCCCCCCCCCCCCC	46.04	21955146
651	Phosphorylation	TSEGPGPSPNPPAWV CCCCCCCCCCCCCCC	43.13	28450419
657	Phosphorylation	PSPNPPAWVRPDNEA CCCCCCCCCCCCCCC	7.76	32142685
667 (in isoform 5)	Phosphorylation	-	66.54	24719451
671	Phosphorylation	APPKVPQRTSSIATA CCCCCCCCHHHHHHH	30.42	32142685
672	O-linked_Glycosylation	PPKVPQRTSSIATAL CCCCCCCHHHHHHHH	22.90	28657654
672	Phosphorylation	PPKVPQRTSSIATAL CCCCCCCHHHHHHHH	22.90	30183078
673	Phosphorylation	PKVPQRTSSIATALN CCCCCCHHHHHHHHC	23.18	30183078
674	Phosphorylation	KVPQRTSSIATALNT CCCCCHHHHHHHHCC	18.68	26055452
676 (in isoform 5)	Phosphorylation	-	6.70	-
677	Phosphorylation	QRTSSIATALNTSGA CCHHHHHHHHCCCCC	29.97	23090842
681	Phosphorylation	SIATALNTSGAGGSR HHHHHHCCCCCCCCC	29.41	28555341
681 (in isoform 4)	Phosphorylation	-	29.41	-
682	Phosphorylation	IATALNTSGAGGSRP HHHHHCCCCCCCCCC	26.10	28985074
683 (in isoform 5)	Phosphorylation	-	26.63	24719451
687	Phosphorylation	NTSGAGGSRPAQAVR CCCCCCCCCCHHHHH	33.89	23090842
687 (in isoform 2)	Phosphorylation	-	33.89	24719451
687 (in isoform 3)	Phosphorylation	-	33.89	24719451
696 (in isoform 2)	Phosphorylation	-	19.32	-
696 (in isoform 3)	Phosphorylation	-	19.32	-
699	Phosphorylation	AVRARPRSNSAWQIY HHHCCCCCCCHHHHH	37.51	21945579
701	Phosphorylation	RARPRSNSAWQIYLQ HCCCCCCCHHHHHHH	31.93	22167270
703 (in isoform 2)	Phosphorylation	-	5.73	24719451
703 (in isoform 3)	Phosphorylation	-	5.73	24719451
706	Phosphorylation	SNSAWQIYLQRRAER CCCHHHHHHHHHHHC	5.02	21945579
712	Phosphorylation	IYLQRRAERGTPKPP HHHHHHHHCCCCCCC	50.24	32142685
713	Phosphorylation	YLQRRAERGTPKPPG HHHHHHHCCCCCCCC	53.99	33259812
715	Phosphorylation	QRRAERGTPKPPGPP HHHHHCCCCCCCCCC	34.07	23927012
726	Phosphorylation	PGPPAQPPGPPNASS CCCCCCCCCCCCCCC	56.71	32142685
732	Phosphorylation	PPGPPNASSNPDLRR CCCCCCCCCCCCCCC	36.97	23401153
733	Phosphorylation	PGPPNASSNPDLRRS CCCCCCCCCCCCCCC	50.39	23927012
740	Phosphorylation	SNPDLRRSDPGWERS CCCCCCCCCCCCCCC	41.54	18691976
743	Phosphorylation	DLRRSDPGWERSDSV CCCCCCCCCCCCCCC	43.82	32142685
743 (in isoform 4)	Phosphorylation	-	43.82	-
747	Phosphorylation	SDPGWERSDSVLPAS CCCCCCCCCCCCCCC	23.79	23927012
749	Phosphorylation	PGWERSDSVLPASHG CCCCCCCCCCCCCCC	27.14	23927012
752 (in isoform 4)	Phosphorylation	-	29.57	-
754	Phosphorylation	SDSVLPASHGHLPQA CCCCCCCCCCCCCCC	28.23	23401153
757 (in isoform 3)	Phosphorylation	-	28.98	25278378
757 (in isoform 4)	Phosphorylation	-	28.98	-
758 (in isoform 4)	Phosphorylation	-	3.88	-
762 (in isoform 4)	Phosphorylation	-	27.76	-
763	Phosphorylation	GHLPQAGSLERNRVG CCCCCCCCCCCCCCC	30.03	29255136
