| UniProt ID | KIFC3_HUMAN | |
|---|---|---|
| UniProt AC | Q9BVG8 | |
| Protein Name | Kinesin-like protein KIFC3 | |
| Gene Name | KIFC3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 833 | |
| Subcellular Localization |
Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasmic vesicle membrane Peripheral membrane protein. Apical cell membrane. On membrane organelles immediately beneath the apical plasma memb |
|
| Protein Description | Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.. | |
| Protein Sequence | MVPSRRTWNLGATPSLRGLWRVGRAPEPEPGMARPAPAPASPAARPFPHTGPGRLRTGRGKDTPVCGDEDSSARSAARPALAQCRALSVDWAGPGSPHGLYLTLQVEHLKEKLISQAQEVSRLRSELGGTDLEKHRDLLMVENERLRQEMRRCEAELQELRTKPAGPCPGCEHSQESAQLRDKLSQLQLEMAESKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQEEERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQARNQHLQEQVAMQRQVLKEMEQQLQSSHQLTARLRAQIAMYESELERAHGQMLEEMQSLEEDKNRAIEEAFARAQVEMKAVHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIHLLHKGKPVSFELDKVFSPQASQQDVFQEVQALVTSCIDGFNVCIFAYGQTGAGKTYTMEGTAENPGINQRALQLLFSEVQEKASDWEYTITVSAAEIYNEVLRDLLGKEPQEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVGKSGAEGSRLREAQHINKSLSALGDVIAALRSRQGHVPFRNSKLTYLLQDSLSGDSKTLMVVQVSPVEKNTSETLYSLKFAERVRSVELGPGLRRAELGSWSSQEHLEWEPACQTPQPSARAHSAPSSGTSSRPGSIRRKLQPSGKSRPLPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MVPSRRTWNLG ----CCCCCCCCCCC | 24.00 | 28270605 | |
| 7 | Phosphorylation | -MVPSRRTWNLGATP -CCCCCCCCCCCCCC | 20.00 | 20860994 | |
| 13 | Phosphorylation | RTWNLGATPSLRGLW CCCCCCCCCCHHHHH | 16.18 | - | |
| 15 | Phosphorylation | WNLGATPSLRGLWRV CCCCCCCCHHHHHCC | 26.75 | 20860994 | |
| 41 | Phosphorylation | RPAPAPASPAARPFP CCCCCCCCCCCCCCC | 17.64 | 19691289 | |
| 45 | Methylation | APASPAARPFPHTGP CCCCCCCCCCCCCCC | 35.18 | 115481317 | |
| 50 | Phosphorylation | AARPFPHTGPGRLRT CCCCCCCCCCCCCCC | 45.36 | 27174698 | |
| 54 | Methylation | FPHTGPGRLRTGRGK CCCCCCCCCCCCCCC | 24.91 | 115481321 | |
| 75 | Phosphorylation | DEDSSARSAARPALA CCCCHHHHHHHHHHH | 26.46 | 28555341 | |
| 83 | Ubiquitination | AARPALAQCRALSVD HHHHHHHHHCEEECC | 20.34 | - | |
| 88 | Phosphorylation | LAQCRALSVDWAGPG HHHHCEEECCCCCCC | 19.62 | 22210691 | |
| 96 | Phosphorylation | VDWAGPGSPHGLYLT CCCCCCCCCCCEEEE | 19.50 | 25159151 | |
| 112 | Ubiquitination | QVEHLKEKLISQAQE EHHHHHHHHHHHHHH | 49.92 | - | |
| 115 | Phosphorylation | HLKEKLISQAQEVSR HHHHHHHHHHHHHHH | 29.87 | 20860994 | |
| 121 | Phosphorylation | ISQAQEVSRLRSELG HHHHHHHHHHHHHHC | 25.50 | 20860994 | |
| 134 | Ubiquitination | LGGTDLEKHRDLLMV HCCCCHHHHHHHHHH | 51.76 | - | |
| 163 | Ubiquitination | ELQELRTKPAGPCPG HHHHHHHCCCCCCCC | 26.83 | - | |
| 183 | Ubiquitination | ESAQLRDKLSQLQLE HHHHHHHHHHHHHHH | 43.53 | - | |
| 195 | Ubiquitination | QLEMAESKGMLSELN HHHHHHHCCHHHHHH | 39.58 | - | |
| 220 | Ubiquitination | AEVELRLKDCLAEKA HHHHHHHHHHHHHHH | 39.71 | - | |
| 226 | Ubiquitination | LKDCLAEKAQEEERL HHHHHHHHHHHHHHH | 50.16 | - | |
