dbPTM

ERR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ERR3_HUMAN
UniProt AC	P62508
Protein Name	Estrogen-related receptor gamma
Gene Name	ESRRG
Organism	Homo sapiens (Human).
Sequence Length	458
Subcellular Localization	Nucleus .
Protein Description	Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle..
Protein Sequence	MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	NKDRHIDSSCSSFIK CCCCCCCCCCHHCCC	32.42	-
34	Phosphorylation	KDRHIDSSCSSFIKT CCCCCCCCCHHCCCC	17.80	-
36	Phosphorylation	RHIDSSCSSFIKTEP CCCCCCCHHCCCCCC	30.17	-
37	Phosphorylation	HIDSSCSSFIKTEPS CCCCCCHHCCCCCCC	35.01	24719451
40	Sumoylation	SSCSSFIKTEPSSPA CCCHHCCCCCCCCCC	44.84	-
40	Sumoylation	SSCSSFIKTEPSSPA CCCHHCCCCCCCCCC	44.84	-
45	Phosphorylation	FIKTEPSSPASLTDS CCCCCCCCCCCCCCC	34.89	14702039
101	Phosphorylation	SGPVRKLYDDCSSTI CCCCHHHCCCCCCCC	16.87	29083192
105	Phosphorylation	RKLYDDCSSTIVEDP HHHCCCCCCCCCCCC	37.19	27732954
106	Phosphorylation	KLYDDCSSTIVEDPQ HHCCCCCCCCCCCCH	28.60	27251275
107	Phosphorylation	LYDDCSSTIVEDPQT HCCCCCCCCCCCCHH	16.85	27251275
112	Phosphorylation	SSTIVEDPQTKCEYM CCCCCCCCHHHHHHH	30.18	27251275
114	Phosphorylation	TIVEDPQTKCEYMLN CCCCCCHHHHHHHHH	42.95	29083192
118	Phosphorylation	DPQTKCEYMLNSMPK CCHHHHHHHHHHCCC	19.17	24275569
122	Phosphorylation	KCEYMLNSMPKRLCL HHHHHHHHCCCEEEE	32.28	29083192
136	Phosphorylation	LVCGDIASGYHYGVA EEECCCCCCCCCCHH	39.97	24275569
144	Phosphorylation	GYHYGVASCEACKAF CCCCCHHCHHHHHHH	15.30	24275569
195	Ubiquitination	CLKVGMLKEGVRLDR HHHHCCCCCCCCHHH	43.46	-
195	Acetylation	CLKVGMLKEGVRLDR HHHHCCCCCCCCHHH	43.46	12654505
219	Phosphorylation	RRIDAENSPYLNPQL HHCCCCCCCCCCHHH	13.36	28857561
221	Phosphorylation	IDAENSPYLNPQLVQ CCCCCCCCCCHHHCC	20.94	28857561
239	Phosphorylation	KPYNKIVSHLLVAEP CCCHHHHHHHHHCCH	16.34	22210691
256	Phosphorylation	IYAMPDPTVPDSDIK EEECCCCCCCHHHHH	52.64	22210691
260	Phosphorylation	PDPTVPDSDIKALTT CCCCCCHHHHHHHHH	34.85	22210691
356	Phosphorylation	ILQLVKKYKSMKLEK HHHHHHHHHCCCCCH	11.54	-
363	Ubiquitination	YKSMKLEKEEFVTLK HHCCCCCHHHHHHHH	73.34	-
377	Phosphorylation	KAIALANSDSMHIED HHHHHHCCCCCCCCH	26.00	21601212
420	Phosphorylation	RAGKMLMTLPLLRQT HHHHHHHHHHHHHHC	22.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ERR3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
40	K	Phosphorylation	16371476
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
40	K	Phosphorylation	16371476
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
40	K	Sumoylation	16371476
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
40	K	Sumoylation	16371476
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
45	S	Phosphorylation	19067653
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
45	S	Phosphorylation	19067653
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
45	S	Sumoylation	19067653
Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
45	S	Sumoylation	19067653
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ERR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERR3_HUMAN	ESRRG	physical	11864604
NCOA1_HUMAN	NCOA1	physical	11864604
ERR3_HUMAN	ESRRG	physical	12180985
ERR1_HUMAN	ESRRA	physical	17157980
NRIP1_HUMAN	NRIP1	physical	16439465
PRGC1_HUMAN	PPARGC1A	physical	15821111
NR0B2_HUMAN	NR0B2	physical	20516075
NR0B1_HUMAN	NR0B1	physical	15604093
DUT_HUMAN	DUT	physical	15604093
PROX1_HUMAN	PROX1	physical	15604093
NRIP1_HUMAN	NRIP1	physical	15604093
ERR1_HUMAN	ESRRA	physical	15604093
EBP_HUMAN	EBP	physical	15604093
PNRC1_HUMAN	PNRC1	physical	15604093
PNRC2_HUMAN	PNRC2	physical	15604093
ARHGF_HUMAN	ARHGEF15	physical	15604093
NR0B2_HUMAN	NR0B2	physical	21459093
TLE1_HUMAN	TLE1	physical	14651967
ERR3_HUMAN	ESRRG	physical	14651967
A4_HUMAN	APP	physical	21832049
PRGC1_HUMAN	PPARGC1A	physical	19171140
SRA1_HUMAN	SRA1	physical	20398657
ERR3_HUMAN	ESRRG	physical	25416956
KIFC3_HUMAN	KIFC3	physical	25416956
MEOX2_HUMAN	MEOX2	physical	25416956
NU160_HUMAN	NUP160	physical	25416956
SHOT1_HUMAN	KIAA1598	physical	25416956
DEUP1_HUMAN	CCDC67	physical	25416956
PRS8_HUMAN	PSMC5	physical	15604093
NCOA1_HUMAN	NCOA1	physical	15604093

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB02659	Cholic Acid
DB00255	Diethylstilbestrol

Regulatory Network of ERR3_HUMAN

Related Literatures of Post-Translational Modification

Sumoylation
Reference	PubMed
"Phosphorylation-dependent sumoylation regulates estrogen-relatedreceptor-alpha and -gamma transcriptional activity through a synergycontrol motif."; Tremblay A.M., Wilson B.J., Yang X.-J., Giguere V.; Mol. Endocrinol. 22:570-584(2008). Cited for: SUMOYLATION AT LYS-40, PHOSPHORYLATION AT SER-45, FUNCTION, ANDMUTAGENESIS OF LYS-40 AND SER-45.	18063693 [Abstract]
"Transcriptional ERRgamma2-mediated activation is regulated bysentrin-specific proteases."; Hentschke M., Suesens U., Borgmeyer U.; Biochem. J. 419:167-176(2009). Cited for: SUMOYLATION AT LYS-40, PHOSPHORYLATION AT SER-45, FUNCTION, ANDMUTAGENESIS OF PHE-38; ILE-39; LYS-40; THR-41; GLU-42; SER-44 ANDSER-45.	19067653 [Abstract]
"PDSM, a motif for phosphorylation-dependent SUMO modification."; Hietakangas V., Anckar J., Blomster H.A., Fujimoto M., Palvimo J.J.,Nakai A., Sistonen L.; Proc. Natl. Acad. Sci. U.S.A. 103:45-50(2006). Cited for: SUMOYLATION AT LYS-40, AND MUTAGENESIS OF LYS-40.	16371476 [Abstract]

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