SCEL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCEL_HUMAN
• UniProt AC: O95171
• Protein Name: Sciellin
• Gene Name: SCEL
• Organism: Homo sapiens (Human).
• Sequence Length: 688
• Subcellular Localization: Cytoplasm. Membrane. May become cross-linked to membrane proteins by transglutaminase.
• Protein Description: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope..
• Protein Sequence: MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	NVTLRKMSPTGNEMK CCEEEECCCCCCCCC	23.50	25394399
12	Phosphorylation	TLRKMSPTGNEMKST EEEECCCCCCCCCCC	45.38	22617229
18	Phosphorylation	PTGNEMKSTTQGTTR CCCCCCCCCCCCCCH	35.06	-
38	Phosphorylation	HEVNKRRTFLQDNSW HHHHHHHHHHCCCCH	32.50	26074081
44	Phosphorylation	RTFLQDNSWIKKRPE HHHHCCCCHHHCCCH	38.17	26074081
58	Phosphorylation	EEEKDENYGRVVLNR HHHCCCCCCEEEECC	12.31	25394399
68	Phosphorylation	VVLNRHNSHDALDRK EEECCCCCCHHHHHC	19.33	28355574
83	Acetylation	VNERDVPKATISRYS CCCCCCCHHHHCCCC	58.99	-
85	Phosphorylation	ERDVPKATISRYSSD CCCCCHHHHCCCCCC	26.13	23663014
87	Phosphorylation	DVPKATISRYSSDDT CCCHHHHCCCCCCCH	22.32	23663014
89	Phosphorylation	PKATISRYSSDDTLD CHHHHCCCCCCCHHH	13.02	23663014
90	Phosphorylation	KATISRYSSDDTLDR HHHHCCCCCCCHHHH	26.61	22617229
91	Phosphorylation	ATISRYSSDDTLDRI HHHCCCCCCCHHHHH	30.48	28355574
94	Phosphorylation	SRYSSDDTLDRISDR CCCCCCCHHHHHHCC	35.23	23663014
99	Phosphorylation	DDTLDRISDRNDAAK CCHHHHHHCCCHHHH	31.26	30183078
108	Phosphorylation	RNDAAKTYKANTLDN CCHHHHHHHHCHHHH	13.85	20049867
109	Methylation	NDAAKTYKANTLDNQ CHHHHHHHHCHHHHH	40.15	-
112	Phosphorylation	AKTYKANTLDNQLTN HHHHHHCHHHHHHHH	40.11	27966365
121	Phosphorylation	DNQLTNRSMSMFRSL HHHHHHHHHHHHHHE	19.78	22617229
123	Phosphorylation	QLTNRSMSMFRSLEV HHHHHHHHHHHHEEE	18.93	23898821
127	Phosphorylation	RSMSMFRSLEVTKLQ HHHHHHHHEEEEEEC	20.02	22617229
143	Phosphorylation	GGSLNANTSNTIAST CCCCCCCCCCCCCCC	22.42	23090842
144	Phosphorylation	GSLNANTSNTIASTS CCCCCCCCCCCCCCC	31.61	23090842
149	Phosphorylation	NTSNTIASTSATTPV CCCCCCCCCCCCCCC	21.03	25404012
150	Phosphorylation	TSNTIASTSATTPVK CCCCCCCCCCCCCCC	17.23	27251275
151	Phosphorylation	SNTIASTSATTPVKK CCCCCCCCCCCCCCC	22.56	27251275
153	Phosphorylation	TIASTSATTPVKKKR CCCCCCCCCCCCCCC	31.25	23090842
154	Phosphorylation	IASTSATTPVKKKRQ CCCCCCCCCCCCCCC	26.29	25394399
162	Phosphorylation	PVKKKRQSWFPPPPP CCCCCCCCCCCCCCC	34.42	23898821
195	Phosphorylation	PPIPPKPSSPVSSPN CCCCCCCCCCCCCHH	54.09	30266825
196	Phosphorylation	PIPPKPSSPVSSPNQ CCCCCCCCCCCCHHH	37.54	30266825
199	Phosphorylation	PKPSSPVSSPNQLRQ CCCCCCCCCHHHHCC	43.38	30266825
200	Phosphorylation	KPSSPVSSPNQLRQD CCCCCCCCHHHHCCC	28.27	30266825
219	Phosphorylation	HPPKPGVYTETNRSA CCCCCCCCCCCCCHH	12.55	28152594
220	Phosphorylation	PPKPGVYTETNRSAE CCCCCCCCCCCCHHH	33.65	28152594
222	Phosphorylation	KPGVYTETNRSAERN CCCCCCCCCCHHHHH	28.29	28152594
225	Phosphorylation	VYTETNRSAERNIRS CCCCCCCHHHHHHHH	36.23	23898821
232	Phosphorylation	SAERNIRSQDLDNIV HHHHHHHHHCHHHHH	25.01	29460479
243 (in isoform 2)	Phosphorylation	-	32.72	25056879
263	Phosphorylation	NLIKMNKSLNRNQGL HHHHHHHHCCCCCCH	26.35	22617229
272	Phosphorylation	NRNQGLDSLFRANPK CCCCCHHHHHHHCHH	34.15	25404012
289	Phosphorylation	EREKRAKSLESLIYM HHHHHHHHHHHHHHH	36.06	28355574
292	Phosphorylation	KRAKSLESLIYMSTR HHHHHHHHHHHHHHC	25.92	30206219
295	Phosphorylation	KSLESLIYMSTRTDK HHHHHHHHHHHCCCC	7.12	22617229