764 (in isoform 3)	Phosphorylation	-	7.58	25278378
765 (in isoform 3)	Phosphorylation	-	50.00	25278378
772	Phosphorylation	ERNRVGVSSKPDSSP CCCCCCCCCCCCCCC	27.07	23927012
773	Phosphorylation	RNRVGVSSKPDSSPV CCCCCCCCCCCCCCC	45.89	23927012
777	Phosphorylation	GVSSKPDSSPVLSPG CCCCCCCCCCCCCCC	45.10	25159151
778	Phosphorylation	VSSKPDSSPVLSPGN CCCCCCCCCCCCCCC	26.80	23927012
782	Phosphorylation	PDSSPVLSPGNKAKP CCCCCCCCCCCCCCC	30.87	25159151
809	Phosphorylation	FVLLKERTLDEAPRP EEEEEECCCCCCCCC	39.39	26657352
826	Phosphorylation	KAMDYSSSSEEVESS CCCCCCCCCCCCCCC	35.51	32142685
833	Phosphorylation	SSEEVESSEDDEEEG CCCCCCCCCCCCCCC	31.38	24076635
839	Ubiquitination	SSEDDEEEGEGGPAE CCCCCCCCCCCCCCC	61.57	33845483
851	Phosphorylation	PAEGSRDTPGGRSDG CCCCCCCCCCCCCCC	23.79	23898821
852	Ubiquitination	AEGSRDTPGGRSDGD CCCCCCCCCCCCCCC	47.75	27667366
856	Phosphorylation	RDTPGGRSDGDTDSV CCCCCCCCCCCCCCE	49.58	28348404
860	Phosphorylation	GGRSDGDTDSVSTMV CCCCCCCCCCEEEEE	35.39	28348404
862	Phosphorylation	RSDGDTDSVSTMVVH CCCCCCCCEEEEEEE	21.76	28787133
864	Phosphorylation	DGDTDSVSTMVVHDV CCCCCCEEEEEEEEH	18.10	28348404
865	Phosphorylation	GDTDSVSTMVVHDVE CCCCCEEEEEEEEHH	16.30	28348404
881	Phosphorylation	ITGTQPPYGGGTMVV HCCCCCCCCCCCEEE	34.78	32142685
886 (in isoform 4)	Phosphorylation	-	2.92	-
889	Phosphorylation	GGGTMVVQRTPEEER CCCCEEEECCHHHHH	31.92	32142685
891	Phosphorylation	GTMVVQRTPEEERNL CCEEEECCHHHHHCC	20.26	-
894	Ubiquitination	VVQRTPEEERNLLHA EEECCHHHHHCCCCC	64.56	33845483
896 (in isoform 4)	Phosphorylation	-	42.23	-
898	Phosphorylation	TPEEERNLLHADSNG CHHHHHCCCCCCCCC	4.67	32142685
898 (in isoform 4)	Phosphorylation	-	4.67	-
902	Ubiquitination	ERNLLHADSNGYTNL HHCCCCCCCCCCCCC	31.71	33845483
903	Phosphorylation	RNLLHADSNGYTNLP HCCCCCCCCCCCCCC	32.70	26356563
906	Phosphorylation	LHADSNGYTNLPDVV CCCCCCCCCCCCCCC	9.19	25159151
907	Phosphorylation	HADSNGYTNLPDVVQ CCCCCCCCCCCCCCC	31.51	25159151
907	Ubiquitination	HADSNGYTNLPDVVQ CCCCCCCCCCCCCCC	31.51	27667366
911	Ubiquitination	NGYTNLPDVVQPSHS CCCCCCCCCCCCCCC	57.28	33845483
915	Ubiquitination	NLPDVVQPSHSPTEN CCCCCCCCCCCCCCC	23.54	27667366
916	Phosphorylation	LPDVVQPSHSPTENS CCCCCCCCCCCCCCC	21.36	23927012
918	Phosphorylation	DVVQPSHSPTENSKG CCCCCCCCCCCCCCC	37.54	25159151
918	Ubiquitination	DVVQPSHSPTENSKG CCCCCCCCCCCCCCC	37.54	27667366
920	Phosphorylation	VQPSHSPTENSKGQS CCCCCCCCCCCCCCC	51.30	23927012
923	Phosphorylation	SHSPTENSKGQSPPS CCCCCCCCCCCCCCC	31.75	23927012
924	Ubiquitination	HSPTENSKGQSPPSK CCCCCCCCCCCCCCC	72.97	27667366
927	Phosphorylation	TENSKGQSPPSKDGS CCCCCCCCCCCCCCC	47.66	26055452
