NR4A2_HUMAN - dbPTM
NR4A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NR4A2_HUMAN
UniProt AC P43354
Protein Name Nuclear receptor subfamily 4 group A member 2
Gene Name NR4A2
Organism Homo sapiens (Human).
Sequence Length 598
Subcellular Localization Cytoplasm. Nucleus. Mostly nuclear
oxidative stress promotes cytoplasmic localization.
Protein Description Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)..
Protein Sequence MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
71PhosphorylationMDNYSTGYDVKPPCL
HCCCCCCCCCCCCEE		20.04-
91SumoylationSGQQSSIKVEDIQMH
CCCCCEEEEEEEECC		41.33-
125PhosphorylationGSVYYKPSSPPTPTT
CCEEECCCCCCCCCC		51.8517890097
126PhosphorylationSVYYKPSSPPTPTTP
CEEECCCCCCCCCCC		43.3517681692
129PhosphorylationYKPSSPPTPTTPGFQ
ECCCCCCCCCCCCCE		36.3317681692
132PhosphorylationSSPPTPTTPGFQVQH
CCCCCCCCCCCEEEC		23.7117681692
174PhosphorylationKTPVSRLSLFSFKQS
CCCCCEEEEEEECCC		26.6822210691
177PhosphorylationVSRLSLFSFKQSPPG
CCEEEEEEECCCCCC		36.5129214152
181PhosphorylationSLFSFKQSPPGTPVS
EEEEECCCCCCCCCC		33.3829255136
185PhosphorylationFKQSPPGTPVSSCQM
ECCCCCCCCCCCCEE		26.7017681692
226UbiquitinationAVPNPIRKPASMGFP
ECCCCCCCCHHCCCC		45.73-
246PhosphorylationHASQLLDTQVPSPPS
CHHHHHCCCCCCCCC		31.2825002506
250PhosphorylationLLDTQVPSPPSRGSP
HHCCCCCCCCCCCCC		51.0625850435
253PhosphorylationTQVPSPPSRGSPSNE
CCCCCCCCCCCCCCC		53.2925002506
256PhosphorylationPSPPSRGSPSNEGLC
CCCCCCCCCCCCCCE		24.8425850435
258PhosphorylationPPSRGSPSNEGLCAV
CCCCCCCCCCCCEEC		49.5725850435
275PhosphorylationDNAACQHYGVRTCEG
CCCHHHHHCCCCCCC		7.46-
279PhosphorylationCQHYGVRTCEGCKGF
HHHHCCCCCCCCCCH		16.71-
296UbiquitinationRTVQKNAKYVCLANK
HHHHHCCCEEEECCC		47.84-
303UbiquitinationKYVCLANKNCPVDKR
CEEEECCCCCCCCHH		55.08-
335PhosphorylationMVKEVVRTDSLKGRR
CEEEEEECCCCCCCC		20.5228102081
337PhosphorylationKEVVRTDSLKGRRGR
EEEEECCCCCCCCCC		31.2228355574
347PhosphorylationGRRGRLPSKPKSPQE
CCCCCCCCCCCCCCC		67.2116223362
351PhosphorylationRLPSKPKSPQEPSPP
CCCCCCCCCCCCCCC		40.1023403867
356PhosphorylationPKSPQEPSPPSPPVS
CCCCCCCCCCCCCHH		49.0025850435
359PhosphorylationPQEPSPPSPPVSLIS
CCCCCCCCCCHHHHH		45.2629255136
363PhosphorylationSPPSPPVSLISALVR
CCCCCCHHHHHHHHH		26.2623403867
366PhosphorylationSPPVSLISALVRAHV
CCCHHHHHHHHHHHC		22.3523403867
375PhosphorylationLVRAHVDSNPAMTSL
HHHHHCCCCCCCCCC		43.5623663014
380PhosphorylationVDSNPAMTSLDYSRF
CCCCCCCCCCCHHHH		28.3923663014
381PhosphorylationDSNPAMTSLDYSRFQ
CCCCCCCCCCHHHHH		13.2223663014
384PhosphorylationPAMTSLDYSRFQANP
CCCCCCCHHHHHCCC		13.6723663014
385PhosphorylationAMTSLDYSRFQANPD
CCCCCCHHHHHCCCC		26.7023663014
530UbiquitinationRVEELQNKIVNCLKD
HHHHHHHHHHHHHHH		34.76-
558SumoylationYLSKLLGKLPELRTL
HHHHHHCCCHHHHHH		61.92-
558UbiquitinationYLSKLLGKLPELRTL
HHHHHHCCCHHHHHH		61.92-
558SumoylationYLSKLLGKLPELRTL
HHHHHHCCCHHHHHH		61.92-
577SumoylationLQRIFYLKLEDLVPP
HHHHHEEEHHHCCCC		38.1514559918
577SumoylationLQRIFYLKLEDLVPP
HHHHHEEEHHHCCCC		38.15-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
126SPhosphorylationKinaseMK01P28482
PhosphoELM
126SPhosphorylationKinaseMAPK1P63085
GPS
129TPhosphorylationKinaseMAPK1P63085
GPS
132TPhosphorylationKinaseMK01P28482
PhosphoELM
132TPhosphorylationKinaseMAPK1P63085
GPS
185TPhosphorylationKinaseMAPK1P63085
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NR4A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NR4A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SFPQ_HUMANSFPQphysical
19144721
NCOR2_HUMANNCOR2physical
19144721
SIN3A_HUMANSIN3Aphysical
19144721
SMCA4_HUMANSMARCA4physical
17043312
SMCA2_HUMANSMARCA2physical
17043312
RUNX1_HUMANRUNX1physical
21468021
RXRA_HUMANRXRAphysical
15604093
CSN5_HUMANCOPS5physical
15604093
RXRB_HUMANRXRBphysical
15604093
TCAL5_HUMANTCEAL5physical
20195357
BAZ1B_HUMANBAZ1Bphysical
20195357
RXRA_HUMANRXRAphysical
7705655
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NR4A2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181, AND MASSSPECTROMETRY.

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