HEMK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEMK1_HUMAN
• UniProt AC: Q9Y5R4
• Protein Name: HemK methyltransferase family member 1
• Gene Name: HEMK1
• Organism: Homo sapiens (Human).
• Sequence Length: 338
• Subcellular Localization: Mitochondrion .
• Protein Description: N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L..
• Protein Sequence: MELWGRMLWALLSGPGRRGSTRGWAFSSWQPQPPLAGLSSAIELVSHWTGVFEKRGIPEARESSEYIVAHVLGAKTFQSLRPALWTQPLTSQQLQCIRELSSRRLQRMPVQYILGEWDFQGLSLRMVPPVFIPRPETEELVEWVLEEVAQRSHAVGSPGSPLILEVGCGSGAISLSLLSQLPQSRVIAVDKREAAISLTHENAQRLRLQDRIWIIHLDMTSERSWTHLPWGPMDLIVSNPPYVFHQDMEQLAPEIRSYEDPAALDGGEEGMDIITHILALAPRLLKDSGSIFLEVDPRHPELVSSWLQSRPDLYLNLVAVRRDFCGRPRFLHIRRSGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	LGAKTFQSLRPALWT HCCCHHHHHCHHHHC	23.35	24719451
288	Phosphorylation	APRLLKDSGSIFLEV HHHHHHCCCCEEEEE	32.62	-
290	Phosphorylation	RLLKDSGSIFLEVDP HHHHCCCCEEEEECC	17.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEMK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEMK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEMK1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HEMK1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.