930	Phosphorylation	SKGQSPPSKDGSGDY CCCCCCCCCCCCCCC	46.92	29396449
931	Ubiquitination	KGQSPPSKDGSGDYQ CCCCCCCCCCCCCCC	72.40	33845483
935	Ubiquitination	PPSKDGSGDYQSRGL CCCCCCCCCCCCCCC	43.08	27667366
936	Ubiquitination	PSKDGSGDYQSRGLV CCCCCCCCCCCCCCE	39.74	27667366
937	Phosphorylation	SKDGSGDYQSRGLVK CCCCCCCCCCCCCEE	16.35	25394399
939	Phosphorylation	DGSGDYQSRGLVKAP CCCCCCCCCCCEECC	23.30	28152594
941	Ubiquitination	SGDYQSRGLVKAPGK CCCCCCCCCEECCCC	39.82	27667366
944	Ubiquitination	YQSRGLVKAPGKSSF CCCCCCEECCCCCCE	54.64	27667366
953	Ubiquitination	PGKSSFTMFVDLGIY CCCCCEEEEEEEEEE	2.65	27667366
960	Phosphorylation	MFVDLGIYQPGGSGD EEEEEEEECCCCCCC	13.57	-
970	Ubiquitination	GGSGDSIPITALVGG CCCCCCCCEEEEECC	23.10	27667366
972	Ubiquitination	SGDSIPITALVGGEG CCCCCCEEEEECCCC	14.48	27667366
973	Ubiquitination	GDSIPITALVGGEGT CCCCCEEEEECCCCC	10.85	27667366
986 (in isoform 4)	Phosphorylation	-	27.09	-
987	Phosphorylation	TRLDQLQYDVRKGSV CCHHHEEEEECCCCE	25.62	21945579
993	Phosphorylation	QYDVRKGSVVNVNPT EEEECCCCEEECCCC	26.40	28731282
1000	Phosphorylation	SVVNVNPTNTRAHSE CEEECCCCCCCCCCC	43.98	27486199
1002	Phosphorylation	VNVNPTNTRAHSETP EECCCCCCCCCCCCH	31.54	27486199
1006	Phosphorylation	PTNTRAHSETPEIRK CCCCCCCCCCHHHHH	42.03	18691976
1008	Phosphorylation	NTRAHSETPEIRKYK CCCCCCCCHHHHHHH	29.27	25159151
1052	Phosphorylation	RSGQGKVYGLIGRRR CCCCCCEEEEECCHH	15.08	24702127
1066 (in isoform 2)	Ubiquitination	-	3.63	21890473
1074 (in isoform 3)	Ubiquitination	-	14.73	21890473
1085	Phosphorylation	KRNKLRVYYLSWLRN CCCEEHHHHHHHHHH	7.70	25690035
1088	Phosphorylation	KLRVYYLSWLRNKIL EEHHHHHHHHHHHHH	14.14	23403867
1103	Ubiquitination	HNDPEVEKKQGWTTV CCCHHHHHHCCCEEE	56.42	-
1103 (in isoform 1)	Ubiquitination	-	56.42	21890473
1146	Ubiquitination	EVYAWAPKPYHKFMA EEEEECCCCCCCCCC	50.92	-
1150	Ubiquitination	WAPKPYHKFMAFKSF ECCCCCCCCCCHHHH	30.87	-
1199	Ubiquitination	VDSGNSYDIYIPVHI CCCCCEEEEEEEEEE	27.34	21890473
1205	Ubiquitination	YDIYIPVHIQSQITP EEEEEEEEECCCCCC	13.66	23000965
1236	Phosphorylation	CYEDEGVYVNTYGRI EEECCCEEEEECCHH	9.99	-
1249	Ubiquitination	RIIKDVVLQWGEMPT HHHHHHHHHCCCCCC	3.39	21890473
1254	Ubiquitination	VVLQWGEMPTSVAYI HHHHCCCCCCCHHHH	3.75	21890473
1254 (in isoform 2)	Ubiquitination	-	3.75	21890473
1255	Ubiquitination	VLQWGEMPTSVAYIC HHHCCCCCCCHHHHH	19.74	23000965
1260	Ubiquitination	EMPTSVAYICSNQIM CCCCCHHHHHCCCCC	10.58	23000965
1262	Ubiquitination	PTSVAYICSNQIMGW CCCHHHHHCCCCCCC	1.72	21890473
1262 (in isoform 3)	Ubiquitination	-	1.72	21890473
1265	Ubiquitination	VAYICSNQIMGWGEK HHHHHCCCCCCCCCC	15.68	21890473
1268	Ubiquitination	ICSNQIMGWGEKAIE HHCCCCCCCCCCEEE	30.76	23000965
