PDP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDP2_HUMAN
• UniProt AC: Q9P2J9
• Protein Name: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
• Gene Name: PDP2
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex..
• Protein Sequence: MSSTVSYWILNSTRNSIATLQGGRRLYSRYVSNRNKLKWRLFSRVPPTLNSSPCGGFTLCKAYRHTSTEEDDFHLQLSPEQINEVLRAGETTHKILDLESRVPNSVLRFESNQLAANSPVEDRRGVASCLQTNGLMFGIFDGHGGHACAQAVSERLFYYVAVSLMSHQTLEHMEGAMESMKPLLPILHWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREHPESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQFTPPHYYTPPYLTAEPEVTYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEADWHKTDLAQRPANLGLMQSLLLQRKASGLHEADQNAATRLIRHAIGNNEYGEMEAERLAAMLTLPEDLARMYRDDITVTVVYFNSESIGAYYKGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSTVSYWI ------CCCCCEEEH	34.41	23663014
3	Phosphorylation	-----MSSTVSYWIL -----CCCCCEEEHH	31.37	23663014
4	Phosphorylation	----MSSTVSYWILN ----CCCCCEEEHHH	13.23	23663014
6	Phosphorylation	--MSSTVSYWILNST --CCCCCEEEHHHCC	18.16	23663014
7	Phosphorylation	-MSSTVSYWILNSTR -CCCCCEEEHHHCCC	7.67	23663014
12	Phosphorylation	VSYWILNSTRNSIAT CEEEHHHCCCCEEEE	25.87	25404012
13	Phosphorylation	SYWILNSTRNSIATL EEEHHHCCCCEEEEH	32.56	29759185
28	Phosphorylation	QGGRRLYSRYVSNRN HCCHHHHHHHHCCCC	23.02	24719451
32	Phosphorylation	RLYSRYVSNRNKLKW HHHHHHHCCCCCCCE	22.57	30631047
43	Phosphorylation	KLKWRLFSRVPPTLN CCCEEECCCCCCCCC	36.64	-
58	Phosphorylation	SSPCGGFTLCKAYRH CCCCCCEEEEEEECC	34.22	-
66	Phosphorylation	LCKAYRHTSTEEDDF EEEEECCCCCCCCCC	28.48	26471730
67	Phosphorylation	CKAYRHTSTEEDDFH EEEECCCCCCCCCCE	27.91	25884760
68	Phosphorylation	KAYRHTSTEEDDFHL EEECCCCCCCCCCEE	44.54	26471730
94	Ubiquitination	RAGETTHKILDLESR HCCCCCHHHHCCHHC	42.76	-
357	Ubiquitination	DVQLKWSKELQRSIL CCCHHHCHHHHHHHH	62.42	-
438	Ubiquitination	LAEADWHKTDLAQRP HHHCCHHCCCHHHCC	39.21	21890473
459	Ubiquitination	QSLLLQRKASGLHEA HHHHHHHHHCCCCHH	33.66	20972266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AFG32_HUMAN	AFG3L2	physical	27880917
CLPX_HUMAN	CLPX	physical	27880917
UBR2_HUMAN	UBR2	physical	27880917
YMEL1_HUMAN	YME1L1	physical	27880917

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.