TPBG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPBG_HUMAN
• UniProt AC: Q13641
• Protein Name: Trophoblast glycoprotein
• Gene Name: TPBG
• Organism: Homo sapiens (Human).
• Sequence Length: 420
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization..
• Protein Sequence: MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	O-linked_Glycosylation	SSAPFLASAVSAQPP CCHHHHHHHHCCCCC	31.20	OGP
53	O-linked_Glycosylation	PFLASAVSAQPPLPD HHHHHHHCCCCCCCC	22.39	OGP
81	N-linked_Glycosylation	TVKCVNRNLTEVPTD HHHHCCCCCCCCCCC	46.22	UniProtKB CARBOHYD
99	Phosphorylation	YVRNLFLTGNQLAVL HHHHHHCCCCEEEEE	27.10	22817900
124	N-linked_Glycosylation	LAELAALNLSGSRLD HHHHHHHCCCCCCHH	27.68	19159218
143	Phosphorylation	GAFEHLPSLRQLDLS CHHHHCCCHHHCCCC	42.41	24719451
192	N-linked_Glycosylation	PPEDERQNRSFEGMV CCCHHHCCCCHHHHH	48.02	-
192	N-linked_Glycosylation	PPEDERQNRSFEGMV CCCHHHCCCCHHHHH	48.02	11903056
235	Phosphorylation	DVLAQLPSLRHLDLS HHHHCCCCCCCEECC	46.78	24719451
275	N-linked_Glycosylation	NALKVLHNGTLAELQ CCCHHHHCCHHHHHC	40.77	UniProtKB CARBOHYD
318	Ubiquitination	ETEVVQGKDRLTCAY HCCEECCCCCEEECC	23.68	29967540
403	Phosphorylation	MEGYHYRYEINADPR HCCCCEEEEECCCCC	17.62	27642862
415	Phosphorylation	DPRLTNLSSNSDV-- CCCCCCCCCCCCC--	29.55	23403867
416	Phosphorylation	PRLTNLSSNSDV--- CCCCCCCCCCCC---	43.44	22617229
418	Phosphorylation	LTNLSSNSDV----- CCCCCCCCCC-----	41.52	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPBG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPBG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPBG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIPC1_HUMAN	GIPC1	physical	11798178

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124, AND MASSSPECTROMETRY.
PubMed: 19159218