1271	Ubiquitination	NQIMGWGEKAIEIRS CCCCCCCCCEEEEEE	32.57	21890473
1271	Ubiquitination	NQIMGWGEKAIEIRS CCCCCCCCCEEEEEE	32.57	21890473
1277	Ubiquitination	GEKAIEIRSVETGHL CCCEEEEEEECCCCC	23.12	23000965
1282	Ubiquitination	EIRSVETGHLDGVFM EEEEECCCCCCEEEH	13.07	21890473
1283	Ubiquitination	IRSVETGHLDGVFMH EEEECCCCCCEEEHH	28.32	21890473
1288	Ubiquitination	TGHLDGVFMHKRAQR CCCCCEEEHHHHHHH	5.33	21890473
1289	Ubiquitination	GHLDGVFMHKRAQRL CCCCEEEHHHHHHHH	3.19	23000965
1291	Ubiquitination	LDGVFMHKRAQRLKF CCEEEHHHHHHHHHH	37.33	23000965
1291 (in isoform 1)	Ubiquitination	-	37.33	21890473
1294	Ubiquitination	VFMHKRAQRLKFLCE EEHHHHHHHHHHHHH	56.10	23000965
1297	Ubiquitination	HKRAQRLKFLCERND HHHHHHHHHHHHCCC	38.18	23000965
1300	Ubiquitination	AQRLKFLCERNDKVF HHHHHHHHHCCCEEE	5.34	21890473
1305	Ubiquitination	FLCERNDKVFFASVR HHHHCCCEEEEEEEE	44.48	-
1306	Ubiquitination	LCERNDKVFFASVRS HHHCCCEEEEEEEEC	5.49	23000965
1310	Phosphorylation	NDKVFFASVRSGGSS CCEEEEEEEECCCCC	16.95	24961811
1317	Phosphorylation	SVRSGGSSQVYFMTL EEECCCCCEEEEEEE	27.26	-
1317	Ubiquitination	SVRSGGSSQVYFMTL EEECCCCCEEEEEEE	27.26	21890473
1319	Ubiquitination	RSGGSSQVYFMTLNR ECCCCCEEEEEEECC	4.26	21890473
1320	Phosphorylation	SGGSSQVYFMTLNRN CCCCCEEEEEEECCC	4.68	-
1320	Ubiquitination	SGGSSQVYFMTLNRN CCCCCEEEEEEECCC	4.68	21890473
1323	Phosphorylation	SSQVYFMTLNRNCIM CCEEEEEEECCCCCC	15.81	-
1323	Ubiquitination	SSQVYFMTLNRNCIM CCEEEEEEECCCCCC	15.81	23000965
1325	Ubiquitination	QVYFMTLNRNCIMNW EEEEEEECCCCCCCC	24.77	23000965
1326	Ubiquitination	VYFMTLNRNCIMNW- EEEEEECCCCCCCC-	42.37	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
280	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MINK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MINK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NCK1_HUMAN	NCK1	physical	15469942
M4K4_HUMAN	MAP4K4	physical	25852190

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MINK1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601; SER-641; SER-763;SER-777 AND SER-778, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-777; SER-778 ANDSER-782, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763; SER-777; SER-778AND SER-782, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-187; SER-535; SER-601;SER-641; SER-763 AND SER-778, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, AND MASSSPECTROMETRY.	15302935 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-706 AND TYR-906, ANDMASS SPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-906, AND MASSSPECTROMETRY.	17389395 [Abstract]