NR0B1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR0B1_HUMAN
• UniProt AC: P51843
• Protein Name: Nuclear receptor subfamily 0 group B member 1
• Gene Name: NR0B1
• Organism: Homo sapiens (Human).
• Sequence Length: 470
• Subcellular Localization: Nucleus . Cytoplasm . Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus.
• Protein Description: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity)..
• Protein Sequence: MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	KDHPRQGSILYSMLT CCCCCCCHHHHHHHH	10.90	23663014
81	Phosphorylation	PRQGSILYSMLTSAK CCCCHHHHHHHHCCH	7.14	23663014
82	Phosphorylation	RQGSILYSMLTSAKQ CCCHHHHHHHHCCHH	12.13	23663014
85	Phosphorylation	SILYSMLTSAKQTYA HHHHHHHHCCHHCCC	20.28	23663014
86	Phosphorylation	ILYSMLTSAKQTYAA HHHHHHHCCHHCCCC	29.52	23663014
90	Phosphorylation	MLTSAKQTYAAPKAP HHHCCHHCCCCCCCC	17.89	30622161
91	Phosphorylation	LTSAKQTYAAPKAPE HHCCHHCCCCCCCCC	9.77	30622161
100	Phosphorylation	APKAPEATLGPCWGC CCCCCCCCCCCCCCC	30.50	-
108	Phosphorylation	LGPCWGCSCGSDPGV CCCCCCCCCCCCCCC	19.99	-
111	Phosphorylation	CWGCSCGSDPGVGRA CCCCCCCCCCCCCCC	44.98	-
147	Phosphorylation	PRQGSILYSLLTSSK CCCCHHHHHHHHCCC	8.80	25907765
148	Phosphorylation	RQGSILYSLLTSSKQ CCCHHHHHHHHCCCC	17.29	25907765
151	Phosphorylation	SILYSLLTSSKQTHV HHHHHHHHCCCCCCC	35.93	25907765
152	Phosphorylation	ILYSLLTSSKQTHVA HHHHHHHCCCCCCCC	35.19	25907765
153	Phosphorylation	LYSLLTSSKQTHVAP HHHHHHCCCCCCCCC	24.44	25907765
328	Phosphorylation	LTTRRRETGGNEPLP HHHHCHHCCCCCCCC	48.88	-
338	Phosphorylation	NEPLPVPTLQHHLAP CCCCCCCCCCCCCCC	39.01	-
354	Phosphorylation	AEARKVPSASQVQAI HHHCCCCCHHHHHHH	43.47	29083192
356	Phosphorylation	ARKVPSASQVQAIKC HCCCCCHHHHHHHHH	34.91	29083192
366	Phosphorylation	QAIKCFLSKCWSLNI HHHHHHHHHHHHCCC	12.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF31	Q96EP0	PMID:19237537

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR0B1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR0B1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRIP1_HUMAN	NRIP1	physical	11459805
STF1_HUMAN	NR5A1	physical	11459805
ANDR_HUMAN	AR	physical	12771131
PRGR_HUMAN	PGR	physical	12771131
PO5F1_HUMAN	POU5F1	physical	19528230
ERR1_HUMAN	ESRRA	physical	15604093
SNW1_HUMAN	SNW1	physical	15604093
PPARG_HUMAN	PPARG	physical	15604093
RNF31_HUMAN	RNF31	physical	19237537
ERR3_HUMAN	ESRRG	physical	25416956
STF1_HUMAN	NR5A1	physical	25416956
PPARG_HUMAN	PPARG	physical	22843091
PPARG_HUMAN	PPARG	physical	18381063

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.