ARHGF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARHGF_HUMAN
• UniProt AC: O94989
• Protein Name: Rho guanine nucleotide exchange factor 15
• Gene Name: ARHGEF15
• Organism: Homo sapiens (Human).
• Sequence Length: 841
• Subcellular Localization: Cell projection, dendrite. Expressed exclusively in dendrites of the developing hippocampus..
• Protein Description: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2..
• Protein Sequence: MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSAQSLPAATPP ---CCCCCCCCCCCC	35.72	24043423
10	Phosphorylation	AQSLPAATPPTQKPP CCCCCCCCCCCCCCC	31.72	24043423
13	Phosphorylation	LPAATPPTQKPPRII CCCCCCCCCCCCCCC	50.89	24043423
26	Phosphorylation	IIRPRPPSRSRAAQS CCCCCCCCCCCCCCC	45.64	23403867
33	Phosphorylation	SRSRAAQSPGPPHNG CCCCCCCCCCCCCCC	27.39	28857561
41	Phosphorylation	PGPPHNGSSPQELPR CCCCCCCCCCCCCCC	44.13	24719451
42	Phosphorylation	GPPHNGSSPQELPRN CCCCCCCCCCCCCCC	31.81	23403867
84	Phosphorylation	PPSASRASLDSQTSP CCCCCCCCCCCCCCC	31.44	21082442
93	Phosphorylation	DSQTSPDSPSSTPTP CCCCCCCCCCCCCCC	30.02	26657352
95	Phosphorylation	QTSPDSPSSTPTPSP CCCCCCCCCCCCCCC	51.28	27251275
107	Phosphorylation	PSPVSRRSASPEPAP CCCCCCCCCCCCCCC	31.80	26437602
109	Phosphorylation	PVSRRSASPEPAPRS CCCCCCCCCCCCCCC	30.92	26437602
231	Phosphorylation	RWVPVGGYEEVPRVP EEEECCCCCCCCCCC	11.73	-
242	Phosphorylation	PRVPRRASPLRTSRS CCCCCCCCCCCCCCC	23.74	24670416
246	Phosphorylation	RRASPLRTSRSRPHP CCCCCCCCCCCCCCC	35.85	29759185
247	Phosphorylation	RASPLRTSRSRPHPP CCCCCCCCCCCCCCC	23.09	26657352
353	Phosphorylation	PLQDEPLYQTYRAAV CCCCCCHHHHHHHHH	14.99	21029865
394	Phosphorylation	RPPGPRNTLWQELPA CCCCCCCCHHHHCHH	30.56	24719451
412	Phosphorylation	SGLLDTLSPQERRMQ HCHHHHCCHHHHHHH	26.99	24719451
421	Phosphorylation	QERRMQESLFEVVTS HHHHHHHHHHHHHHH	22.82	24719451
427	Phosphorylation	ESLFEVVTSEASYLR HHHHHHHHHHHHHHH	26.48	23911959
432	Phosphorylation	VVTSEASYLRSLRLL HHHHHHHHHHHHHHH	17.12	24719451
435	Phosphorylation	SEASYLRSLRLLTDT HHHHHHHHHHHHHHH	18.42	27174698
440	Phosphorylation	LRSLRLLTDTFVLSQ HHHHHHHHHHHHHHH	37.27	27174698
442	Phosphorylation	SLRLLTDTFVLSQAL HHHHHHHHHHHHHHH	15.48	27174698
446	Phosphorylation	LTDTFVLSQALRDTL HHHHHHHHHHHHHHC	14.22	27174698
454	Phosphorylation	QALRDTLTPRDHHTL HHHHHHCCCCCHHHH	20.54	24719451
516	Phosphorylation	DYVRNQQYQEETYSR HHHCCHHHCHHHHHH	14.23	24043423
520	Phosphorylation	NQQYQEETYSRLMDT CHHHCHHHHHHHHCC	26.50	24043423
521	Phosphorylation	QQYQEETYSRLMDTN HHHCHHHHHHHHCCC	8.62	24043423
522	Phosphorylation	QYQEETYSRLMDTNV HHCHHHHHHHHCCCH	26.76	24043423
527	Phosphorylation	TYSRLMDTNVRFSAE HHHHHHCCCHHHHHH	22.96	-
710	Phosphorylation	GPPTFRLSLLSNHQG CCCEEEEHHHHCCCC	24.02	23879269
713	Phosphorylation	TFRLSLLSNHQGRPT EEEEHHHHCCCCCCC	37.24	23879269
720	Phosphorylation	SNHQGRPTHRLLQAS HCCCCCCCHHHHHHH	20.47	23879269
727	Phosphorylation	THRLLQASSLSDMQR CHHHHHHHCHHHHHH	20.89	28857561
728	Phosphorylation	HRLLQASSLSDMQRW HHHHHHHCHHHHHHH	34.60	28857561
730	Phosphorylation	LLQASSLSDMQRWLG HHHHHCHHHHHHHHC	32.74	28270605
776	Phosphorylation	PAKTEGRSLESRAAP CCCCCCCCHHHCCCC	47.55	-
779	Phosphorylation	TEGRSLESRAAPKHL CCCCCHHHCCCCCHH	32.29	-
831	Phosphorylation	RLLEAVGSSSGTPNA HHHHHHCCCCCCCCC	18.09	26091039
832	Phosphorylation	LLEAVGSSSGTPNAP HHHHHCCCCCCCCCC	27.19	26091039
833	Phosphorylation	LEAVGSSSGTPNAPP HHHHCCCCCCCCCCC	48.67	26091039
835	Phosphorylation	AVGSSSGTPNAPPP- HHCCCCCCCCCCCC-	18.47	26091039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
353	Y	Phosphorylation	Kinase	EPHB2	P29323	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARHGF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARHGF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHOCN_HUMAN	MOB4	physical	16189514
CK049_HUMAN	C11orf49	physical	16189514
EPHA4_HUMAN	EPHA4	physical	12775584
CEP55_HUMAN	CEP55	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.