| 240 | Phosphorylation | LSRRLRDSHETIASL HHHHHHHHHHHHHHH | 19.45 | 28555341 | |
| 251 | Phosphorylation | IASLRAQSPPVKYVI HHHHHCCCCCEEEEE | 30.13 | 29396449 | |
| 259 | Ubiquitination | PPVKYVIKTVEVESS CCEEEEEEEEEECCH | 36.15 | - | |
| 269 | Ubiquitination | EVESSKTKQALSESQ EECCHHHHHHHCHHH | 36.99 | - | |
| 294 | Ubiquitination | AMQRQVLKEMEQQLQ HHHHHHHHHHHHHHH | 57.04 | - | |
| 317 | Phosphorylation | LRAQIAMYESELERA HHHHHHHHHHHHHHH | 13.79 | 22817900 | |
| 334 | Phosphorylation | QMLEEMQSLEEDKNR HHHHHHHHHHHHHHH | 36.12 | 20393185 | |
| 355 | Ubiquitination | ARAQVEMKAVHENLA HHHHHHHHHHHHHHH | 33.48 | - | |
| 377 | Phosphorylation | TLQPALRTLTNDYNG HHHHHHHHHHCCCCH | 38.49 | 20860994 | |
| 386 | Ubiquitination | TNDYNGLKRQVRGFP HCCCCHHHHHHCCHH | 42.03 | - | |
| 404 | Ubiquitination | QEALRSVKAEIGQAI HHHHHHHHHHHHHHH | 41.36 | - | |
| 408 | Ubiquitination | RSVKAEIGQAIEEVN HHHHHHHHHHHHHHH | 11.45 | - | |
| 434 | Ubiquitination | RELQLRKKCHNELVR HHHHHHHHHHHHHHH | 34.00 | - | |
| 443 | Acetylation | HNELVRLKGNIRVIA HHHHHHHCCCEEEEE | 39.07 | 19810313 | |
| 486 | Ubiquitination | IHLLHKGKPVSFELD HHHHCCCCCCEEEEC | 47.23 | - | |
| 508 | Ubiquitination | SQQDVFQEVQALVTS CCHHHHHHHHHHHHH | 25.73 | - | |
| 557 | Phosphorylation | RALQLLFSEVQEKAS HHHHHHHHHHHHHHC | 36.51 | 25159151 | |
| 593 | Ubiquitination | LGKEPQEKLEIRLCP HCCCCCCCCEEEECC | 46.29 | - | |
| 654 | Phosphorylation | SHALLIVTVRGVDCS CEEEEEEEECCCCCC | 9.48 | 20068231 | |
| 669 | Ubiquitination | TGLRTTGKLNLVDLA CCCCCCCCCCEEECC | 31.91 | - | |
| 758 | Phosphorylation | NTSETLYSLKFAERV CCCCCCHHHHHHHHH | 28.35 | 24719451 | |
| 781 | Phosphorylation | LRRAELGSWSSQEHL CCHHHCCCCCCCCCC | 36.09 | 23663014 | |
| 783 | Phosphorylation | RAELGSWSSQEHLEW HHHCCCCCCCCCCCC | 24.68 | 23927012 | |
| 784 | Phosphorylation | AELGSWSSQEHLEWE HHCCCCCCCCCCCCC | 33.07 | 23927012 | |
| 796 | Phosphorylation | EWEPACQTPQPSARA CCCCCCCCCCCCCCC | 24.63 | 20873877 | |
| 800 | Phosphorylation | ACQTPQPSARAHSAP CCCCCCCCCCCCCCC | 25.74 | 22210691 | |
| 805 | Phosphorylation | QPSARAHSAPSSGTS CCCCCCCCCCCCCCC | 40.67 | 20873877 | |
| 808 | Phosphorylation | ARAHSAPSSGTSSRP CCCCCCCCCCCCCCC | 40.91 | 27422710 | |
| 809 | Phosphorylation | RAHSAPSSGTSSRPG CCCCCCCCCCCCCCC | 45.06 | 30576142 | |
| 811 | Phosphorylation | HSAPSSGTSSRPGSI CCCCCCCCCCCCCCC | 26.02 | 30576142 | |
| 812 | Phosphorylation | SAPSSGTSSRPGSIR CCCCCCCCCCCCCCC | 28.07 | 20873877 | |
| 813 | Phosphorylation | APSSGTSSRPGSIRR CCCCCCCCCCCCCCC | 42.19 | 21712546 | |
| 817 | Phosphorylation | GTSSRPGSIRRKLQP CCCCCCCCCCCCCCC | 18.66 | 25159151 | |
| 828 | Phosphorylation | KLQPSGKSRPLPV-- CCCCCCCCCCCCC-- | 42.53 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KIFC3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KIFC3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KIFC3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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