| UniProt ID | RA51D_HUMAN | |
|---|---|---|
| UniProt AC | O75771 | |
| Protein Name | DNA repair protein RAD51 homolog 4 | |
| Gene Name | RAD51D | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 328 | |
| Subcellular Localization | Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere. | |
| Protein Description | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.. | |
| Protein Sequence | MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQFSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSATLQGDQT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Ubiquitination | LLRSHRIKTVVDLVS HHHHCCCCHHHHHHC | 34.91 | 29967540 | |
| 27 (in isoform 2) | Phosphorylation | - | 24.32 | 25278378 | |
| 33 (in isoform 2) | Phosphorylation | - | 24.30 | 25278378 | |
| 42 (in isoform 8) | Ubiquitination | - | 22.11 | - | |
| 42 | Ubiquitination | DLEEVAQKCGLSYKA CHHHHHHHCCCCHHH | 22.11 | 29967540 | |
| 46 (in isoform 2) | Phosphorylation | - | 15.18 | 25278378 | |
| 47 (in isoform 2) | Phosphorylation | - | 12.81 | 25278378 | |
| 49 (in isoform 2) | Phosphorylation | - | 10.07 | 25278378 | |
| 77 | Phosphorylation | DLYEELKTSTAILST HHHHHHHHHHHHHHC | 43.89 | - | |
| 77 (in isoform 6) | Phosphorylation | - | 43.89 | 20562096 | |
| 77 (in isoform 5) | Phosphorylation | - | 43.89 | 26471730 | |
| 78 | Phosphorylation | LYEELKTSTAILSTG HHHHHHHHHHHHHCC | 17.79 | - | |
| 78 (in isoform 6) | Phosphorylation | - | 17.79 | 20562096 | |
| 78 (in isoform 5) | Phosphorylation | - | 17.79 | 26471730 | |
| 79 (in isoform 6) | Phosphorylation | - | 23.97 | 26471730 | |
| 79 (in isoform 5) | Phosphorylation | - | 23.97 | 26471730 | |
| 98 | Phosphorylation | KLLDAGLYTGEVTEI HHHHCCCCCCEEEEE | 16.28 | 21712546 | |
| 99 | Phosphorylation | LLDAGLYTGEVTEIV HHHCCCCCCEEEEEE | 31.73 | 21712546 | |
| 102 (in isoform 6) | Phosphorylation | - | 6.52 | 20562096 | |
| 213 | Phosphorylation | DSVTAVVSPLLGGQQ ECCEEEEEHHCCCCH | 11.84 | - | |
| 236 | Phosphorylation | QLARELKTLARDLGM HHHHHHHHHHHHHCC | 37.97 | 24719451 | |
| 248 | Phosphorylation | LGMAVVVTNHITRDR HCCEEEEECCCCCCC | 14.96 | 24719451 | |
| 261 | Acetylation | DRDSGRLKPALGRSW CCCCCCCCCCCCCCC | 27.21 | 23749302 | |
| 261 | Ubiquitination | DRDSGRLKPALGRSW CCCCCCCCCCCCCCC | 27.21 | - | |
| 280 | Phosphorylation | STRILLDTIEGAGAS CCCEEHHHCCCCCCC | 22.39 | 22210691 | |
| 281 (in isoform 8) | Ubiquitination | - | 4.61 | - | |
| 287 | Phosphorylation | TIEGAGASGGRRMAC HCCCCCCCCHHHHHH | 40.64 | 25072903 | |
| 297 | Ubiquitination | RRMACLAKSSRQPTG HHHHHHHCCCCCCCC | 35.70 | - | |
| 317 (in isoform 8) | Ubiquitination | - | 29.69 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RA51D_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RA51D_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RA51D_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RADIL_HUMAN | RADIL | physical | 17353931 | |
| DCD_HUMAN | DCD | physical | 17353931 | |
| BLM_HUMAN | BLM | physical | 12975363 | |
| XRCC2_HUMAN | XRCC2 | physical | 12975363 | |
| XRCC2_HUMAN | XRCC2 | physical | 15115758 | |
| XRCC2_HUMAN | XRCC2 | physical | 11842113 | |
| SWAP1_HUMAN | SWSAP1 | physical | 21965664 | |
| XRCC2_HUMAN | XRCC2 | physical | 25416956 | |
| IKZF1_HUMAN | IKZF1 | physical | 25416956 | |
| IKZF3_HUMAN | IKZF3 | physical | 25416956 | |
| AMOL2_HUMAN | AMOTL2 | physical | 25416956 | |
| PRD14_HUMAN | PRDM14 | physical | 25416956 | |
| LZTS2_HUMAN | LZTS2 | physical | 25416956 | |
| LNX1_HUMAN | LNX1 | physical | 25416956 | |
| CA094_HUMAN | C1orf94 | physical | 25416956 | |
| CE57L_HUMAN | CEP57L1 | physical | 25416956 | |
| RN138_HUMAN | RNF138 | physical | 27161866 | |
| RA51C_HUMAN | RAD51C | physical | 27161866 | |
| XRCC2_HUMAN | XRCC2 | physical | 27161866 | |
| RN138_HUMAN | RNF138 | physical | 27195665 | |
| ICMT_HUMAN | ICMT | physical | 28514442 | |
| WDR19_HUMAN | WDR19 | physical | 28514442 | |
| FANCJ_HUMAN | BRIP1 | physical | 28514442 | |
| MKS1_HUMAN | MKS1 | physical | 28514442 | |
| FANCA_HUMAN | FANCA | physical | 28215707 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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