dbPTM

NR1I3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NR1I3_HUMAN
UniProt AC	Q14994
Protein Name	Nuclear receptor subfamily 1 group I member 3
Gene Name	NR1I3
Organism	Homo sapiens (Human).
Sequence Length	352
Subcellular Localization	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Recruited to the cytoplasm by DNAJC7..
Protein Description	Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element..
Protein Sequence	MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
38	Phosphorylation	CKGFFRRTVSKSIGP CCHHHHHHCCCCCCC	25.52	8114692
192	Phosphorylation	LPIEDQISLLKGAAV CCHHHHHHHHHHHHH	23.24	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
38	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
38	T	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
38	T	Phosphorylation		19858220
Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NR1I3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FRIH_HUMAN	FTH1	physical	15604093
MAP4_HUMAN	MAP4	physical	15604093
PRS6B_HUMAN	PSMC4	physical	8603043
PRS8_HUMAN	PSMC5	physical	8603043
CHD9_HUMAN	CHD9	physical	16554032
SMD3_HUMAN	SNRPD3	physical	21988832
SNX13_HUMAN	SNX13	physical	21988832
RXRA_HUMAN	RXRA	physical	12130689
RXRA_HUMAN	RXRA	physical	19682433
RXRA_HUMAN	RXRA	physical	15888456
NCOA3_HUMAN	NCOA3	physical	15888456
NCOA2_HUMAN	NCOA2	physical	26186194
MED13_HUMAN	MED13	physical	26186194
MED12_HUMAN	MED12	physical	26186194
MED1_HUMAN	MED1	physical	26186194
UBB_HUMAN	UBB	physical	26186194
MED23_HUMAN	MED23	physical	26186194
MED24_HUMAN	MED24	physical	26186194
MED14_HUMAN	MED14	physical	26186194
PPM1B_HUMAN	PPM1B	physical	26186194
MED4_HUMAN	MED4	physical	26186194
NCOA1_HUMAN	NCOA1	physical	26186194
MED17_HUMAN	MED17	physical	26186194
MED15_HUMAN	MED15	physical	26186194
PRS8_HUMAN	PSMC5	physical	15604093
NCOA1_HUMAN	NCOA1	physical	15604093
PRGC1_HUMAN	PPARGC1A	physical	26407237
PML_HUMAN	PML	physical	26407237
SRC_HUMAN	SRC	physical	22896671
NR0B1_HUMAN	NR0B1	physical	22896671
NCOA1_HUMAN	NCOA1	physical	28514442
MED1_HUMAN	MED1	physical	28514442
MED4_HUMAN	MED4	physical	28514442
NCOA2_HUMAN	NCOA2	physical	28514442
MED14_HUMAN	MED14	physical	28514442
MED23_HUMAN	MED23	physical	28514442
PPM1B_HUMAN	PPM1B	physical	28514442
MED17_HUMAN	MED17	physical	28514442
MED13_HUMAN	MED13	physical	28514442
MED24_HUMAN	MED24	physical	28514442
UBB_HUMAN	UBB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NR1I3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Dephosphorylation of threonine 38 is required for nucleartranslocation and activation of human xenobiotic receptor CAR(NR1I3)."; Mutoh S., Osabe M., Inoue K., Moore R., Pedersen L., Perera L.,Rebolloso Y., Sueyoshi T., Negishi M.; J. Biol. Chem. 284:34785-34792(2009). Cited for: PHOSPHORYLATION AT THR-38, AND SUBCELLULAR LOCATION.	19858220 [Abstract]