297	Phosphorylation	LESLIYMSTRTDKDG HHHHHHHHHCCCCCC	9.58	30206219
298	Phosphorylation	ESLIYMSTRTDKDGK HHHHHHHHCCCCCCC	22.51	23312004
300	Phosphorylation	LIYMSTRTDKDGKGI HHHHHHCCCCCCCCH	47.71	-
309	Phosphorylation	KDGKGIQSLGSPIKV CCCCCHHHCCCCEEC	32.55	30266825
312	Phosphorylation	KGIQSLGSPIKVNQR CCHHHCCCCEECCCC	28.84	30266825
332	Phosphorylation	KGRQNLESVAKVNAR HHHHHHHHHHHHHHH	30.46	24719451
343	Phosphorylation	VNARMNKTSRRSEDL HHHHCCCCCCCCHHC	23.59	27966365
344	Phosphorylation	NARMNKTSRRSEDLD HHHCCCCCCCCHHCC	27.57	25394399
347	Phosphorylation	MNKTSRRSEDLDNAT CCCCCCCCHHCCCCC	34.06	22617229
354	Phosphorylation	SEDLDNATEVNPKGH CHHCCCCCCCCCCCC	46.88	23312004
385	Phosphorylation	PETNKNITRGQSLDN CCCCCCCCCCCCHHH	37.83	22617229
389	Phosphorylation	KNITRGQSLDNLIKV CCCCCCCCHHHHHHH	40.28	30266825
397	Phosphorylation	LDNLIKVTPEVKRSN HHHHHHHCHHHHHCC	14.55	30266825
417	Phosphorylation	LNNFIKVYPGTEKST HHHCEEECCCCCCCC	7.31	28152594
432	Phosphorylation	EGGQSLDSLIKVTPE CCCCCHHHHEECCCC	36.97	24719451
433	Phosphorylation	GGQSLDSLIKVTPER CCCCHHHHEECCCCC	4.36	33259812
437	Phosphorylation	LDSLIKVTPERNRTN HHHHEECCCCCCCCC	17.90	30266825
443	Phosphorylation	VTPERNRTNQGNQDL CCCCCCCCCCCCCCH	35.13	23898821
455	Phosphorylation	QDLENLIKVIPSANK CCHHHHHHHCCCCCC	36.96	33259812
463	Phosphorylation	VIPSANKSSEQGLDE HCCCCCCCCCCCHHH	38.63	23927012
464	Phosphorylation	IPSANKSSEQGLDEH CCCCCCCCCCCHHHH	35.23	23927012
475	Phosphorylation	LDEHINVSPKAVKNT HHHHCCCCHHHHHCC	19.05	30266825
490	Trimethylation	DGKQDLDKLIKVNPE CCCCCHHHHHHCCHH	60.45	-
490	Methylation	DGKQDLDKLIKVNPE CCCCCHHHHHHCCHH	60.45	24129315
524	Phosphorylation	AVIRNNQSQDLDNLI HHHCCCCCCCHHHHH	27.99	25056879
558	Phosphorylation	IEVNSHVSENKNGSS HHHHHHHCCCCCCCC	29.99	-
564	Phosphorylation	VSENKNGSSNTGAKQ HCCCCCCCCCCCCCC	29.79	-
567	Phosphorylation	NKNGSSNTGAKQAGP CCCCCCCCCCCCCCC	40.23	-
580	Phosphorylation	GPQDTVVYTRTYVEN CCCCEEEEEEEEECC	6.03	25394399
581	Phosphorylation	PQDTVVYTRTYVENS CCCEEEEEEEEECCC	12.62	28152594
583	Phosphorylation	DTVVYTRTYVENSKS CEEEEEEEEECCCCC	24.90	27794612
584	Phosphorylation	TVVYTRTYVENSKSP EEEEEEEEECCCCCC	11.50	27794612
588	Phosphorylation	TRTYVENSKSPKDGY EEEEECCCCCCCCCC	22.47	22617229
590	Phosphorylation	TYVENSKSPKDGYQE EEECCCCCCCCCCCC	36.68	22617229
595	Phosphorylation	SKSPKDGYQENISGK CCCCCCCCCCCCCCC	23.84	28152594
603	Phosphorylation	QENISGKYIQTVYST CCCCCCCEEEEEECC	11.20	28152594
608	Phosphorylation	GKYIQTVYSTSDRSV CCEEEEEECCCCCHH	15.04	25394399
609	Phosphorylation	KYIQTVYSTSDRSVI CEEEEEECCCCCHHH	19.66	28152594
623	Phosphorylation	IERDMCTYCRKPLGV HHHHHHHHCCCCCCC	5.82	-
665	Phosphorylation	ENLQAGDSIWIYRQT HHCCCCCEEEEEEEE	20.92	-
669	Phosphorylation	AGDSIWIYRQTIHCE CCCEEEEEEEEEECC	5.01	19060867
679	Phosphorylation	TIHCEPCYSKIMAKW EEECCCCHHHHHHHC	24.58	28152594
680	Phosphorylation	IHCEPCYSKIMAKWI EECCCCHHHHHHHCC	23.56	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCEL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCEL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCEL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TXNIP_HUMAN	TXNIP	physical	14632196
A4_HUMAN	APP	physical	21832049
NMI_HUMAN	NMI	physical	25416956
FXR2_HUMAN	FXR2	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
TSG10_HUMAN	TSGA10	physical	25416956
NMI_HUMAN	NMI	physical	21516116
RB11B_HUMAN	RAB11B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.