ZNF81_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF81_HUMAN
• UniProt AC: P51508
• Protein Name: Zinc finger protein 81
• Gene Name: ZNF81
• Organism: Homo sapiens (Human).
• Sequence Length: 661
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MPANEDAPQPGEHGSACEVSVSFEDVTVDFSREEWQQLDSTQRRLYQDVMLENYSHLLSVGFEVPKPEVIFKLEQGEGPWTLEGEAPHQSCSDGKFGIKPSQRRISGKSTFHSEMEGEDTRDDSLYSILEELWQDAEQIKRCQEKHNKLLSRTTFLNKKILNTEWDYEYKDFGKFVHPSPNLILSQKRPHKRDSFGKSFKHNLDLHIHNKSNAAKNLDKTIGHGQVFTQNSSYSHHENTHTGVKFCERNQCGKVLSLKHSLSQNVKFPIGEKANTCTEFGKIFTQRSHFFAPQKIHTVEKPHELSKCVNVFTQKPLLSIYLRVHRDEKLYICTKCGKAFIQNSELIMHEKTHTREKPYKCNECGKSFFQVSSLLRHQTTHTGEKLFECSECGKGFSLNSALNIHQKIHTGERHHKCSECGKAFTQKSTLRMHQRIHTGERSYICTQCGQAFIQKAHLIAHQRIHTGEKPYECSDCGKSFPSKSQLQMHKRIHTGEKPYICTECGKAFTNRSNLNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKPYVCADCGRAFIQKSELITHQRIHTTEKPYKCPDCEKSFSKKPHLKVHQRIHTGEKPYICAECGKAFTDRSNFNKHQTIHTGDKPYKCSDCGKGFTQKSVLSMHRNIHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	EEWQQLDSTQRRLYQ HHHHHCHHHHHHHHH	34.72	26074081
41	Phosphorylation	EWQQLDSTQRRLYQD HHHHCHHHHHHHHHH	26.26	26074081
46	Phosphorylation	DSTQRRLYQDVMLEN HHHHHHHHHHHHHHC	10.80	26074081
54	Phosphorylation	QDVMLENYSHLLSVG HHHHHHCHHHHHHCC	6.52	-
106	Phosphorylation	KPSQRRISGKSTFHS CHHHCCCCCCCCCCC	38.05	-
124	Phosphorylation	GEDTRDDSLYSILEE CCCCCCHHHHHHHHH	33.23	-
127	Phosphorylation	TRDDSLYSILEELWQ CCCHHHHHHHHHHHH	26.45	-
179	Phosphorylation	FGKFVHPSPNLILSQ HHHCCCCCCCCEECC	16.13	24043423
220	Phosphorylation	AAKNLDKTIGHGQVF HHHHCCCCCCCCCEE	31.68	24719451
241	Phosphorylation	SHHENTHTGVKFCER CCCCCCCCCEEEECC	41.45	24719451
256	Phosphorylation	NQCGKVLSLKHSLSQ CCCCCEEECCCCCCC	38.06	24719451
258	Methylation	CGKVLSLKHSLSQNV CCCEEECCCCCCCCC	27.98	115978107
266	Sumoylation	HSLSQNVKFPIGEKA CCCCCCCCCCCCCCC	53.63	28112733
266	Ubiquitination	HSLSQNVKFPIGEKA CCCCCCCCCCCCCCC	53.63	29967540
318	Phosphorylation	FTQKPLLSIYLRVHR HHCCCCEEEEEEECC	19.50	29496907
333	Phosphorylation	DEKLYICTKCGKAFI CCCEEEECCCCCCHH	21.58	24719451
343	Phosphorylation	GKAFIQNSELIMHEK CCCHHHCCCEEEECC	19.87	24719451
351	Phosphorylation	ELIMHEKTHTREKPY CEEEECCCCCCCCCC	26.04	29083192
353	Phosphorylation	IMHEKTHTREKPYKC EEECCCCCCCCCCCC	45.84	29083192
359	Sumoylation	HTREKPYKCNECGKS CCCCCCCCCCCCCCC	38.83	-
359	Sumoylation	HTREKPYKCNECGKS CCCCCCCCCCCCCCC	38.83	-
372	Phosphorylation	KSFFQVSSLLRHQTT CCHHHHHHHHHCCCC	32.35	24719451
396	Phosphorylation	SECGKGFSLNSALNI CCCCCCCCHHHHHHH	35.00	-
465	Phosphorylation	IAHQRIHTGEKPYEC HHCCCCCCCCCCEEC	44.67	27282143
468	Ubiquitination	QRIHTGEKPYECSDC CCCCCCCCCEECCCC	55.00	-
493	Phosphorylation	QMHKRIHTGEKPYIC HHHCCCCCCCCCEEE	44.67	20736484
496	Sumoylation	KRIHTGEKPYICTEC CCCCCCCCCEEECCC	44.45	-
496	Sumoylation	KRIHTGEKPYICTEC CCCCCCCCCEEECCC	44.45	-
498	Phosphorylation	IHTGEKPYICTECGK CCCCCCCEEECCCHH	21.50	-
549	Phosphorylation	NKHQTIHTGEKPYVC CCCCEEECCCCCEEE	43.09	-
590	Phosphorylation	KCPDCEKSFSKKPHL CCCCCHHHCCCCCCC	16.68	24719451
605	Phosphorylation	KVHQRIHTGEKPYIC EEEEECCCCCCCEEE	44.67	28111955
608	Sumoylation	QRIHTGEKPYICAEC EECCCCCCCEEEECC	44.45	-
608	Sumoylation	QRIHTGEKPYICAEC EECCCCCCCEEEECC	44.45	-
633	Phosphorylation	NKHQTIHTGDKPYKC CCCCEEECCCCCEEC	43.13	24719451
639	Acetylation	HTGDKPYKCSDCGKG ECCCCCEECCCCCCC	35.47	7678545
650	Acetylation	CGKGFTQKSVLSMHR CCCCCCHHHHHHHCC	39.20	7678553

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF81_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF81_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF81_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZNF81_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300498: Mental retardation, X-linked 45 (MRX45)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.